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Skyrizi: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on July 13, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Skyrizi is an interleukin inhibitor that may be used to reduce inflammation-associated plaque psoriasis, psoriatic arthritis, or Crohn's disease in adults. The usual dosage is 150mg every 12 weeks consisting of two 75mg subcutaneous injections and people can be taught how to self-administer. Upper respiratory tract infections, headaches, and fatigue are the most commonly reported side effects.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Skyrizi may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Skyrizi. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with Skyrizi include:

There is a potential for any medication that is metabolized by CYP450 enzymes, particularly those with a narrow therapeutic index (such as cyclosporine or warfarin) to interact with Skyrizi. This is because the formation of CYP450 enzymes can be altered by increased levels of certain cytokines (such as IL-23) during chronic inflammation. Because Skyrizi stops IL-23 from interacting with their receptors, this could normalize the formation of CYP450 enzymes. Monitor for any change in effect and consider dosage modification.

Note that this list is not all-inclusive and includes only common medications that may interact with Skyrizi. You should refer to the prescribing information for Skyrizi for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Skyrizi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: July 12, 2023.