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Generic name: loncastuximab tesirine-lpyl
Dosage form:   lyophilized powder for injection, for intravenous use
Drug class: Miscellaneous antineoplastics

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 22, 2023.

What is Zynlonta?

Zynlonta is a prescription medicine used to treat adults with certain types of large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory), who have already received two or more treatments for their cancer.

It is not known if this medicine is safe and effective in children.

Before receiving Zynlonta

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

Males with female partners who can become pregnant:

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get new medicine.

How do I use Zynlonta?

What should I avoid while receiving Zynlonta?

Avoid or limit your exposure to sunlight, including sunlight through glass, such as buildings or vehicle windows and artificial sunlight such as sunlamps or tanning beds. Exposure to sunlight during treatment can cause skin reaction or rash. Use sun protection measures such as sunscreen and wear loose fitting clothes that cover your skin while out in sunlight.

Zynlonta side effects

Zynlonta may cause serious side effects, including:

The most common side effects include:

Zynlonta may cause fertility problems in males which may affect your ability to father children. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1 800-FDA-1088.

What other drugs will affect Zynlonta?

Other drugs may interact with loncastuximab tesirine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

General information about the safe and effective use of Zynlonta.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information that is written for healthcare professionals.

What are the ingredients in Zynlonta?

Active ingredient: loncastuximab tesirine-lpyl
Inactive ingredients: L-histidine, L-histidine monohydrochloride, polysorbate 20, and sucrose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.