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Rituxan Side Effects

Generic name: rituximab

Medically reviewed by Drugs.com. Last updated on Mar 16, 2025.

Note: This document provides detailed information about Rituxan Side Effects associated with rituximab. Some dosage forms listed on this page may not apply specifically to the brand name Rituxan.

Applies to rituximab: intravenous solution.

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Fatal infusion-related reactions may occur within 24 hours of rituximab infusion; approximately 80% of fatal reactions occurred with the first infusion.

Monitor patients and discontinue rituximab infusion after severe reactions.

Severe and potentially fatal mucocutaneous reactions can occur.

Reactivation of hepatitis B virus (HBV) may occur; in some cases, it results in fulminant hepatitis, hepatic failure, or death.

Screen patients for HBV infection prior to treatment.

Progressive multifocal leukoencephalopathy (PML) and death can also occur.

Intravenous route (solution)

Warning: Fatal Infusion Reactions, Severe Mucocutaneous Reactions, Hepatitis B Virus Reactivation, and Progressive Multifocal Leukoencephalopathy. Fatal infusion-related reactions within 24 hours of rituximab infusion; approximately 80% of fatal infusion reactions occurred with first infusion.

Monitor patients and discontinue rituximab-pvvr infusion for severe reactions.Severe mucocutaneous reactions, some with fatal outcomesHepatitis B virus (HBV) reactivation, in some cases resulting in fulminant hepatitis, hepatic failure, and deathProgressive multifocal leukoencephalopathy (PML) resulting in death

Intravenous route (solution)

Fatal infusion reactions may occur within 24 hours of rituximab infusion; approximately 80% of fatal reactions occurred with the first infusion.

Monitor patients and discontinue rituximab-abbs infusion for severe reactions.

Severe and potentially fatal mucocutaneous reactions can occur.

Reactivation of hepatitis B virus (HBV) may occur with some cases resulting in fulminant hepatitis, hepatic failure, or death.

Screen patients for HBV infection prior to treatment.

Progressive multifocal leukoencephalopathy (PML), including fatal PML, can also occur.

Intravenous route (solution)

Warning: Fatal Infusion-Related Reactions, Severe Mucocutaneous Reactions, Hepatitis B Virus Reactivation, and Progressive Multifocal Leukoencephalopathy. Fatal infusion-related reactions within 24 hours of rituximab infusion; approximately 80% of fatal reactions occurred with first infusion.

Monitor patients and discontinue rituximab-arrx infusion for severe reactions.Severe mucocutaneous reactions, some with fatal outcomes.Hepatitis B virus (HBV) reactivation, in some cases resulting in fulminant hepatitis, hepatic failure, and death.Progressive multifocal leukoencephalopathy (PML) resulting in death.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before giving you this medicine. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 12 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

This medicine can cause a hepatitis B infection to come back. Check with your doctor right away if you have any symptoms of liver problems, including skin and eyes turning yellow, dark brown-colored urine, right-sided abdominal or stomach pain, fever, or severe tiredness.

Serious skin and mouth reactions (eg, paraneoplastic pemphigus, Stevens-Johnson syndrome, lichenoid dermatitis, vesiculobullous dermatitis, and toxic epidermal necrolysis) can occur during treatment with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness while you are receiving this medicine.

This medicine may cause a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML). The risk for getting this infection is higher if you have rheumatoid arthritis. Talk to your doctor about the benefits of receiving this medicine and the risk for this infection. Check with your doctor right away if you have vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, and weakness in the legs.

This medicine may cause a serious type of reaction called tumor lysis syndrome (TLS). Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.

This medicine may increase your risk of developing infections (eg, viral, bacterial, or fungal) during or after treatment with this medicine. Avoid being near people who are sick or have infections while you are using this medicine. Wash your hands often. Tell your doctor if you have lupus or if you have any kind of infection before you start using this medicine. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.

Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, flu-like symptoms (eg, runny or stuffy nose, headache, blurred vision, or feeling generally ill), painful or difficult urination, or sores, ulcers, or white spots in the mouth or on the lips. These may be signs that you have an infection.

While you are being treated with rituximab (the active ingredient contained in Rituxan) and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. You may receive non live vaccines at least 4 weeks before starting treatment with this medicine. Rituximab may lower your body's resistance, and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not get live vaccines (eg, nasal flu virus vaccine). Try to avoid persons who have taken live vaccines. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should wear a protective face mask that covers the nose and mouth.

This medicine may cause heart and heart rhythm problems (eg, heart attack, arrhythmia, cardiogenic shock). Check with your doctor if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, dizziness, fainting, fast, slow, or irregular heartbeat, cool, sweaty skin, or trouble breathing.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

This medicine may cause serious stomach and bowel problems, especially when used with other cancer medicines. Check with your doctor right away if you start having stomach pain while being treated with this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Rituxan

Along with its needed effects, rituximab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking rituximab:

More common side effects

  • back pain
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • blurred vision
  • body aches or pain
  • burning or stinging of the skin
  • chest pain or tightness
  • chills
  • confusion
  • cough
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • ear congestion
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • hives or welts, itching, rash
  • increased hunger
  • increased thirst
  • increased urination
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • lower back or side pain
  • nausea
  • nervousness
  • noisy breathing
  • pain or tenderness around the eyes and cheekbones
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • seizures
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain
  • stuffy or runny nose
  • sweating
  • swelling of the tongue or throat
  • swollen glands
  • tingling of the hands or feet
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Less common side effects

  • blistering, peeling, or loosening of the skin
  • blisters on the trunk, scalp, or other areas
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
  • decreased frequency and amount of urine
  • diarrhea
  • difficulty with moving
  • discouragement
  • feeling sad or empty
  • irregular heartbeat
  • irritability
  • joint or muscle pain
  • loss of appetite
  • loss of interest or pleasure
  • lump or growth on the skin
  • muscle cramp, pain, or stiffness
  • numbness or tingling in the hands, feet, or lips
  • painful blisters on the trunk of the body
  • pain or redness at the injection site
  • pain, swelling, or redness in the joints
  • pounding or irregular heartbeat or pulse
  • red skin lesions, often with a purple center
  • red, itchy lining of the eye
  • redness of the face, neck, arms, and occasionally, upper chest
  • stabbing pain
  • trouble concentrating
  • trouble sleeping

Incidence not known

  • blue-yellow color blindness
  • blurred vision or other change in vision
  • burning or stinging of the skin
  • decreased vision
  • dilated neck veins
  • dry cough
  • extreme tiredness or weakness
  • eye pain, tearing
  • feeling of discomfort, illness, or weakness
  • irregular breathing
  • nosebleed
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • sensitivity of the eye to light
  • severe stomach pain
  • severe vomiting, sometimes with blood
  • sores, welts, or blisters
  • stomach cramps
  • swelling, stiffness, redness, or warmth around many joints
  • swollen lymph glands
  • vision loss

Other side effects of Rituxan

Some side effects of rituximab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • fear
  • lack or loss of strength
  • loss or thinning of the hair
  • night sweats
  • throat irritation

Less common side effects

  • agitation or anxiety
  • bone pain
  • burning, dry, or itching eyes
  • change in taste
  • discharge, excessive tearing
  • dry eyes
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • heartburn
  • increase in body movements
  • lightheadedness
  • muscle tension
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sensation of spinning
  • sleepiness
  • swelling of the stomach

For healthcare professionals

Applies to rituximab: intravenous solution.

Cardiovascular adverse events

Dermatologic

Gastrointestinal

Hematologic

Hepatic

Hypersensitivity

Immunologic

Local

Metabolic

Musculoskeletal

Nervous system

Ocular

Oncologic

Other

Psychiatric

Renal

Respiratory

See also:

References

1. (2001) "Product Information. Rituxan (rituximab)." Genentech

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Pharmaceutical Society of Australia (2006) APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp

Frequently asked questions

Further information

Rituxan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.