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Apremilast Side Effects

For the Consumer

Applies to apremilast: oral tablet

Along with its needed effects, apremilast may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking apremilast:

Rare
  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • tiredness
  • trouble concentrating
  • trouble sleeping
Incidence not known
  • Fast heartbeat
  • fever
  • hives, itching, rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • weight loss

Some side effects of apremilast may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • chills
  • cough
  • diarrhea
  • ear congestion
  • headache
  • headache, severe and throbbing
  • loss of voice
  • nausea
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common
  • Back pain
  • belching
  • burning, itching, pain in the hairy areas, pus at the root of the hair
  • decreased appetite
  • heartburn
  • indigestion
  • muscle aches
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain
  • vomiting

For Healthcare Professionals

Applies to apremilast: oral tablet

General

The most commonly reported side effects included diarrhea, headache, and nausea.[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, vomiting, upper abdominal pain
Frequency not reported: Frequent bowel movement, gastroesophageal reflux disease, dyspepsia[Ref]

Respiratory

Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis
Frequency not reported: Cough[Ref]

Dermatologic

Frequency not reported: Rash[Ref]

Metabolic

Frequency not reported: Weight decrease, decreased appetite[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Migraine[Ref]

References

1. "Product Information. Otezla (apremilast)." Celgene Corporation, Summit, NJ.

Some side effects of apremilast may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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