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Ixekizumab Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 6, 2022.

For the Consumer

Applies to ixekizumab: subcutaneous solution

Side effects requiring immediate medical attention

Along with its needed effects, ixekizumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ixekizumab:

More common

  • Body aches or pain
  • burning, dry, or itching eyes
  • chills
  • cough
  • difficulty with breathing
  • discharge or excessive tearing
  • ear congestion
  • fever
  • headache
  • hoarseness
  • itching in the genital or other skin areas
  • loss of voice
  • lower back or side pain
  • painful or difficult urination
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny or stuffy nose
  • scaling of the skin
  • sneezing
  • sore mouth or tongue
  • sore throat
  • unusual tiredness or weakness
  • white patches in the mouth or on the tongue

Less common

  • Chest tightness
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • general feeling of discomfort or illness
  • hives, itching, skin rash
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shivering
  • sweating
  • trouble sleeping
  • vomiting

Rare

  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • rectal bleeding
  • redness of the skin
  • severe diarrhea
  • severe stomach pain

Side effects not requiring immediate medical attention

Some side effects of ixekizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to ixekizumab: subcutaneous solution

Dermatologic

Common (1% to 10%): Urticaria

Uncommon (0.1% to 1%): Angioedema[Ref]

Gastrointestinal

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Oral candidiasis, inflammatory bowel disease[Ref]

Hematologic

Very common (10% or more): Neutropenia (11%)

Common (1% to 10%): Thrombocytopenia[Ref]

Immunologic

Very common (10% or more): Infections (26%), immunogenicity (22%)

Common (1% to 10%): Tinea infections, influenza

Uncommon (0.1% to 1%): Serious infections[Ref]

Local

Very common (10% or more): Injection site reactions (17%), erythema, pain[Ref]

Ocular

Common (1% to 10%): Conjunctivitis[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infections (including nasopharyngitis and rhinovirus infection) (14%)

Uncommon (0.1% to 1%): Rhinitis[Ref]

Hypersensitivity

Frequency not reported: Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria)[Ref]

Frequently asked questions

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Taltz Autoinjector (ixekizumab)." Eli Lilly and Company (2016):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer