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Apremilast Dosage

Medically reviewed on October 9, 2017.

Applies to the following strengths: 10 mg-20 mg-30 mg; 30 mg

Usual Adult Dose for Psoriatic Arthritis

Initial dose:
-Day 1: 10 mg orally once a day (AM)
-Day 2: 10 mg orally twice a day (AM and PM)
-Day 3: 10 mg orally once a day (AM); 20 mg orally once a day (PM)
-Day 4: 20 mg orally twice a day (AM and PM)
-Day 5: 20 mg orally once a day (AM); 30 mg orally once a day (PM)

Maintenance dose: 30 mg orally twice a day (AM and PM)

Comments: This titration is intended to reduce the gastrointestinal symptoms associated with initial therapy.

Use: Treatment of adult patients with active psoriatic arthritis

Renal Dose Adjustments

Mild to moderate renal impairment: Data not available.
Severe renal impairment (CrCl less than 30 mL/min):
-Initial dosage: Titrate using only the AM schedule listed above and skip the PM doses.
-Maintenance dose: 30 mg orally once a day (AM)

Liver Dose Adjustments

No adjustment recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Administer without regard to meals.
-Do not crush, split, or chew the tablets.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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