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Methotrexate Drug Interactions

A total of 578 drugs are known to interact with methotrexate.

  • 121 major drug interactions
  • 441 moderate drug interactions
  • 16 minor drug interactions

Show all medications in the database that may interact with methotrexate.

Check for interactions

Type in a drug name to check for interactions with methotrexate.

Most frequently checked interactions

View interaction reports for methotrexate and the medicines listed below.

Methotrexate alcohol/food interactions

There are 3 alcohol/food interactions with methotrexate

Methotrexate disease interactions

There are 5 disease interactions with methotrexate which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.