Secukinumab Dosage

Usual Adult Dose for Plaque Psoriasis

300 mg subcutaneously at weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks (each 300 mg dose is given as 2 subcutaneous injections of 150 mg); for some patients, a dosage of 150 mg subcutaneously may be acceptable

Use: Moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy

Usual Adult Dose for Psoriatic Arthritis

-With a loading dose: 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
-Without a loading dose: 150 mg subcutaneously every 4 weeks
-If the patient continues to have active psoriatic arthritis, consider increasing the dose to 300 mg subcutaneously every 4 weeks

Comments:
-For psoriatic arthritis patients with coexistent moderate to severe plaque psoriasis, use the dosage for plaque psoriasis.

Use: Active psoriatic arthritis

Usual Adult Dose for Ankylosing Spondylitis

-With a loading dose: 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
-Without a loading dose: 150 mg subcutaneously every 4 weeks

Use: Active ankylosing spondylitis

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Each injection should be administered at a different anatomic location (such as upper arms, thighs, or any quadrant of abdomen) than the previous injection, and not into areas where the skin is tender, bruised, erythematous, indurated, or affected by psoriasis.
-This drug is intended for use under the supervision of a physician. Patients may self-inject after proper training in subcutaneous injection technique using the Sensoready pen or prefilled syringe.
-The lyophilized powder for reconstitution is for healthcare provider use only.

Reconstitution/preparation techniques:
-Refer to the manufacturer product information.

Storage requirements:
-Refer to the manufacturer product information.

Patient advice:
-Read the patient leaflet thoroughly before use.
-The Sensoready Pens contain latex.
-The Sensoready Pens should not be shaken.