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Rituxan

Generic Name: rituximab (ri TUX i mab)
Brand Names: Rituxan

Medically reviewed on Oct 12, 2018

What is Rituxan?

See also: Kevzara

Rituxan (rituximab) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Rituxan injection is a prescription medicine used alone or in combination with other medicines to treat the following conditions in adults:

It is not known if Rituxan is safe and effective in children.

Important Information

Rituxan may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Tell your doctor if you have ever had hepatitis B. Rituxan can cause this condition to come back or get worse.

Severe skin problems can also occur during treatment with Rituxan. Call your doctor if you have painful skin or mouth sores, or a severe skin rash with blistering, peeling, or pus.

Some side effects may occur during the injection or within 24 hours afterward. Tell your caregiver right away if you feel dizzy, weak, light-headed, short of breath, or if you have chest pain, wheezing, sudden cough, or pounding heartbeats or fluttering in your chest.

Before taking this medicine

Rituxan may cause a serious brain infection that can lead to disability or death. This infection may be more likely if have used an immunosuppressant drug in the past, or if you have received Rituxan with a stem cell transplant.

You should not be treated with Rituxan if you are allergic to rituximab.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • liver disease or hepatitis (or if you are a carrier of hepatitis B);

  • kidney disease;

  • lung disease or a breathing disorder;

  • a weak immune system (caused by disease or by using certain medicines);

  • an active infection, including herpes, shingles, cytomegalovirus, chickenpox, parvovirus, West Nile virus, or hepatitis B or C;

  • heart disease, angina (chest pain), or heart rhythm disorder; or

  • if you have used rituximab in the past.

Do not use Rituxan if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 12 months after your last dose.

It is not safe to breast-feed a baby while you are using this medicine. Also do not breast-feed for at least 6 months after your last dose.

How is Rituxan given?

Rituxan is given as an infusion into a vein. A healthcare provider will give you this injection.

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Rituxan.

Rituxan is not given daily. Your schedule will depend on the condition being treated. Follow your doctor's dosing instructions very carefully.

Before each injection, you may be given other medications to prevent certain side effects of rituximab.

You will need frequent medical tests.

If you've ever had hepatitis B, using Rituxan can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

If you need surgery, tell the surgeon ahead of time that you are using this medicine.

What happens if I miss a dose?

Call your doctor if you miss an appointment for your Rituxan injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Rituxan?

Do not receive a "live" vaccine while using Rituxan, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Rituxan side effects

Get emergency medical help if you have signs of an allergic reaction to Rituxan: hives; chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection (or within 24 hours afterward). Tell your caregiver right away if you feel itchy, dizzy, weak, light-headed, short of breath, or if you have chest pain, wheezing, sudden cough, or pounding heartbeats or fluttering in your chest.

Rituximab may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have any of the following symptoms (which may start gradually and get worse quickly):

  • confusion, memory problems, or other changes in your mental state;

  • weakness on one side of your body;

  • vision changes; or

  • problems with speech or walking.

Call your doctor at once if you have any of these other side effects, even if they occur several months after you receive Rituxan, or after your treatment ends.

  • fever, chills, cold or flu symptoms, cough, sore throat, headache, earache;

  • pain or burning when you urinate;

  • painful skin or mouth sores, or a severe skin rash with blistering, peeling, or pus;

  • redness, warmth, or swelling of the skin;

  • severe stomach pain, vomiting, constipation, bloody or tarry stools;

  • chest pain, irregular heartbeats;

  • dark urine, or jaundice (yellowing of the skin or eyes);

  • low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or

  • signs of tumor cell breakdown - confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Common Rituxan side effects may include:

  • fever, chills, body aches, anemia, infections;

  • nausea, diarrhea;

  • swelling in your hands or feet;

  • feeling tired;

  • joint pain, muscle spasms; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rituxan?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with rituximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rituxan only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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