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Generic name: ixekizumab
Brand name: Taltz
Dosage form: subcutaneous injection
Drug class: Interleukin inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 4, 2023.

What is ixekizumab?

Ixekizumab is a biological medicine called a monoclonal antibody that is used to treat certain autoimmune disorders that cause inflammation.

Ixekizumab suppresses the immune system and helps to prevent inflammation. It works by binding to a protein in your body called cytokine interleukin 17A (IL-17A), preventing it from interacting with the IL-17 receptor. This blocks the release of substances called cytokine and chemokines that cause inflammation. 

Ixekizumab was approved by the US Food and Drug Administration (FDA) in 2016. No biosimilars of ixekizumab have been approved. Biosimilars are highly similar versions of ixekizumab that are designed to have the same effect on a person, but a biosimilar is not identical to the original version of the drug.

What is ixekizumab used for?

Ixekizumab is a prescription medicine used to treat:

It is not known if ixekizumab is safe and effective in children for conditions other than plaque psoriasis or in children under 6 years of age.

Important information

Ixekizumab is a medicine that affects your immune system. Ixekizumab may lower the ability of your immune system to fight infections and may increase your risk of infections, which can sometimes become serious.

Before starting ixekizumab, tell your healthcare provider if you:

After starting ixekizumab, call your healthcare provider right away if you have any of the symptoms of infection listed above.

Do not use ixekizumab if you have any symptoms of infection unless you are instructed to by your healthcare provider.

See “What are the side effects of ixekizumab?” below for more information about side effects.

Who should not use ixekizumab?

Do not use ixekizumab if you have had a severe allergic reaction to ixekizumab or any of the other ingredients in ixekizumab.

See below for a complete list of ingredients in ixekizumab.

What should I tell my doctor before using ixekizumab?

Before using ixekizumab, tell your healthcare provider about all of your medical conditions, including if you:

How should I use ixekizumab?

See the detailed “Instructions for Use” that comes with your ixekizumab for information on how to prepare and inject a dose of ixekizumab, and how to properly throw away (dispose of) used ixekizumab autoinjectors and prefilled syringes.

What happens if I miss a dose?

If you forget to take your dose:

Do not miss any doses of ixekizumab unless your healthcare provider says it is okay. If you forget to take your ixekizumab dose, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time.

What happens if I overdose?

If you inject more ixekizumab than prescribed, call your healthcare provider or go to the nearest emergency room right away.

Dosing information

The recommended dose of ixekizumab for different groups of patients are listed below.

What are the side effects of ixekizumab?

Ixekizumab may cause serious side effects, including:

The most common side effects of ixekizumab in adults and children include:

These are not all of the possible side effects of ixekizumab. Tell your healthcare provider about any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Pregnancy and breastfeeding

Tell your doctor if your are pregnant or plan to become pregnant. It is not known if ixekizumab can harm your unborn baby.

If you become pregnant while taking ixekizumab, you are encouraged to enroll in the pregnancy registry. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-800-284-1695 to enroll in the registry.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if ixekizumab passes into your breast milk.


Keep ixekizumab and all medicines out of the reach of children.

What are the ingredients in ixekizumab?

Active ingredient: ixekizumab

Inactive ingredients: Citric Acid Anhydrous, Polysorbate 80, Sodium Chloride, Sodium Citrate Dihydrate, and Water for Injection

Not made with natural rubber latex.

Ixekizumab is available under the brandname Taltz from Eli Lilly and Company Indianapolis, IN 46285, USA. Product of Ireland.

Popular FAQ

Treatment with Taltz (ixekizumab) starts to improve symptoms in patients with moderate-to-severe psoriasis within about 1-2 weeks, according to clinical trial results. After 12 weeks, nearly 90% of patients will have significantly clearer skin. Continue reading

Alcohol is not known to interact with Taltz (ixekizumab), a humanized interleukin-17A antagonist used to treat adults and children with moderate-to-severe plaque psoriasis and other conditions.

While Taltz may not interact with alcohol, the American Academy of Dermatology (AAD) and the National Psoriasis Foundation (NPF) recommend that dermatologists strongly advise patients with psoriasis to limit alcohol intake. It is thought that consumption of alcohol increases the risk for severe disease in patients with psoriasis. Continue reading

Weight gain is not a known side effect of Taltz (ixekizumab), a humanized interleukin-17A antagonist used to treat adults and children with moderate-to-severe plaque psoriasis, as well as other conditions.

While body weight can impact how well some drug treatments work, researchers have found that treatment with Taltz is safe and effective regardless of a patient's body weight. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.