Loncastuximab Tesirine Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 13, 2024.

Applies to loncastuximab tesirine: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Women should use an effective form of birth control to avoid pregnancy during treatment and for at least 9 months after the last dose. Men should use an effective form of birth control to avoid pregnancy in sexual partners during treatment and for at least 6 months after the last dose. If you think a pregnancy has occurred with the medicine, tell your doctor right away.

Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

This medicine may cause fluid retention (eg, pleural effusion, pericardial effusion). Check with your doctor right away if you have chest pain or discomfort, swelling in the stomach and bloating, or trouble breathing while using this medicine.

This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

Check with your doctor right away if you have an increased sensitivity of the skin to sunlight, itching, rash with flat lesions or small raised lesions on the skin, redness or other discoloration of the skin, severe sunburn, or unusually warm skin. These may be symptoms of serious skin reactions (eg, photosensitivity reaction, exfoliative rash, maculopapular rash, and erythema). Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Serious side effects

Along with its needed effects, loncastuximab tesirine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking loncastuximab tesirine:

Other side effects

Some side effects of loncastuximab tesirine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to loncastuximab tesirine: intravenous injection.

General adverse events

The most common (greater than 20%) adverse reactions, including laboratory abnormalities, were thrombocytopenia, increased gamma-glutamyltransferase, neutropenia, anemia, hyperglycemia, transaminase elevation, fatigue, hypoalbuminemia, rash, edema, nausea, and musculoskeletal pain.^[Ref]

Immunologic

• Common (1% to 10%): Sepsis/escherichia sepsis/septic shock
• Frequency not reported: Immunogenicity^[Ref]

Local

• Uncommon (0.1% to 1%): Infusion site extravasation^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (e.g., musculoskeletal pain, musculoskeletal chest pain, musculoskeletal discomfort, back pain, limb discomfort, myalgia, neck pain, non-cardiac chest pain, pain in extremity) (23%)^[Ref]

Metabolic

• Very common (10% or more): Glucose increased (48%), edema (e.g., edema, face edema, generalized edema, peripheral edema, ascites, fluid overload, peripheral swelling, swelling, swelling face) (28%), anorexia (15%)^[Ref]

Hepatic

• Very common (10% or more): AST increased (37%), ALT increased (34%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea/dyspnea exertional (13%), pleural effusion (10%), upper respiratory tract infection (e.g., upper respiratory tract infection, upper respiratory tract congestion, nasopharyngitis, rhinitis, rhinovirus infection, sinusitis (10%)
• Common (1% to 10%): Pleural effusion (Grade 3), pneumonia/pneumonitis, pleuritis^[Ref]

Other

• Very common (10% or more): Fatigue/asthenia/lethargy (38%)^[Ref]

Hematologic

• Very common (10% or more): Platelets decreased (58%), neutrophils decreased (52%), hemoglobin decreased (51%), albumin decreased (37%), neutropenia (Grade 3 or 4) (32%), thrombocytopenia (20%), anemia (12%)
• Common (1% to 10%): Febrile neutropenia^[Ref]

Cardiovascular

• Common (1% to 10%): Pericarditis^[Ref]

Dermatologic

• Very common (10% or more): Rash (e.g., rash erythematous, rash maculopapular, rash pruritic, rash pustular, erythema, generalized erythema, dermatitis, dermatitis acneiform, dermatitis bullous, dermatitis exfoliative generalized, palmar-plantar erythrodysesthesia syndrome) (30%), pruritus (12%), photosensitivity reaction (10%)
• Common (1% to 10%): Hyperpigmentation, dermatitis^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (23%), diarrhea (17%), abdominal pain (e.g., abdominal pain, abdominal discomfort, abdominal pain lower, abdominal pain upper) (14%), vomiting (13%), constipation (12%)
• Common (1% to 10%): Pericardial effusion^[Ref]

See also:

Further information

Loncastuximab tesirine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer