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Enstilar Side Effects

Generic Name: betamethasone / calcipotriene topical

Note: This page contains information about the side effects of betamethasone / calcipotriene topical. Some of the dosage forms included on this document may not apply to the brand name Enstilar.

For the Consumer

Applies to betamethasone / calcipotriene topical: topical application foam, topical application ointment, topical application suspension

In addition to its needed effects, some unwanted effects may be caused by betamethasone / calcipotriene topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking betamethasone / calcipotriene topical:

Less common:
  • Burning, itching, and pain in hairy areas
  • burning sensation of the skin
  • flushing or redness of the skin
  • itching skin
  • pus at the root of the hair
  • red, scaling, or crusted skin
  • scaly rash
  • skin irritation
  • thinning of the skin with easy bruising
  • unusually warm skin
  • Body aches or pain
  • chills
  • cough
  • darkening of the skin
  • diarrhea
  • difficulty with breathing
  • ear congestion
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • lightening of normal skin color
  • lightening of the treated areas of dark skin
  • loss of appetite
  • loss of voice
  • muscle aches and pains
  • nasal congestion
  • nausea
  • raised, dark red, or wart-like spots on skin
  • red, sore eyes
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • spots on your skin that look like a blister or pimple
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • worsening of the psoriasis

Minor Side Effects

Some of the side effects that can occur with betamethasone / calcipotriene topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Bruising
  • large, flat, blue, or purplish patches in the skin
  • pain
  • Blemishes on the skin
  • pimples

For Healthcare Professionals

Applies to betamethasone / calcipotriene topical: topical foam, topical ointment, topical suspension


Common (1% to 10%): Ointment: Pruritus (up to 7.2%), psoriasis (up to 3.4%), skin atrophy (up to 1.9%), folliculitis (up to 1.4%), skin depigmentation (1.4%), scaly rash (1.2%), hand dermatitis (1%); Suspension: Pruritus (3.6%), psoriasis (2.4%), erythema (2.1%), skin irritation (1.4%), folliculitis (up to 1.2%)
Uncommon (0.1% to 1%): Ointment: Erythema (up to 1%), skin irritation (0.4%), papular rash (greater than 0.1% and less than 1%), pustular rash (greater than 0.1% and less than 1%), skin hypopigmentation (greater than 0.1% and less than 1%), telangiectasia (0.1%), skin hyperpigmentation (0.1%); Suspension: Acne (greater than 0.1% and less than 1%), exacerbation of psoriasis (greater than 0.1% and less than 1%), rash (greater than 0.1% and less than 1%), pustular rash (greater than 0.1% and less than 1%)
Rare (less than 0.1%): Ointment: Serious flare-up of psoriasis (at least 1 case)
Postmarketing reports: Ointment: Pustular psoriasis[Ref]

Nervous system

Common (1% to 10%): Ointment: Headache (2.8%)[Ref]


Frequency not reported: Hypercalcemia, hypercalciuria[Ref]


Frequency not reported: Adrenal suppression; Ointment: Hypothalamic-pituitary-adrenal axis suppression[Ref]


Frequency not reported: Allergic contact dermatitis


Common (1% to 10%): Ointment: Nasopharyngitis (2.3%)
Uncommon (0.1% to 1%): Ointment: Influenza (0.9%), upper respiratory tract infection (0.8%)[Ref]


Common (1% to 10%): Ointment: Burning sensation (up to 1.4%); Suspension: Burning sensation of skin (1%)
Uncommon (0.1% to 1%): Ointment: Pain (0.3%)
Postmarketing reports: Ointment: Rebound effect[Ref]


Common (1% to 10%): Ointment: Ecchymosis (1%)[Ref]


Uncommon (0.1% to 1%): Ointment: Application site pruritus (0.5%)[Ref]


Uncommon (0.1% to 1%): Suspension: Eye irritation (greater than 0.1% and less than 1%)[Ref]


1. "Product Information. Taclonex (betamethasone-calcipotriene topical)." Warner Chilcott Laboratories, Rockaway, NJ.

Not all side effects for Enstilar may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.