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Breyanzi

Generic Name: lisocabtagene maraleucel
Dosage Form: suspension for intravenous infusion

Medically reviewed by Judith Stewart, BPharm. Last updated on Feb 9, 2021.

What is Breyanzi?

Breyanzi is for the treatment of large B-cell lymphoma in patients when at least 2 previous treatments have not worked or have stopped working. Breyanzi is a medicine made from your own white blood cells; the cells are genetically modified to recognize and attack your lymphoma cells.

Warnings

Breyanzi may cause side effects that are life-threatening and can lead to death.
Call your healthcare provider or get emergency help right away if you get any of the following:

  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • severe nausea, vomiting, diarrhea
  • fast or irregular heartbeat
  • dizziness/lightheadedness
  • severe fatigue or weakness

It is important that you tell your healthcare providers that you have received Breyanzi and to show them your Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

How will I receive Breyanzi?

  • Breyanzi is made from your own white blood cells, so your blood will be collected by a process called "leukapheresis".
  • It takes about 3-4 weeks from the time your cells are received at the manufacturing site and are available to be shipped back to your healthcare provider, but the time may vary.
  • Before you get Breyanzi, you will get 3 days of chemotherapy to prepare your body.
  • When your Breyanzi is ready, your healthcare provider will give it to you through a catheter (tube) placed into your vein (intravenous infusion). Breyanzi is given as infusions of 2 different cell types.
    • You will receive infusions of one cell type, immediately followed by the other cell type.
    • The time for infusion will vary, but will usually be less than 15 minutes for each of the 2 cell types.
  • During the first week, you will be monitored daily by the facility where you received your treatment.
  • You should plan to stay close to this location for at least 4 weeks after getting Breyanzi. Your healthcare provider will check to see that your treatment is working and help you with any side effects that may occur.
  • You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving Breyanzi?

  • Do not drive, operate heavy machinery, or do other activities that could be dangerous if you are not mentally alert, for at least 8 weeks after you get Breyanzi. This is because the treatment can cause temporary memory and coordination problems, including sleepiness, confusion, dizziness, and seizures.
  • Do not donate blood, organs, tissues, or cells for transplantation.

Breyanzi side effects

The most common side effects are:

  • fatigue
  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • difficulty speaking or slurred speech
  • severe nausea, vomiting, diarrhea
  • headache
  • dizziness/lightheadedness
  • fast or irregular heartbeat
  • swelling

Breyanzi can increase the risk of life-threatening infections that may lead to death.
Tell your healthcare provider right away if you develop fever, chills, or any signs or symptoms of an infection.

Breyanzi can lower one or more types of your blood cells (red blood cells, white blood cells, or platelets). After treatment, your healthcare provider will test your blood to check for this. Tell your healthcare provider right away if you get a fever, are feeling tired, or have bruising or bleeding.

Having Breyanzi in your blood may cause a false-positive HIV test result by some commercial tests.

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of Breyanzi

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider for information that is written for health professionals.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.