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Pronunciation: EN-still-ar
Generic name: calcipotriene and betamethasone dipropionate
Dosage form: foam
Drug class: Topical antipsoriatics

Medically reviewed by Carmen Pope, BPharm. Last updated on May 31, 2023.

What is Enstilar?

Enstilar foam is a once-daily, topical, fixed-dose combination foam containing calcipotriene 0.005% (a vitamin D analog) and betamethasone dipropionate 0.064% (a corticosteroid) that may be used to treat plaque psoriasis in adults and children 12 years of age or older.

Enstilar foam is a stable supersaturated solution of calcipotriol/betamethasone dipropionate that has improved clinical efficacy and increased skin penetration compared with standard calcipotriol/betamethasone dipropionate ointments.

Enstilar was approved on October 16, 2015.


Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Hypercalcemia and hypercalciuria have been observed with the use of topical calcipotriene. If either occurs, discontinue Enstilar foam until laboratory values of calcium normalize.

Endocrine effects

The use of high-potency steroid products such as betamethasone dipropionate can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency during and after withdrawal of treatment. Risk factors include the use of high-potency topical corticosteroids, use over a large surface area, or to areas under occlusion, prolonged use, altered skin barrier, liver failure, and young age. Modify use of Enstilar foam should HPA axis suppression develop.

Ophthalmic Adverse Reactions

May increase the risk of cataracts and glaucoma. If visual symptoms occur, consider referral to an ophthalmologist.

Allergic contact dermatitis

May occur with either calcipotriene or betamethasone dipropionate topical use. May be observed as a failure to heal. Confirm with diagnostic patch testing.


Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects. Enstilar foam is not approved for use by anyone younger than 12 years old.

Before taking this medicine

You should not use Enstilar foam if you are allergic to calcipotriene, betamethasone dipropionate, or any other components of the foam.

Tell your doctor if you have ever had:


The use of high-potency topical steroid medicine during pregnancy may increase the risk of a low birth weight in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.


It may not be safe to breastfeed while using Enstilar. Ask your doctor about any risks. If you apply betamethasone and calcipotriene to your chest, avoid areas that may come into contact with the baby's mouth.

How is Enstilar foam used?

Enstilar should be applied once daily to the plaques for up to 4 weeks.

The contents of the Enstilar can are flammable and you should avoid being near sources of fire or flames, or smoking, immediately following application.

What are the side effects of Enstilar?

The most common side effects reported with Enstilar include irritation or itch at the application site, folliculitis, skin hypopigmentation, high calcium levels, urticaria, and exacerbation of psoriasis. 

Postmarketing studies with topical corticosteroids have reported atrophy, striae, telangiectasias, itching, dryness, hypopigmentation, perioral dermatitis, secondary infection, and miliaria.

Ophthalmic adverse reactions of cataracts, glaucoma, and increased intraocular pressure, have been reported during the use of topical corticosteroids, including topical betamethasone products.

What happens if I miss a dose?

Apply Enstilar foam as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.

High doses or long-term use of Enstilar can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using Enstilar?

Avoid using other skin medications that contain betamethasone or calcipotriene. Do not use Enstilar to treat any skin condition that has not been checked by your doctor.

Avoid getting the foam in your eyes or on your face, underarms, groin area, or areas of thin skin.

Enstilar foam could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Side effects can occur if your skin absorbs topical steroid medicine. Tell your doctor if you have:

Also, tell your doctor if you have:

What other drugs will affect Enstilar?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Enstilar foam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed.


Active ingredients: Each gram of Enstilar foam contains 52.2 mcg of calcipotriene hydrate (equivalent to 50 mcg of calcipotriene) and 0.643 mg of betamethasone dipropionate (equivalent to 0.5mg of betamethasone). It is available in 60-gram aluminum cans.

Inactive ingredients: white petrolatum PPG-11 stearyl ether, mineral oil, all-rac-alpha-tocopherol, and butylhydroxytoluene.

Propellants: dimethyl ether and butane.


Store between 20°C-25°C (68°F-77°F) and keep away from heat. Do not expose the can to a heat source or store it at temperatures above 49°C (120°F)

Do not puncture or burn the can. Do not freeze.

Do not use past the expiry date printed on the side of the can.

Discard any unused product 6 months after the can has been opened.

Keep out of reach of children.


Leo Pharma.

Popular FAQ

In studies, Enstilar Foam (calcipotriene / betamethasone dipropionate) has been used safely and effectively to treat plaque psoriasis on the body and scalp in adults and adolescents ages 12 to 17 years of age. Foam preparations are often preferred by patients with scalp psoriasis (over ointments or thick creams) and the ingredients in Enstilar Foam are considered standard first-line treatments. Continue reading

Enstilar is a topical spray foam applied to the skin to treat plaque psoriasis. It contains calcipotriene, a vitamin D analog, and betamethasone dipropionate, a potent corticosteroid. Enstilar is used on the skin for up to 4 weeks in people 12 years and older. Continue reading

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.