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Loncastuximab tesirine

Generic name: loncastuximab tesirine [ LON-kas-TUX-i-mab-TES-ir-een ]
Brand name: Zynlonta
Dosage form: intravenous injection (lpyl 10 mg)
Drug class: Miscellaneous antineoplastics

Medically reviewed by on Jun 1, 2023. Written by Cerner Multum.

What is loncastuximab tesirine?

Loncastuximab tesirine is used to treat large B-cell lymphoma after at least two other cancer treatments did not work or have stopped working.

Loncastuximab tesirine may also be used for purposes not listed in this medication guide.

Loncastuximab tesirine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Loncastuximab tesirine may cause serious side effects. Call your doctor at once if you have:

Common side effects of loncastuximab tesirine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms (cough, tiredness, weakness, body aches), headache, trouble breathing, or skin wounds with pain, redness, warmth, or swelling.

Before taking this medicine

Tell your doctor if you have ever had:

Loncastuximab tesirine can harm an unborn baby if the mother or the father is using loncastuximab tesirine.

It may be harder for a man to get a woman pregnant while using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

How should I use loncastuximab tesirine?

Loncastuximab tesirine is injected into a vein by a healthcare provider, usually once every 3 weeks.

You may be given other medications to help prevent serious side effects. Keep using these medicines for as long as your doctor has prescribed.

You may get infections more easily, even serious or fatal infections. You will need frequent medical tests, and further doses may be delayed based on the results.

Loncastuximab tesirine dosing information

Usual Adult Dose for Lymphoma:

0.15 mg/kg IV over 30 minutes on Day 1 of each cycle (every 3 weeks) for 2 cycles, then 0.075 mg/kg IV over 30 minutes every 3 weeks for subsequent cycles

-Premedicate with dexamethasone 4 mg orally or IV 2 times a day for 3 days beginning the day before this drug.
-If dexamethasone administration does not begin the day before this drug, dexamethasone should begin at least 2 hours prior to administration of this drug.

Use: For the treatment of adult patients with relapsed or refractory large B-cell lymphoma after 2 or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your loncastuximab tesirine injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while using loncastuximab tesirine?

Loncastuximab tesirine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect loncastuximab tesirine?

Other drugs may affect loncastuximab tesirine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.