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Secukinumab

Pronunciation: SEK-ue-KIN-ue-mab
Brand name: Cosentyx
Dosage form: Cosentyx Sensoready pen, Cosentyx prefilled syringes, Cosentyx single-dose vial
Drug class: Interleukin inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on May 16, 2025.

What is secukinumab?

Secukinumab (Cosentyx) is a prescription medication used to treat types of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, enthesitis-related arthritis, hidradenitis suppurativa (HS), and non-radiographic axial spondyloarthritis, which are autoimmune conditions. Secukinumab is a monoclonal antibody that targets interleukin-17A (IL-17A), a protein involved in the inflammatory process. Secukinumab helps reduce inflammation and related symptoms by blocking IL-17A.

Secukinumab brand name is Cosentyx by Novartis Pharmaceuticals Corporation.

Secukinumab is from the drug class interleukin (IL) inhibitors.

Secukinumab can be given as an injection under the skin (subcutaneous injection) for all conditions or as an intravenous infusion by your HCP for psoriatic arthritis (PsA), ankylosing spondylitis (AS), or non-radiographic axial spondyloarthritis (nr-axSPA). Secukinumab is often given as a weekly dose for the first 4 weeks, then monthly thereafter, however, the dose schedule may vary with age, administration type, or condition being treated.

Secukinumab FDA approval was received on January 21, 2015, for plaque psoriasis, and since then, other autoimmune conditions have been included. FDA approved secukinumab brand name is Cosentyx by Novartis Pharmaceuticals Corporation.

Secukinumab may improve your symptoms, but it may also lower the ability of your immune system to fight infections.

What is secukinumab used for?

Secukinumab is an FDA-approved medicine used to treat:

Secukinumab mechanism of action

The secukinumab mechanism of action is as an IL-17A blocker. Cosentyx works by targeting and blocking IL-17A, which helps calm down the immune system, reducing inflammation and improving symptoms.

In autoimmune conditions, the overactive immune system produces too much IL-17A, a protein that is believed to play a role in inflammation, pain, and damage, which causes the symptoms of these conditions.

Secukinumab side effects

Common secukinumab side effects

Common secukinumab side effects may include diarrhea or cold symptoms such as stuffy nose, sneezing, and sore throat.

Serious secukinumab side effects

Get emergency medical help if you have signs of an allergic reaction to secukinumab, including hives; chest tightness, difficulty breathing; feeling like you might pass out; and swelling of your face, lips, tongue, or throat.

Call your doctor right away if you have signs of infection such as

Further doses may be delayed until your infection clears up.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Warnings

You may get infections more easily while using secukinumab, as it lowers your immune system's ability to fight infections. Call your doctor right away if you have signs of infection such as fever, chills, sweats, muscle aches, skin sores, stomach pain, diarrhea, burning when you urinate, weight loss, cough, shortness of breath, or a cough with red or pink mucus.

Tell your doctor if you have an active infection or have ever been diagnosed with tuberculosis or inflammatory bowel disease before using this medicine.

Before using this medicine

You should not use secukinumab if you are allergic to it or any of the inactive ingredients contained in the medicine.

Tell your doctor if you've had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.

To make sure you can safely use secukinumab, tell your doctor if you have ever had:

Make sure you are current on all vaccines before you start using this medicine. You should not have any vaccinations during your treatment with secukinumab without first talking to your doctor.

Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if secukinumab can harm your unborn baby. You and your healthcare provider should decide if you will use this medicine.

Breastfeeding

Tell your doctor or healthcare professional if you are breastfeeding or plan to breastfeed. It is not known if secukinumab passes into your breast milk.

Secukinumab pregnancy and breastfeeding warnings (more detail)

How should I use secukinumab?

Secukinumab subcutaneous injection can be self-administered or administered by a caregiver in your own home. Pediatric patients should not self-administer this medicine, an adult caregiver can inject this medicine after proper training in subcutaneous injection technique.

Use secukinumab exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Ask your doctor or pharmacist if you don't understand how to use an injection.

Secukinumab can also be administered as an intravenous infusion by your healthcare professional (HCP) for psoriatic arthritis (PsA), ankylosing spondylitis (AS), or non-radiographic axial spondyloarthritis (nr-axSPA). Cosentyx intravenous infusion should be administered over a period of 30 minutes

Subcutaneous secukinumab

Secukinumab for self-administration at home is injected under the skin (subcutaneous injection).

You may get infections more easily, even serious infections. You will need frequent medical tests.

See the detailed “Instructions for Use” which for information and diagrams on how to prepare and inject a dose of secukinumab and how to properly throw away (dispose of) used secukinumab Sensoready pen and prefilled syringes.

Secukinumab Dosing Information

Secukinumab is supplied as a  Cosentyx Sensoready pen, Cosentyx prefilled syringe, or Cosentyx single-dose vial.

Intravenous dosing (administered by a healthcare provider)

Intravenous dosing can be used for psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis. Dilute before use. Administer infusion over 30 minutes.

Usual Adult Secukinumab Dose for Plaque Psoriasis

Dose:

Use: Moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy.

Usual Pediatric  Secukinumab Dose for Plaque Psoriasis (6 years and older)

Dose:

Use: Moderate to severe plaque psoriasis in pediatric patients 6 years and older who are candidates for systemic therapy or phototherapy.

Usual Adult Dose for Psoriatic Arthritis

Dose:

Comments:

Use: Active psoriatic arthritis.

Usual Pediatric Dose for Psoriatic Arthritis (2 years and older)

Dose:

Comment: This drug may be administered with or without methotrexate.

Use: Active psoriatic arthritis in patients 2 years and older.

Usual Adult Dose for Ankylosing Spondylitis

Dose:

Comment: If a patient continues to have active AS, consider a dosage of 300 mg every 4 weeks.

Uses: For active ankylosing spondylitis.

Usual Adult Dose for Non-Radiographic Axial Spondyloarthritis

Dose:

Use: Active non-radiographic axial spondyloarthritis (nr-axSpA) in adult patients who have objective signs of inflammation.

Usual Dose for Enthesitis-Related Arthritis 

Dose:

Use: Active enthesitis-related arthritis (ERA) in patients 4 years of age and older.

Usual Adult Dose for Hidradenitis Suppurativa: 

Dose:

Use: moderate to severe hidradenitis suppurativa (HS) in adults.

Cosentyx products

Subcutaneous Injection

Intravenous Infusion

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Cosentyx.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Secukinumab Package Insert 

HCPs and patients often use the Secukinumab Package Insert (PI) - Cosentyx for more detailed information about this medicine. The Package Insert contains more comprehensive information on Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies, Drug Interaction, and more. Discuss any medical questions you have with your HCP (health care professional). This is not all the information you need to know about this medicine for safe and effective use, and it does not take the place of talking to your doctor about your treatment.

The Package Insert is sometimes called Secukinumab Prescribing Information (PI) or FDA label.

Secukinumab J code

Secukinumab J code is J3247 (1 mg, intravenous).
J codes are used for medicines that are not taken orally and include injections, inhalations, and chemotherapies. J codes are important for accurate and consistent coding for billing and reimbursement purposes.

The secukinumab J code is only required for the intravenous infusion.

Your physician will need the Secukinumab J code when filling out forms for your treatment.

What should I avoid while using secukinumab?

Avoid receiving a "live" vaccine. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

What other drugs will affect secukinumab?

Secukinumab may interact with other products, so tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines you take and keep a list to show your healthcare provider and pharmacist when you start a new medicine or stop a regular medicine.

When starting or stopping this medicine for patients who are receiving a CYP450 substrate medicine, particularly those with a narrow therapeutic index, your therapeutic effect or drug concentration may be monitored, and you may need to have a dosage adjustment of the CYP450 substrate. Not all possible interactions are listed here. To check for interactions with secukinumab, click on the link below.

Does secukinumab interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Storage

What are the ingredients in secukinumab?

Active ingredient: secukinumab.

Inactive ingredients:

Cosentyx Sensoready pen and prefilled syringe: L-histidine/histidine hydrochloride monohydrate, L-methionine, polysorbate 80, trehalose dihydrate, and sterile water for injection.

Cosentyx Vial: L-histidine/histidine hydrochloride monohydrate, polysorbate 80, and sucrose.

Manufacturer:

Cosentyx is manufactured by: Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936.

Secukinumab Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for secukinumab.

Cosentyx (secukinumab) - Novartis Pharmaceuticals Corporation
Formulation type Strength
Autoinjector 150 mg/mL
Autoinjector 300 mg/2 mL
Pre-Filled Syringe 150 mg/mL
Pre-Filled Syringe 300 mg/2 mL Discontinued
Pre-Filled Syringe 75 mg/0.5 mL
Single-Dose Vial 125 mg/5 mL
Single-Dose Vial 150 mg Discontinued

View Cosentyx information in detail.

Popular FAQ

Cosentyx vs Humira: How do they compare?

Both Cosentyx and Humira are available as subcutaneous injections (which means given under the skin) and may be used to treat certain inflammatory conditions such as plaque psoriasis, psoriatic arthritis, hidradenitis suppurativa, and ankylosing spondylitis. Cosentyx is also available as an IV injection that can be administered by a healthcare provider. After an initial loading dose, Humira is given every two weeks and Cosentyx every four weeks. Continue reading

Is Cosentyx a biologic / immunosuppressant?

Yes, Cosentyx is a biologic and immunosuppressant medicine used to treat plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa, among other uses. Cosentyx may improve these medical conditions but can also lower your ability to fight infections because it is an immunosuppressant. Continue reading

Does Cosentyx have a black box warning?

No, Cosentyx does not contain a Boxed Warning, also commonly called a “Black Box Warning”. A Boxed Warning is the most serious safety drug warning issued by the FDA. Continue reading

More FAQ

View more FAQ

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.