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Skyrizi Side Effects

Generic name: risankizumab

Medically reviewed by Drugs.com. Last updated on April 4, 2020.

Note: This document contains side effect information about risankizumab. Some of the dosage forms listed on this page may not apply to the brand name Skyrizi.

For the Consumer

Applies to risankizumab: subcutaneous solution

Side effects requiring immediate medical attention

Along with its needed effects, risankizumab (the active ingredient contained in Skyrizi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking risankizumab:

More common

  • Body aches or pain
  • chest pain
  • chills
  • confusion
  • cough
  • difficulty in breathing
  • dizziness
  • ear congestion
  • fainting
  • fast heartbeat
  • fever
  • headache
  • increase in bone pain
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • lightheadedness
  • loss of voice
  • painful blisters on the trunk of the body
  • rapid, shallow breathing
  • runny or stuffy nose
  • sneezing
  • sore throat
  • tightness in the chest
  • unusual tiredness or weakness

Less common

  • Itching of the genitals or other skin areas
  • scaling of the skin

Rare

  • Burning, itching, and pain in hairy areas, pus at the root of the hair
  • hives or welts, itching, skin rash

Side effects not requiring immediate medical attention

Some side effects of risankizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to risankizumab: subcutaneous kit

Immunologic

Very common (10% or more): Immunogenicity (24%), infections (e.g., cellulitis, osteomyelitis, sepsis, herpes zoster) (22%)

Common (1% to 10%): Tinea infections (e.g., tinea pedis, tinea cruris, body tinea, tinea versicolor, tinea manuum, tinea infection)[Ref]

Local

Common (1% to 10%): Injection site reactions (e.g., bruising, erythema, extravasation, hematoma, hemorrhage, infection, inflammation, irritation, pain, pruritus, reaction, swelling, warmth)[Ref]

Respiratory

Very common (10% or more): Upper respiratory infections (e.g., respiratory tract infection [viral, bacterial, unspecified], sinusitis [including acute], rhinitis, nasopharyngitis, pharyngitis [including viral], tonsillitis) (13%)[Ref]

Other

Common (1% to 10%): Fatigue, asthenia[Ref]

Nervous system

Common (1% to 10%): Headache (e.g., tension headache, sinus headache, cervicogenic headache)[Ref]

Dermatologic

Uncommon (0.1% to 1%): Folliculitis, urticaria[Ref]

References

1. "Product Information. Skyrizi (risankizumab)." AbbVie US LLC, North Chicago, IL.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.