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Secukinumab Side Effects

For the Consumer

Applies to secukinumab: subcutaneous powder for solution, subcutaneous solution

As well as its needed effects, secukinumab may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking secukinumab, check with your doctor immediately:

More common:
  • Fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness
Less common:
  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • hives or welts, itching, or skin rash
  • loss of voice
  • redness of the skin
Incidence not known:
  • Diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rectal bleeding
  • severe diarrhea
  • severe stomach pain
  • tightness in the chest
  • weight loss

For Healthcare Professionals

Applies to secukinumab: subcutaneous powder for injection, subcutaneous solution

Dermatologic

Uncommon (0.1% to 1%): Tinea pedis, urticaria[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, oral herpes
Uncommon (0.1% to 1%): Oral candidiasis
Frequency not reported: Exacerbation of inflammatory bowel disease (IBD)[Ref]

Hypersensitivity

Rare (less than 0.1%): Anaphylaxis[Ref]

Immunologic

Uncommon (0.1% to 1%): Immunogenicity
Frequency not reported: Candida infections, herpes viral infections, staphylococcal skin infections, infections requiring treatment (increased as serum concentration of this drug is increased), neutropenia[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis (up to 12.3%)
Common (1% to 10%): Upper respiratory tract infection, rhinitis, pharyngitis, rhinorrhea[Ref]

Hematologic

Uncommon (0.1% to 1%): Neutropenia[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis[Ref]

Other

Uncommon (0.1% to 1%): Otitis externa[Ref]

References

1. "Product Information. Cosentyx (secukinumab)." Novartis Pharmaceuticals, East Hanover, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of secukinumab may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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