Risankizumab Dosage

Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.

Applies to the following strengths: 150 mg/mL; rzaa 180 mg/1.2 mL; rzaa 360 mg/2.4 mL; 75 mg/0.83 mL; rzaa 60 mg/mL

Usual Adult Dose for Plaque Psoriasis

150 mg (two 75 mg injections) subcutaneously at Week 0, Week 4, and every 12 weeks thereafter

Comments:

Evaluate patients for tuberculosis (TB) infection prior to initiating this drug.

Use: For the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy

Data not available

Data not available

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Data not available

Administration advice:

This drug is intended for use under the guidance and supervision of a healthcare professional. Patients may self-inject after training in subcutaneous injection technique.
Visually inspect the prefilled syringe for particulate matter and discoloration prior to administration. It should be a colorless to slightly yellow and clear to slightly opalescent solution. It may contain a few translucent to white particles. Do not use if the solution contains large particles or is cloudy or discolored.
Inject 2 separate 75 mg single-dose prefilled syringes for the full 150 mg dose.
Discard prefilled syringes after use; do not reuse.
Administer the injections at different anatomic locations (e.g., thigh, abdomen) and not into areas where the skin is tender, bruised, erythematous, indurated, or affected by psoriasis. Administration into the upper outer arm may only be performed by a healthcare professional or caregiver.
If a dose is missed, administer it as soon as possible; thereafter, resume dosing at the regular scheduled time.
Instruct the patient that two separate 75 mg single-dose injections are required to achieve the 150 mg dose.
The "Instructions for Use" contains more detailed instructions on the preparation and administration of this drug.

Storage requirements:

Reconstitution/preparation techniques:

Before injecting remove the carton from the refrigerator and allow to reach room temperature out of direct sunlight (15 to 30 minutes) without removing the prefilled syringes from the carton.
Visually inspect the prefilled syringe for particulate matter and discoloration prior to administration. It should be a colorless to slightly yellow and clear to slightly opalescent solution. It may contain a few translucent to white particles. Do not use if the solution contains large particles or is cloudy or discolored.

General: