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Tremfya Side Effects

Generic name: guselkumab

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 17, 2024.

Note: This document contains side effect information about guselkumab. Some dosage forms listed on this page may not apply to the brand name Tremfya.

Applies to guselkumab: subcutaneous solution.

Serious side effects of Tremfya

Along with its needed effects, guselkumab (the active ingredient contained in Tremfya) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking guselkumab:

More common

Less Common


Other side effects of Tremfya

Some side effects of guselkumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


For Healthcare Professionals

Applies to guselkumab: subcutaneous solution.


Very common (10% or more): Infections (23%)

Common (1% to 10%): Tinea infections, herpes simplex infections, immunogenicity[Ref]


Common (1% to 10%): Injection site reactions (e.g., injection site erythema, bruising, hematoma, hemorrhage, swelling, edema, pruritus, pain, discoloration, induration, inflammation, urticaria)[Ref]


Common (1% to 10%): Arthralgia[Ref]


Common (1% to 10%): Elevated liver enzymes[Ref]


Very common (10% or more): Respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, viral upper respiratory tract infection) (14%)[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Common (1% to 10%): Diarrhea, gastroenteritis (including viral gastroenteritis)[Ref]


Uncommon (0.1% to 1%): Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]


Common (1% to 10%): Urticaria, rash[Ref]

Frequently asked questions


1. (2017) "Product Information. Tremfya (guselkumab)." Janssen Biotech, Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.