Methotrexate Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Methotrexate	Humira (adalimumab)	Hydroxychloroquine	Enter another drug to compare

Methotrexate

Humira (adalimumab)

Hydroxychloroquine

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Prescribed for Rheumatoid Arthritis, Lupus, Lichen Planopilaris, Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Sjogren's Syndrome, Undifferentiated Connective Tissue... View more

More about Methotrexate

More about Humira (adalimumab)

More about Hydroxychloroquine

Ratings & Reviews

Methotrexate has an average rating of 6.5 out of 10 from a total of 339 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 704 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

Hydroxychloroquine has an average rating of 6.4 out of 10 from a total of 356 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 29% reported a negative effect.

View all 339 reviews

View all 704 reviews

View all 356 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (14.7%)
Tiredness (13.9%)
Fatigue (11.8%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.6%)
Loss of appetite (5.0%)

View all Methotrexate side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Nausea (11.8%)
Rash (9.3%)
Pain (7.9%)
Fatigue (6.7%)
Headaches (6.7%)
Hair loss (5.6%)
Upset stomach (5.1%)

View all Hydroxychloroquine side effects

Drug Class

Generic Availability

Lower cost generic

N/A

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	20 each
Strength	2.5 mg
Per unit^*	$0.74
Cost^*	$14.88

View all Methotrexate prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,534.54
Cost^*	$7,069.07

View all Humira prices

Quantity	50 each
Strength	200 mg
Per unit^*	$0.40
Cost^*	$19.90

View all Hydroxychloroquine prices

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Dosage Forms

Injectable powder for injection
Injectable solution
Oral tablet

Subcutaneous kit

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

15 hours

480 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 733 drugs are known to interact with Methotrexate:

148 major drug interactions (678 brand and generic names)
570 moderate drug interactions (2756 brand and generic names)
15 minor drug interactions (47 brand and generic names)

A total of 557 drugs are known to interact with Humira:

302 major drug interactions (877 brand and generic names)
246 moderate drug interactions (948 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 593 drugs are known to interact with Hydroxychloroquine:

227 major drug interactions (725 brand and generic names)
348 moderate drug interactions (1295 brand and generic names)
18 minor drug interactions (54 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

You may want to limit your consumption of grapefruit or grapefruit juice during treatment with... View more

Disease Interactions

First Approval Date

December 07, 1953

December 31, 2002

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Methotrexate uses

Humira uses

Hydroxychloroquine uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Methotrexate Alternatives Compared

See also:

Skyrizi

Verzenio

Otezla

Trodelvy

Stelara

Enhertu

Cosentyx

Humira

Ilumya

Taltz

Further information

Methotrexate Alternatives Compared

See also:

Further information

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