Methotrexate Alternatives Compared
| Methotrexate | Enbrel | Humira |
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| Methotrexate | Enbrel etanercept | Humira adalimumab |
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Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more |
Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more |
Choose a suggestion below Rheumatoid Arthritis
Juvenile Idiopathic Arthritis
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| More about Methotrexate | More about Enbrel (etanercept) | More about Humira (adalimumab) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Methotrexate has an average rating of 6.6 out of 10 from a total of 263 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
Enbrel has an average rating of 7.8 out of 10 from a total of 261 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. |
Humira has an average rating of 6.3 out of 10 from a total of 630 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 32% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Commonly reported side effects include: increased liver enzymes. See the full methotrexate side effects document. |
Common side effects include: infection, injection site reaction. See the full Enbrel side effects document. |
Common side effects include: upper respiratory tract infection, headache, injection site reaction, skin rash, antibody development, sinusitis, pain at injection site. See the full Humira side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all methotrexate prices |
View all Enbrel prices |
View all Humira prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | Other etanercept brands include: Erelzi, Eticovo | Other adalimumab brands include: Abrilada, Amjevita, Cyltezo, Hadlima, Hulio, Hyrimoz, Yusimry | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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15 hours |
300 hours |
480 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 625 drugs are known to interact with methotrexate:
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A total of 420 drugs are known to interact with Enbrel:
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A total of 420 drugs are known to interact with Humira:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 07, 1953 |
November 02, 1998 |
December 31, 2002 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.