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Taclonex Side Effects

Generic Name: betamethasone / calcipotriene topical

Note: This document contains side effect information about betamethasone / calcipotriene topical. Some of the dosage forms listed on this page may not apply to the brand name Taclonex.

For the Consumer

Applies to betamethasone/calcipotriene topical: topical application foam, topical application ointment, topical application suspension

Along with its needed effects, betamethasone/calcipotriene topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone/calcipotriene topical:

Less Common

  • Burning, itching, and pain in hairy areas
  • burning sensation of the skin
  • flushing or redness of the skin
  • itching skin
  • pus at the root of the hair
  • red, scaling, or crusted skin
  • scaly rash
  • skin irritation
  • thinning of the skin with easy bruising
  • unusually warm skin


  • Body aches or pain
  • chills
  • cough
  • darkening of the skin
  • diarrhea
  • difficulty with breathing
  • ear congestion
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • lightening of normal skin color
  • lightening of the treated areas of dark skin
  • loss of appetite
  • loss of voice
  • muscle aches and pains
  • nasal congestion
  • nausea
  • raised, dark red, or wart-like spots on skin
  • red, sore eyes
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • spots on your skin that look like a blister or pimple
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • worsening of the psoriasis

Some side effects of betamethasone / calcipotriene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Bruising
  • large, flat, blue, or purplish patches in the skin
  • pain


For Healthcare Professionals

Applies to betamethasone / calcipotriene topical: topical foam, topical ointment, topical suspension


Common (1% to 10%): Ointment: Pruritus (up to 7.2%), psoriasis (up to 3.4%), skin atrophy (up to 1.9%), folliculitis (up to 1.4%), skin depigmentation (1.4%), scaly rash (1.2%), hand dermatitis (1%); Suspension: Pruritus (3.6%), psoriasis (2.4%), erythema (2.1%), skin irritation (1.4%), folliculitis (up to 1.2%)

Uncommon (0.1% to 1%): Ointment: Erythema (up to 1%), skin irritation (0.4%), papular rash (greater than 0.1% and less than 1%), pustular rash (greater than 0.1% and less than 1%), skin hypopigmentation (greater than 0.1% and less than 1%), telangiectasia (0.1%), skin hyperpigmentation (0.1%); Suspension: Acne (greater than 0.1% and less than 1%), exacerbation of psoriasis (greater than 0.1% and less than 1%), rash (greater than 0.1% and less than 1%), pustular rash (greater than 0.1% and less than 1%)

Rare (less than 0.1%): Ointment: Serious flare-up of psoriasis (at least 1 case)

Postmarketing reports: Ointment: Pustular psoriasis[Ref]

Nervous system

Common (1% to 10%): Ointment: Headache (2.8%)[Ref]


Frequency not reported: Hypercalcemia, hypercalciuria[Ref]


Frequency not reported: Adrenal suppression; Ointment: Hypothalamic-pituitary-adrenal axis suppression[Ref]


Frequency not reported: Allergic contact dermatitis


Common (1% to 10%): Ointment: Nasopharyngitis (2.3%)

Uncommon (0.1% to 1%): Ointment: Influenza (0.9%), upper respiratory tract infection (0.8%)[Ref]


Common (1% to 10%): Ointment: Burning sensation (up to 1.4%); Suspension: Burning sensation of skin (1%)

Uncommon (0.1% to 1%): Ointment: Pain (0.3%)

Postmarketing reports: Ointment: Rebound effect[Ref]


Common (1% to 10%): Ointment: Ecchymosis (1%)[Ref]


Uncommon (0.1% to 1%): Ointment: Application site pruritus (0.5%)[Ref]


Uncommon (0.1% to 1%): Suspension: Eye irritation (greater than 0.1% and less than 1%)[Ref]


1. "Product Information. Taclonex (betamethasone-calcipotriene topical)." Warner Chilcott Laboratories, Rockaway, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.