Methotrexate Drug Interactions
Currently displaying a list of 724 drugs known to interact with methotrexate.
- 145 major drug interactions
- 564 moderate drug interactions
- 15 minor drug interactions
Medications known to interact with methotrexate
Note: Showing generic names only.
A
- abacavir
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acarbose
- acetaminophen
- acitretin
- adagrasib
- adalimumab
- adefovir
- adenovirus vaccine
- ado-trastuzumab emtansine
- afatinib
- aldesleukin
- alectinib
- alefacept
- alemtuzumab
- allogeneic processed thymus tissue
- allopurinol
- alpelisib
- ambrisentan
- aminolevulinic acid
- aminolevulinic acid topical
- aminosalicylic acid
- amiodarone
- amoxicillin
- amphotericin b
- amphotericin b cholesteryl sulfate
- amphotericin b lipid complex
- amphotericin b liposomal
- ampicillin
- anakinra
- anthrax vaccine adsorbed
- apalutamide
- aprocitentan
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atezolizumab
- atomoxetine
- atorvastatin
- atovaquone
- atrasentan
- avacopan
- avelumab
- axitinib
- azithromycin
B
- bacampicillin
- bacitracin
- balsalazide
- baricitinib
- bcg
- bcg vaccine
- bedaquiline
- belinostat
- belumosudil
- bempedoic acid
- benazepril
- bendamustine
- bendroflumethiazide
- benzthiazide
- betamethasone
- bexarotene
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- binimetinib
- bismuth subsalicylate
- black cohosh
- bleomycin
- blinatumomab
- bortezomib
- bosentan
- bosutinib
- botulism immune globulin
- brentuximab
- brewer's yeast
- brigatinib
- bromfenac
- budesonide
- bupropion
- busulfan
C
- cabazitaxel
- caffeine
- calaspargase pegol
- canakinumab
- candida albicans extract
- cannabidiol
- capmatinib
- capreomycin
- captopril
- carbamazepine
- carbenicillin
- carboplatin
- carfilzomib
- carmustine
- caspofungin
- ceftazidime
- ceftobiprole medocaril
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cerivastatin
- certolizumab
- chaparral
- charcoal
- chenodiol
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chlorambucil
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chloroquine
- chlorothiazide
- chlorthalidone
- chlorzoxazone
- cholera vaccine
- cholera vaccine, live
- choline salicylate
- cidofovir
- cinoxacin
- ciprofloxacin
- cisplatin
- cladribine
- clarithromycin
- clavulanate
- clofarabine
- clotrimazole
- cloxacillin
- clozapine
- cobimetinib
- coccidioidin skin test
- colistimethate
- comfrey
- corticorelin
- corticotropin
- cortisone
- cosibelimab
- cosyntropin
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- cyclosporine
- cytarabine
- cytarabine liposomal
- cytomegalovirus immune globulin
D
- dacarbazine
- daclizumab
- danazol
- danicopan
- dantrolene
- daprodustat
- dapsone topical
- darolutamide
- darunavir
- daunorubicin
- daunorubicin liposomal
- deferasirox
- deferiprone
- dehydroepiandrosterone
- delafloxacin
- delandistrogene moxeparvovec
- demeclocycline
- dengue vaccine
- denosumab
- deucravacitinib
- dexamethasone
- dexlansoprazole
- diatrizoate
- diclofenac
- diclofenac topical
- dicloxacillin
- didanosine
- diflunisal
- digoxin
- dimethyl fumarate
- diroximel fumarate
- disulfiram
- divalproex sodium
- docetaxel
- dolutegravir
- dostarlimab
- doxorubicin
- doxorubicin liposomal
- doxycycline
- dronedarone
- duloxetine
- durvalumab
- duvelisib
E
- efalizumab
- efavirenz
- efbemalenograstim alfa
- eflapegrastim
- eflornithine
- elacestrant
- elagolix
- elotuzumab
- elranatamab
- eltrombopag
- eluxadoline
- emtricitabine
- enalapril
- enalaprilat
- enasidenib
- encorafenib
- enoxacin
- entecavir
- entrectinib
- epirubicin
- eravacycline
- erlotinib
- erythromycin
- esomeprazole
- etanercept
- ethambutol
- ethanol
- ethionamide
- ethotoin
- etidronate
- etodolac
- etoposide
- etranacogene dezaparvovec
- etrasimod
- etretinate
- everolimus
- exenatide
F
- febuxostat
- fedratinib
- felbamate
- fenofibrate
- fenofibric acid
- fenoprofen
- fexinidazole
- fezolinetant
- fidanacogene elaparvovec
- filgrastim
- fingolimod
- fitusiran
- floxuridine
- fluconazole
- flucytosine
- fludarabine
- fludrocortisone
- fluorouracil
- fluoxymesterone
- flurbiprofen
- flutamide
- fluvastatin
- folic acid
- fosinopril
- fosphenytoin
- fostamatinib
- fostemsavir
- fruquintinib
- futibatinib
G
- gadobenate dimeglumine
- gallium citrate ga-67
- ganciclovir
- gatifloxacin
- gefitinib
- gemcitabine
- gemfibrozil
- gemifloxacin
- gemtuzumab
- gilteritinib
- givosiran
- glasdegib
- golimumab
- grepafloxacin
H
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- haloperidol
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- histoplasmin
- human papillomavirus vaccine
- hydrochlorothiazide
- hydrocortisone
- hydroflumethiazide
- hydroxychloroquine
- hydroxyurea
I
- ibandronate
- ibritumomab
- ibuprofen
- idarubicin
- idelalisib
- ifosfamide
- imatinib
- immune globulin intravenous
- immune globulin intravenous and subcutaneous
- indapamide
- indomethacin
- infliximab
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- inotersen
- inotuzumab ozogamicin
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- iodamide
- iodipamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate
- ioversol
- ioxaglate
- ioxilan
- ipilimumab
- isatuximab
- isoniazid
- isotretinoin
- itraconazole
- ivacaftor
- ivosidenib
- ixazomib
J
K
L
- l-methylfolate
- labetalol
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lamivudine
- lamotrigine
- lansoprazole
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- leflunomide
- lenacapavir
- lenalidomide
- leniolisib
- lenvatinib
- leucovorin
- levetiracetam
- levofloxacin
- levoketoconazole
- levoleucovorin
- levomefolate calcium
- lisinopril
- lomefloxacin
- lomitapide
- lomustine
- loncastuximab tesirine
- lovastatin
- lurbinectedin
- lutetium lu 177 dotatate
- lyme disease vaccine
M
- macitentan
- magnesium salicylate
- maralixibat
- maraviroc
- maribavir
- measles virus vaccine
- meclofenamate
- mefenamic acid
- meloxicam
- melphalan
- melphalan flufenamide
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- mephenytoin
- mercaptopurine
- mesalamine
- metaxalone
- methicillin
- methimazole
- methoxsalen
- methoxyflurane
- methyclothiazide
- methyl aminolevulinate topical
- methyldopa
- methylprednisolone
- methyltestosterone
- metolazone
- metrizamide
- mezlocillin
- midostaurin
- milnacipran
- minocycline
- mipomersen
- mirikizumab
- mitomycin
- mitotane
- mitoxantrone
- mixed respiratory vaccine
- moexipril
- momelotinib
- monomethyl fumarate
- moxifloxacin
- multivitamin, prenatal
- mumps skin test antigen
- mumps virus vaccine
N
- nabumetone
- nadofaragene firadenovec
- nafcillin
- nalidixic acid
- naltrexone
- nandrolone
- naproxen
- natalizumab
- naxitamab
- nefazodone
- nelarabine
- neomycin
- neratinib
- nevirapine
- niacin
- niacinamide
- nicotinamide
- nilotinib
- nilutamide
- nintedanib
- niraparib
- nirogacestat
- nitazoxanide
- nitisinone
- nitrofurantoin
- nitrous oxide
- nivolumab
- norfloxacin
O
- ocrelizumab
- ofloxacin
- olaparib
- olsalazine
- olutasidenib
- omacetaxine
- omeprazole
- onasemnogene abeparvovec
- orlistat
- oseltamivir
- osimertinib
- oteseconazole
- oxacillin
- oxaliplatin
- oxandrolone
- oxaprozin
- oxymetholone
- oxytetracycline
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palifermin
- pamidronate
- panobinostat
- pantoprazole
- paromomycin
- pasireotide
- pazopanib
- pegaspargase
- pegfilgrastim
- peginterferon alfa-2a
- peginterferon alfa-2b
- peginterferon beta-1a
- pembrolizumab
- pemetrexed
- pemoline
- penicillin g benzathine
- penicillin g potassium
- penicillin g sodium
- penicillin v potassium
- pennyroyal
- perindopril
- pertussis, acellular
- pexidartinib
- phenazopyridine
- phenylbutazone
- phenytoin
- pioglitazone
- piperacillin
- pirfenidone
- piroxicam
- pirtobrutinib
- pitavastatin
- pivmecillinam
- plague vaccine
- plazomicin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- polatuzumab vedotin
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- polymyxin b
- polythiazide
- ponatinib
- ponesimod
- porfimer
- posaconazole
- potassium acetate
- potassium citrate
- pralatrexate
- pralsetinib
- pravastatin
- prednisolone
- prednisone
- pretomanid
- probenecid
- procaine penicillin
- procarbazine
- propylthiouracil
- pyrazinamide
- pyrimethamine
Q
R
- rabeprazole
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- radium 223 dichloride
- ramipril
- red yeast rice
- regorafenib
- remdesivir
- repotrectinib
- resmetirom
- respiratory syncytial virus immune globulin
- retifanlimab
- rho (d) immune globulin
- ribociclib
- rifampin
- rilonacept
- rilpivirine
- riluzole
- ripretinib
- ritlecitinib
- ritonavir
- rofecoxib
- roflumilast
- rolapitant
- ropeginterferon alfa-2b
- rosiglitazone
- rosuvastatin
- rotavirus vaccine
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- ruxolitinib
- ruxolitinib topical
S
- saccharomyces boulardii lyo
- safinamide
- salsalate
- samarium sm 153 lexidronam
- sapropterin
- sargramostim
- sarilumab
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- satralizumab
- selpercatinib
- selumetinib
- simvastatin
- siponimod
- sipuleucel-T
- sirolimus
- skin test antigens, multiple
- smallpox and mpox vaccine
- smallpox vaccine
- sodium acetate
- sodium bicarbonate
- sodium citrate
- sodium lactate
- sodium phosphate p32
- sodium salicylate
- sodium thiosalicylate
- sorafenib
- sotorasib
- sparfloxacin
- sparsentan
- stanozolol
- staphage lysate (spl)
- stavudine
- streptococcus salivarius
- streptozocin
- strontium-89 chloride
- sulfadiazine
- sulfadoxine
- sulfamethizole
- sulfamethoxazole
- sulfasalazine
- sulfisoxazole
- sulindac
- sunitinib
T
- tacrine
- tacrolimus
- tafamidis
- tafasitamab
- talimogene laherparepvec
- talquetamab
- tamoxifen
- tarlatamab
- tbo-filgrastim
- teclistamab
- tedizolid
- telavancin
- telbivudine
- telithromycin
- temozolomide
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terbinafine
- teriflunomide
- testosterone
- testosterone topical
- tetanus toxoid
- tetracycline
- thalidomide
- theophylline
- thioguanine
- thiotepa
- ticarcillin
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tipranavir
- tislelizumab
- tivozanib
- tizanidine
- tocilizumab
- tofacitinib
- tolcapone
- tolmetin
- tolvaptan
- topotecan
- toripalimab
- tovorafenib
- trabectedin
- trandolapril
- tremelimumab
- treosulfan
- tretinoin
- triamcinolone
- trichlormethiazide
- trichophyton skin test
- trimethoprim
- trimetrexate
- trofinetide
- troglitazone
- troleandomycin
- tromethamine
- trovafloxacin
- tuberculin purified protein derivative
- tucatinib
- typhoid vaccine, inactivated
- typhoid vaccine, live
U
V
- vadadustat
- valacyclovir
- valdecoxib
- valganciclovir
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vancomycin
- varicella virus vaccine
- vemurafenib
- verteporfin
- vimseltinib
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- vitamin e
- voclosporin
- vorasidenib
- voriconazole
W
Y
Z
- zafirlukast
- zalcitabine
- zidovudine
- zileuton
- zoledronic acid
- zoster vaccine live
- zoster vaccine, recombinant
Methotrexate alcohol/food interactions
There are 3 alcohol/food interactions with methotrexate.
Methotrexate disease interactions
There are 5 disease interactions with methotrexate which include:
Report options
QR code containing a link to this page
More about methotrexate
- methotrexate consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (337)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: antimetabolites
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Skyrizi
Skyrizi (risankizumab) is used to treat plaque psoriasis, psoriatic arthritis, ulcerative colitis ...
Reviews & ratings
Verzenio
Verzenio is used to treat early and advanced-stage hormone receptor-positive, HER2-negative breast ...
Reviews & ratings
Featured
Otezla
Otezla (apremilast) is used to treat plaque psoriasis, psoriatic arthritis, and oral ulcers ...
Reviews & ratings
Trodelvy
Trodelvy (sacituzumab govitecan) is a targeted therapy used to treat breast cancer (triple-negative ...
Reviews & ratings
Stelara
Stelara (ustekinumab) is used to treat Crohn's disease, ulcerative colitis, plaque psoriasis, and ...
Reviews & ratings
Enhertu
Enhertu is a treatment for breast cancer, stomach cancer, and non-small cell lung cancer with HER2 ...
Reviews & ratings
Taltz
Taltz (ixekizumab) is used to treat plaque psoriasis, psoriatic arthritis, and ankylosing ...
Reviews & ratings
Opdivo Qvantig
Opdivo Qvantig is used to treat adults with melanoma, non-small cell lung cancer, renal cell ...
Reviews & ratings
Rybrevant
Rybrevant is used to treat certain types of non-small cell lung cancer (NSCLC) in adults. It is ...
Reviews & ratings
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
