Secukinumab Side Effects

For the Consumer

Applies to secukinumab: subcutaneous powder for solution, subcutaneous solution

As well as its needed effects, secukinumab may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking secukinumab, check with your doctor immediately:

• Fever
• headache
• muscle aches
• sore throat
• stuffy or runny nose
• unusual tiredness or weakness

• Body aches or pain
• chills
• cough
• difficulty with breathing
• ear congestion
• hives or welts, itching, or skin rash
• loss of voice
• redness of the skin

• Diarrhea
• difficulty with swallowing
• dizziness
• fast heartbeat
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rectal bleeding
• severe diarrhea
• severe stomach pain
• tightness in the chest
• weight loss

For Healthcare Professionals

Applies to secukinumab: subcutaneous powder for injection, subcutaneous solution

Dermatologic

Uncommon (0.1% to 1%): Tinea pedis, urticaria^[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, oral herpes
Uncommon (0.1% to 1%): Oral candidiasis
Frequency not reported: Exacerbation of inflammatory bowel disease (IBD)^[Ref]

Hypersensitivity

Rare (less than 0.1%): Anaphylaxis^[Ref]

Immunologic

Uncommon (0.1% to 1%): Immunogenicity
Frequency not reported: Candida infections, herpes viral infections, staphylococcal skin infections, infections requiring treatment (increased as serum concentration of this drug is increased), neutropenia^[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis (up to 12.3%)
Common (1% to 10%): Upper respiratory tract infection, rhinitis, pharyngitis, rhinorrhea^[Ref]

Hematologic

Uncommon (0.1% to 1%): Neutropenia^[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis^[Ref]

Other

Uncommon (0.1% to 1%): Otitis externa^[Ref]

It is possible that some side effects of secukinumab may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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