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User Reviews for Sulfasalazine

Also known as: Azulfidine, Azulfidine EN-tabs

Sulfasalazine has an average rating of 5.2 out of 10 from a total of 125 ratings on Drugs.com. 41% of reviewers reported a positive experience, while 43% reported a negative experience.

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Summary of Sulfasalazine reviews 5.2 125 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Sulfasalazine

Jamie · Taken for 1 to 6 months · December 11, 2019

For Rheumatoid Arthritis: “I've dealt with joint pains and swelling of my joints that on and off forced me to use crutches at only 22 years old. (And several other symptoms) Predinisone was the only medication helping me deal with the worst of my pains. My doctor suggested I start taking sulfasalazine about 5 months ago and I was shocked at my results. I haven't felt this healthy in a very long time. Sulfasalazine helped me getting my life back and I am so grateful for my results. I've had no side effects that Ive noticed except for the headaches I got when I started taking the medication.”

10 / 10
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Runnergirl · Taken for 1 to 2 years · October 25, 2019

Azulfidine (sulfasalazine) for Rheumatoid Arthritis: “56 yo female diagnosed with RA two years ago. Before the diagnosis I had severe pain in my hands, arms, shoulders, knees, ankles and legs. I really thought I was going in the direction of a wheelchair. I had been a runner but never thought I would run again. After about six months of being on the medicine Azilfidine I was able to start running again. This year in July, I qualified for the Boston Marathon! Something I’ve only dreamt about, thank you so much for the medicine!!”

10 / 10
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MarkMan · Taken for 10 years or more · March 3, 2014

For Rheumatoid Arthritis: “I have been taking sulfasalazine for 19 years, the age of my son. As a baby I could not lift him, my wrists were too painful. My rheumatoid arthritis was in 15 joints, symmetrical, etc. I was on the Dutch COBRA study, combining sulfasalazine, methotrexate and prednisone, except I was in the placebo group getting only sulfasalazine. It kicked in after 6 weeks and do far has worked well. Some issues with my left foot started a year ago, but it doesn't stop me hiking in The Alps for a week.”

10 / 10
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vaibhavr · February 3, 2014

For Rheumatoid Arthritis: “I have been on it since 2009 due to severe back pain. I was told I have ankylosing spondilitis, a disease which affects joints. But this medicine improved my condition up to the point that I can lead a normal life again.”

9 / 10
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Dbestdeb · March 7, 2014

For Rheumatoid Arthritis: “Have been on sulfasalazine for a year since being diagnosed with rheumatoid arthritis. I am grateful to have it since other medicines aren't an option for me due to unexplained elevated liver enzymes. It has helped the pain of rheumatoid arthritis quite a lot and my inflammation has gone down. I just wish it addressed the fatigue.”

7 / 10
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caseey14 · December 11, 2016

For Rheumatoid Arthritis: “I was diagnosed with RA when I was 10 years old. I was prescribed methotrexate originally and that worked well. But when I reached 21, I wanted to come off of it because I wanted to be able to consume alcohol. I was then prescribed sulfasalazine and found that this worked just as well as methotrexate. The only downfall was how long it took to kick in and relieve my symptoms. After taking sulfasalazine for a little over a year, I went into remission for 3 years. But this week my jaw is very stiff and hurts pretty bad so I started back up on sulfasalazine (2 pills in the morning, 2 pills at night). I have no side effects. For those who get nausea from sulfasalazine-folic acid really helps with that. I highly recommend this medication.”

10 / 10
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Pusheen · Taken for 6 months to 1 year · December 17, 2016

For Rheumatoid Arthritis: “Initially caused severe headaches upon waking. The headaches responded well to Tylenol. Took months to become effective at all and after that my rheumy doubled my dose which took even more months. Total time to achieve a tolerable level of inflammation was 7 months. I finally feel like a more "normal" person again. It is not 100% effective but I am satisfied as I do not need to take anything else like an NSAID or other pain meds. any more. I'm glad I didn't give up on it as it is working and is considered one of the more benign DMARDs available. I suffer from inflammatory arthritis (nonspecific/not RA). Check into turmeric (golden paste) to help with inflammation. Praying for a cure for all!”

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Peggy90 · Taken for less than 1 month · September 10, 2019

For Rheumatoid Arthritis: “I’ve been on the good injection for years which has been amazing. Due to it not been sold anymore, they have put me on Sulfasalizine I’m on 3 a day now and have constant headaches, pain in my neck no energy at all And loss of appetite. I’m dreading taking 4 next week. I just hope my body can adjust to the medication and no side affects”

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Sandra · Taken for less than 1 month · May 23, 2019

For Rheumatoid Arthritis: “It’s only been a few weeks, and sulfasalazine has has stopped the shooting pain in my wrist, along with bad cramping in my fingers and thumb, that was waking me up at night. While the swelling in my hands and feet hasn’t gone down much, I’m enjoying the relief and feel grateful. I just now started the two-a-days but am optimistic about my ability to stay active. I’ve only experienced a little nausea so far, and it’s worth it. Headed to the gym to see what I can do!”

8 / 10
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SGM · May 6, 2014

For Rheumatoid Arthritis: “Rheumatoid arthritis since 1994, pretty severe case. Had to stop taking Humira and methotrexate due to repeated bouts with pneumonia and lung damage. Currently on sulfasalazine, Plaquenil and prednisone. Occasional flares but things are basically back under control.”

6 / 10
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Anonymous · October 24, 2010

Sulfazine (sulfasalazine) for Rheumatoid Arthritis: “Been on sulfasalazine for 3 years, for me the first 2 weeks were hard on the stomach. Felt like I was going to vomit all the time but never did, it was slow to have the effect maybe a month, but after that it has been good. Still get flare up the odd time. It is inexpensive compared to the other medications.”

9 / 10
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thetwoofus · June 25, 2011

For Rheumatoid Arthritis: “Diagnosed with rheumatoid arthritis 18 months ago, been on sulfasalazine all time. First 2 months felt sick and headachey, but okay since. Found ringing in ears relieved by having high pillows, i.e. two good ones and a very soft lesser one. Visit Rheumatologist every 6 months, with blood tests every 3 months. Carpel tunnel was very bad prior to taking sulfasalazine. Much better now; keeping well.”

9 / 10
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taydye4 · May 14, 2018

For Rheumatoid Arthritis: “After 6 months of symptoms I was diagnosed with RA 5 weeks ago and started this medication immediately. The pain was primarily affecting my feet, ankles, and toes, and I had been totally unable to walk for the whole 6 months. After about 3 weeks I noticed a major improvement. Although I still had pain, the locked-up stiffness was totally gone which meant I could walk again. Today, after 5 weeks, the pain is drastically improved and I hope this continues. Today I went out to see how far I could walk, and I made it 4 kms. I also experienced no side effects coming onto this medication. I would also suggest anyone with RA check out the Paddison program. Clint Paddison developed very severe RA at 31 and got to full remission and off of all of his medications in only two years. You can do it too!!”

10 / 10
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Anonymous · May 16, 2012

For Rheumatoid Arthritis: “I've taken sulfasalazine for four months (1000 MG twice per day). It took at least six weeks to become effective, but combined with Etodolac, an anti-inflammatory, I have had good success with controlling a mono-arthritic knee that had been diagnosed as rheumatoid arthritis after almost 20 years of problems, various surgeries, etc. I worry about side-effects, but the pain and extreme swelling is controlled after many years.”

7 / 10
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Cbshah · January 22, 2018

For Rheumatoid Arthritis: “I’ve been on sulfasalazine for RA for about 10 weeks. I increased the dose gradually over 3 weeks. Once I reached the full dose (2000 mg/day) I started noticing side effects. Mostly headaches/nausea. I decided to try to stick it out and I’m so glad I did. Eventually side effects went away as I adjusted to the med. Over the past week I’ve felt better than I have in years! Still have joints that sore, but the symptoms I have are very mild compared to what they once were. Hoping this continues to improve over the next few months.”

9 / 10
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Becca · Taken for less than 1 month · November 17, 2020

For Rheumatoid Arthritis: “No benefits of using sulfasalazine for RA. Just stomach pain, asthma, depression, anxiety and a constant feeling of impending doom. Strange, but I'm post- menopausal and had menstrual bleeding after 1 week on sulfasalazine. All of this stopped when I stopped taking this drug”

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pinkhairedanalyst · Taken for 1 to 6 months · October 1, 2019

For Psoriatic Arthritis: “My doc started me on this since it’s the weakest medication with the least amount of side effects you can be on for autoimmune conditions. Docs aren’t fond of methotrexate in young adult females either (I’m a 23 year old female). I have PsA, and it’s a night and day difference with this medication. I take 3 pills twice daily. My inflammation markers have decreased by 7 points and .2 points on the other. Life changing medication and I no longer feel like garbage. If you don’t like the idea of side effects, start with this first. Every body processes medications different, but you don’t know until you try it.”

10 / 10
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Inflame62 · Taken for 2 to 5 years · April 16, 2020

For Rheumatoid Arthritis: “Been on this sulfasalazine for RA for 4 years have now and for last 6 months sharp cramping pain in stomach right of navel. I don’t if anyone else has had this problem plus pain under left rib. Seriously thinking of packing it in joints no improvement either also dry itchy upper feet. Also been taking it without folic acid a which is advisable apparently , but which I didn’t know about.This drug can cause folate deficiency and vit-b12 deficiency too.Horrible drug.”

3 / 10
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Kjay · Taken for 6 months to 1 year · July 8, 2019

For Rheumatoid Arthritis: “Diagnosed with RA 2013. Managed on hydroxy & kenalog injections until last year when wrists, neck & knees were in constant pain. Started on sulphasalazine last September - kenalog injection initially reduced pain & swelling until it kicked in & apart from a couple of blood issues sulfasalazine has been great. No daily side effects at all but when reached 4 daily my neutrophils decreased to an unacceptable low. I’m now settled on 3/day rather than 4 & it’s seems to be working for me.”

8 / 10
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Susanne35Cat · July 6, 2011

Sulfazine (sulfasalazine) for Rheumatoid Arthritis: “I have Rheumatoid Arthritis and have been using Sulfasalazine for the last 4 years as an "add-on" to methotrexate. I take the maximum dose, but must confess that I can only see a minimal reduction of pain using this medicine. ”

5 / 10
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Jbm61 · June 25, 2014

For Psoriatic Arthritis: “After being on methotrexate and Humira I experienced no relief as well as a SEVERE LIFE THREATENING episode called Ludwigs Angina, ended up in a coma for 4 days, and was told if I had waited 1/2 hr longer to go to ER, I probably wouldn't have survived! I swore off all arthritic medicines for a year, except for pain medicines. Rheumatologist understood, and after a year suggested we start back very passively as opposed to aggressively to treatment. She suggested SSZ (sulfasalazine) and I reluctantly agreed. I was told it could take up to 3-4 months before I would see any improvement. Within 3 weeks I felt like a new person, I've been on it for a year and feel wonderful!”

10 / 10
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Moggie 1 · February 26, 2015

For Rheumatoid Arthritis: “My reaction was unusual! After the second week I began to get daily severe headaches and raised temperature, after the third week my temperature was quite high, still severe headaches, doctor thought it was an infection, blood tests showed extremely high CRP, ESR and raised liver enzymes, also extremely low blood pressure. I was taken off sulfasalazine and treated with antibiotics, improved quickly, recommenced medicine and had exactly the same reaction within aweek!”

1 / 10
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Lora S. · Taken for 1 to 2 years · May 15, 2013

For Psoriatic Arthritis: “I LOVE THIS MEDICINE! I had tried many medicines before this including methotrexate which was HORRIBLE-they all made me so ill. I only had loose stools at the start of treatment as a side effect, no others. I take it alone, without NSAIDs and it manages all my pain and swelling like a champ. I have had no flares and I take 2 in the morning and 2 in the evening. My hair also stopped falling out after the 1st 2 months of taking it. It literally changed my life without shutting down my immune system. I could not be happier.”

10 / 10
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karenbuff · April 11, 2010

Sulfazine (sulfasalazine) for Rheumatoid Arthritis: “I have had a small improvement with sulfazine, but unfortunately I started having severe ringing in the ears after 6 months, also it gave me pain in my achilles tendon and calves at night. Keep in mind that I had the pain side effect also with cholestrol medications, but not the ringing in the ears.”

4 / 10
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mygoldens · April 25, 2016

For Rheumatoid Arthritis: “I have only been on this med for 4 months. It has helped with my stiffness. My body would become so stiff, felt like I had pre death rigormortis... especially after sitting for any length of time. Getting up from a sitting position was extremely painful and awkward. My only complaint about the med is that it is to large for me to swallow. I take 3 per day, and I am fearful that I will choke on them. They scrape my throat and esophagus when I take them. Wish they would change the shape and coat them to make them easier to take.”

8 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.