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Ixekizumab Side Effects

For the Consumer

Applies to ixekizumab: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by ixekizumab. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking ixekizumab:

More common:
  • Body aches or pain
  • burning, dry, or itching eyes
  • cough or hoarseness
  • difficulty with breathing
  • discharge or excessive tearing
  • ear congestion
  • fever or chills
  • headache
  • itching in the genital or other skin areas
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • sore mouth or tongue
  • sore throat
  • unusual tiredness or weakness
  • white patches in the mouth or on the tongue
  • Hives or welts, Itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • rectal bleeding
  • redness of the skin
  • severe diarrhea
  • severe stomach pain

Minor Side Effects

Some of the side effects that can occur with ixekizumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Less common:
  • Nausea

For Healthcare Professionals

Applies to ixekizumab: subcutaneous solution


Common (1% to 10%): Urticaria
Uncommon (0.1% to 1%): Angioedema[Ref]


Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Oral candidiasis, inflammatory bowel disease[Ref]


Very common (10% or more): Neutropenia (11%)
Common (1% to 10%): Thrombocytopenia[Ref]


Very common (10% or more): Infections (26%), immunogenicity (22%)
Common (1% to 10%): Tinea infections, influenza
Uncommon (0.1% to 1%): Serious infections[Ref]


Very common (10% or more): Injection site reactions (17%), erythema, pain[Ref]


Common (1% to 10%): Conjunctivitis[Ref]


Very common (10% or more): Upper respiratory tract infections (including nasopharyngitis and rhinovirus infection) (14%)
Uncommon (0.1% to 1%): Rhinitis[Ref]


1. "Product Information. Taltz Autoinjector (ixekizumab)." Eli Lilly and Company, Indianapolis, IN.

Not all side effects for ixekizumab may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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