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Apremilast Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 14, 2022.


Commonly reported side effects of apremilast include: weight loss. Other side effects include: diarrhea, headache, and nausea. Continue reading for a comprehensive list of adverse effects.

Applies to apremilast: oral tablets.

Side effects include:

Adverse events reported in ≥5% of patients with psoriatic arthritis: Diarrhea, nausea, and headache.

Adverse events reported in ≥5% of patients with psoriasis: Diarrhea, nausea, upper respiratory tract infection, and headache (including tension headache).

Adverse effects reported in ≥10% of patients with Behçet disease: Diarrhea, nausea, headache, and upper respiratory tract infection.

For Healthcare Professionals

Applies to apremilast: oral tablet.


The most commonly reported side effects included diarrhea, headache, and nausea.[Ref]


Frequency not reported: Hypersensitivity[Ref]


Common (1% to 10%): Diarrhea, nausea, vomiting, upper abdominal pain

Frequency not reported: Frequent bowel movement, gastroesophageal reflux disease, dyspepsia[Ref]


Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis

Frequency not reported: Cough[Ref]


Frequency not reported: Rash[Ref]


Frequency not reported: Weight decrease, decreased appetite[Ref]

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Migraine[Ref]

Frequently asked questions


1. "Product Information. Otezla (apremilast)." Celgene Corporation (2014):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.