Skip to main content

User Reviews for Sulfasalazine to treat Rheumatoid Arthritis

Also known as: Azulfidine, Azulfidine EN-tabs

Sulfasalazine has an average rating of 4.8 out of 10 from a total of 56 ratings for the treatment of Rheumatoid Arthritis. 32% of reviewers reported a positive effect, while 50% reported a negative effect.

Sulfasalazine Rating Summary

4.8/10 average rating

56 ratings from 65 user reviews.

Compare all 305 medications used in the treatment of Rheumatoid Arthritis.

10
14%
9
11%
8
7%
7
4%
6
5%
5
4%
4
5%
3
13%
2
9%
1
29%

Reviews for Sulfasalazine

Jamie · Taken for 1 to 6 months December 11, 2019

“I've dealt with joint pains and swelling of my joints that on and off forced me to use crutches at only 22 years old. (And several other symptoms) Predinisone was the only medication helping me deal with the worst of my pains. My doctor suggested I start taking sulfasalazine about 5 months ago and I was shocked at my results. I haven't felt this healthy in a very long time. Sulfasalazine helped me getting my life back and I am so grateful for my results. I've had no side effects that Ive noticed except for the headaches I got when I started taking the medication.”

10 / 10
Was this helpful?YesNo
Runnergirl · Taken for 1 to 2 years October 25, 2019

Azulfidine (sulfasalazine): “56 yo female diagnosed with RA two years ago. Before the diagnosis I had severe pain in my hands, arms, shoulders, knees, ankles and legs. I really thought I was going in the direction of a wheelchair. I had been a runner but never thought I would run again. After about six months of being on the medicine Azilfidine I was able to start running again. This year in July, I qualified for the Boston Marathon! Something I’ve only dreamt about, thank you so much for the medicine!!”

10 / 10
Was this helpful?YesNo
MarkMan · Taken for 10 years or more March 3, 2014

“I have been taking sulfasalazine for 19 years, the age of my son. As a baby I could not lift him, my wrists were too painful. My rheumatoid arthritis was in 15 joints, symmetrical, etc. I was on the Dutch COBRA study, combining sulfasalazine, methotrexate and prednisone, except I was in the placebo group getting only sulfasalazine. It kicked in after 6 weeks and do far has worked well. Some issues with my left foot started a year ago, but it doesn't stop me hiking in The Alps for a week.”

10 / 10
Was this helpful?YesNo
vaibhavr February 3, 2014

“I have been on it since 2009 due to severe back pain. I was told I have ankylosing spondilitis, a disease which affects joints. But this medicine improved my condition up to the point that I can lead a normal life again.”

9 / 10
Was this helpful?YesNo
Dbestdeb March 7, 2014

“Have been on sulfasalazine for a year since being diagnosed with rheumatoid arthritis. I am grateful to have it since other medicines aren't an option for me due to unexplained elevated liver enzymes. It has helped the pain of rheumatoid arthritis quite a lot and my inflammation has gone down. I just wish it addressed the fatigue.”

7 / 10
Was this helpful?YesNo
caseey14 December 11, 2016

“I was diagnosed with RA when I was 10 years old. I was prescribed methotrexate originally and that worked well. But when I reached 21, I wanted to come off of it because I wanted to be able to consume alcohol. I was then prescribed sulfasalazine and found that this worked just as well as methotrexate. The only downfall was how long it took to kick in and relieve my symptoms. After taking sulfasalazine for a little over a year, I went into remission for 3 years. But this week my jaw is very stiff and hurts pretty bad so I started back up on sulfasalazine (2 pills in the morning, 2 pills at night). I have no side effects. For those who get nausea from sulfasalazine-folic acid really helps with that. I highly recommend this medication.”

10 / 10
Was this helpful?YesNo
Sandra · Taken for less than 1 month May 23, 2019

“It’s only been a few weeks, and sulfasalazine has has stopped the shooting pain in my wrist, along with bad cramping in my fingers and thumb, that was waking me up at night. While the swelling in my hands and feet hasn’t gone down much, I’m enjoying the relief and feel grateful. I just now started the two-a-days but am optimistic about my ability to stay active. I’ve only experienced a little nausea so far, and it’s worth it. Headed to the gym to see what I can do!”

8 / 10
Was this helpful?YesNo
Pusheen · Taken for 6 months to 1 year December 17, 2016

“Initially caused severe headaches upon waking. The headaches responded well to Tylenol. Took months to become effective at all and after that my rheumy doubled my dose which took even more months. Total time to achieve a tolerable level of inflammation was 7 months. I finally feel like a more "normal" person again. It is not 100% effective but I am satisfied as I do not need to take anything else like an NSAID or other pain meds. any more. I'm glad I didn't give up on it as it is working and is considered one of the more benign DMARDs available. I suffer from inflammatory arthritis (nonspecific/not RA). Check into turmeric (golden paste) to help with inflammation. Praying for a cure for all!”

Was this helpful?YesNo
Anonymous October 24, 2010

Sulfazine (sulfasalazine): “Been on sulfasalazine for 3 years, for me the first 2 weeks were hard on the stomach. Felt like I was going to vomit all the time but never did, it was slow to have the effect maybe a month, but after that it has been good. Still get flare up the odd time. It is inexpensive compared to the other medications.”

9 / 10
Was this helpful?YesNo
Peggy90 · Taken for less than 1 month September 10, 2019

“I’ve been on the good injection for years which has been amazing. Due to it not been sold anymore, they have put me on Sulfasalizine I’m on 3 a day now and have constant headaches, pain in my neck no energy at all And loss of appetite. I’m dreading taking 4 next week. I just hope my body can adjust to the medication and no side affects”

Was this helpful?YesNo
SGM May 6, 2014

“Rheumatoid arthritis since 1994, pretty severe case. Had to stop taking Humira and methotrexate due to repeated bouts with pneumonia and lung damage. Currently on sulfasalazine, Plaquenil and prednisone. Occasional flares but things are basically back under control.”

6 / 10
Was this helpful?YesNo
Becca · Taken for less than 1 month November 17, 2020

“No benefits of using sulfasalazine for RA. Just stomach pain, asthma, depression, anxiety and a constant feeling of impending doom. Strange, but I'm post- menopausal and had menstrual bleeding after 1 week on sulfasalazine. All of this stopped when I stopped taking this drug”

Was this helpful?YesNo
thetwoofus June 25, 2011

“Diagnosed with rheumatoid arthritis 18 months ago, been on sulfasalazine all time. First 2 months felt sick and headachey, but okay since. Found ringing in ears relieved by having high pillows, i.e. two good ones and a very soft lesser one. Visit Rheumatologist every 6 months, with blood tests every 3 months. Carpel tunnel was very bad prior to taking sulfasalazine. Much better now; keeping well.”

9 / 10
Was this helpful?YesNo
taydye4 May 14, 2018

“After 6 months of symptoms I was diagnosed with RA 5 weeks ago and started this medication immediately. The pain was primarily affecting my feet, ankles, and toes, and I had been totally unable to walk for the whole 6 months. After about 3 weeks I noticed a major improvement. Although I still had pain, the locked-up stiffness was totally gone which meant I could walk again. Today, after 5 weeks, the pain is drastically improved and I hope this continues. Today I went out to see how far I could walk, and I made it 4 kms. I also experienced no side effects coming onto this medication. I would also suggest anyone with RA check out the Paddison program. Clint Paddison developed very severe RA at 31 and got to full remission and off of all of his medications in only two years. You can do it too!!”

10 / 10
Was this helpful?YesNo
Anonymous May 16, 2012

“I've taken sulfasalazine for four months (1000 MG twice per day). It took at least six weeks to become effective, but combined with Etodolac, an anti-inflammatory, I have had good success with controlling a mono-arthritic knee that had been diagnosed as rheumatoid arthritis after almost 20 years of problems, various surgeries, etc. I worry about side-effects, but the pain and extreme swelling is controlled after many years.”

7 / 10
Was this helpful?YesNo
Kjay · Taken for 6 months to 1 year July 8, 2019

“Diagnosed with RA 2013. Managed on hydroxy & kenalog injections until last year when wrists, neck & knees were in constant pain. Started on sulphasalazine last September - kenalog injection initially reduced pain & swelling until it kicked in & apart from a couple of blood issues sulfasalazine has been great. No daily side effects at all but when reached 4 daily my neutrophils decreased to an unacceptable low. I’m now settled on 3/day rather than 4 & it’s seems to be working for me.”

8 / 10
Was this helpful?YesNo
Cbshah January 22, 2018

“I’ve been on sulfasalazine for RA for about 10 weeks. I increased the dose gradually over 3 weeks. Once I reached the full dose (2000 mg/day) I started noticing side effects. Mostly headaches/nausea. I decided to try to stick it out and I’m so glad I did. Eventually side effects went away as I adjusted to the med. Over the past week I’ve felt better than I have in years! Still have joints that sore, but the symptoms I have are very mild compared to what they once were. Hoping this continues to improve over the next few months.”

9 / 10
Was this helpful?YesNo
Inflame62 · Taken for 2 to 5 years April 16, 2020

“Been on this sulfasalazine for RA for 4 years have now and for last 6 months sharp cramping pain in stomach right of navel. I don’t if anyone else has had this problem plus pain under left rib. Seriously thinking of packing it in joints no improvement either also dry itchy upper feet. Also been taking it without folic acid a which is advisable apparently , but which I didn’t know about.This drug can cause folate deficiency and vit-b12 deficiency too.Horrible drug.”

3 / 10
Was this helpful?YesNo
Susanne35Cat July 6, 2011

Sulfazine (sulfasalazine): “I have Rheumatoid Arthritis and have been using Sulfasalazine for the last 4 years as an "add-on" to methotrexate. I take the maximum dose, but must confess that I can only see a minimal reduction of pain using this medicine. ”

5 / 10
Was this helpful?YesNo
Moggie 1 February 26, 2015

“My reaction was unusual! After the second week I began to get daily severe headaches and raised temperature, after the third week my temperature was quite high, still severe headaches, doctor thought it was an infection, blood tests showed extremely high CRP, ESR and raised liver enzymes, also extremely low blood pressure. I was taken off sulfasalazine and treated with antibiotics, improved quickly, recommenced medicine and had exactly the same reaction within aweek!”

1 / 10
Was this helpful?YesNo
karenbuff April 11, 2010

Sulfazine (sulfasalazine): “I have had a small improvement with sulfazine, but unfortunately I started having severe ringing in the ears after 6 months, also it gave me pain in my achilles tendon and calves at night. Keep in mind that I had the pain side effect also with cholestrol medications, but not the ringing in the ears.”

4 / 10
Was this helpful?YesNo
mygoldens April 25, 2016

“I have only been on this med for 4 months. It has helped with my stiffness. My body would become so stiff, felt like I had pre death rigormortis... especially after sitting for any length of time. Getting up from a sitting position was extremely painful and awkward. My only complaint about the med is that it is to large for me to swallow. I take 3 per day, and I am fearful that I will choke on them. They scrape my throat and esophagus when I take them. Wish they would change the shape and coat them to make them easier to take.”

8 / 10
Was this helpful?YesNo
jonnyohio · Taken for 1 to 6 months January 29, 2019

“Was diagnosed with RA in July 2018, started on Plaquenil a couple weeks after, then in December 2018 they started me on the sulfasalazine. I was very gassy when starting out. It took me 6 weeks to go from 500mg per day to 2000mg. My symptoms were pretty severe in July 2018, and it took about 4 months for Plaquenil to do anything. At about 6 weeks on sulfasalazine, I started getting improvements. I'm now at 9 weeks and I went all day and barely had any joint pain. The only thing that sucks is it seems to be making my GERD symptoms a little worse at times still. I'm hoping that this will gradually decline in the next few weeks though. Other than that, I get a bit drowsy and seem to sleep longer on this. But so far I'm pretty happy with it.”

8 / 10
Was this helpful?YesNo
australiankitten June 9, 2016

“I have been on these meds for 6 weeks now. Started with one pill a day, then increased weekly to four pills a day. It has greatly helped with my pain. I'm sleeping better at night and especially within the last week, have been able to go about life almost how I did prediagnosis. So for that part - I would recommend giving it a go. As for side effects, I've been fortunate enough to not experience any type of stomach upset or headaches or anything like that. I have however been losing alot of hair. I can run my hand through very lightly, no tugging whatsoever, and end up with about 20 strands. I can run my hand through continually like this and the same thing happens. No pain from pulling, just falling out :( Choosing to tough it out for now”

6 / 10
Was this helpful?YesNo
painfree plz · Taken for 1 to 6 months February 6, 2019

“I thought my head was going to explode. I started at 2 a day then went up to 4 a day. I been on it for about a month, now. But not taking it anymore, been unable to go to work for 3 days now,,,,run run - do not take - it is too much,”

1 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Rheumatoid Arthritis

IBM Watson Micromedex

Symptom checker

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference