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Tolectin DS Side Effects

Generic name: tolmetin

Medically reviewed by Last updated on Aug 25, 2023.

Note: This document contains side effect information about tolmetin. Some dosage forms listed on this page may not apply to the brand name Tolectin DS.

Applies to tolmetin: oral capsule, oral tablet.


Oral route (Tablet; Capsule)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased with duration of use and in patients with cardiovascular disease or risk factors for cardiovascular disease. Tolmetin is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious, sometimes fatal, gastrointestinal adverse events (eg, bleeding, ulceration, and perforation of the stomach or intestines), especially in the elderly. These events can occur at any time during use and without warning.

Serious side effects of Tolectin DS

Along with its needed effects, tolmetin (the active ingredient contained in Tolectin DS) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tolmetin:

More common

Less common


Other side effects of Tolectin DS

Some side effects of tolmetin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to tolmetin: oral capsule, oral tablet.


Very common (10% or more): Nausea (11%)

Common (1% to 10%): Dyspepsia, gastrointestinal (GI) distress, abdominal pain, diarrhea, flatulence, vomiting, constipation, gastritis, peptic ulcer

Frequency not reported: GI bleeding, GI perforation, glossitis, stomatitis[Ref]


Frequency not reported: Hepatitis, liver function abnormalities[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, drowsiness[Ref]


Common (1% to 10%): Hemoglobin decreased, hematocrit decreased

Frequency not reported: Lymphadenopathy, hemolytic anemia, thrombocytopenia, granulocytopenia, agranulocytosis[Ref]


Common (1% to 10%): BUN increased

Frequency not reported: Renal failure[Ref]


Frequency not reported: Anaphylactoid reactions[Ref]


Common (1% to 10%): Skin irritation

Frequency not reported: Urticaria, purpura, erythema multiforme, toxic epidermal necrolysis[Ref]


Common (1% to 10%): Blood pressure increased

Frequency not reported: Congestive heart failure[Ref]


The most frequently reported side effect was nausea.[Ref]


Common (1% to 10%): Urinary tract infection

Frequency not reported: Hematuria, proteinuria, dysuria[Ref]


Frequency not reported: Serum sickness


Common (1% to 10%): Visual disturbance

Frequency not reported: Optic neuropathy, retinal/macular changes[Ref]


Common (1% to 10%): Asthenia, chest pain, edema, weight gain, weight loss, tinnitus

Frequency not reported: Fever[Ref]


Common (1% to 10%): Depression[Ref]


Frequency not reported: Epistaxis[Ref]


1. (2001) "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.