Comparing Acitretin vs Methotrexate

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Acitretin	Methotrexate	Enter another drug to compare

Acitretin

Methotrexate

Prescription only

Prescribed for Psoriasis, Pityriasis rubra pilaris, Psoriatic Arthritis. Acitretin may also be used for purposes not listed in this medication guide.

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Acitretin

More about Methotrexate

Ratings & Reviews

Acitretin has an average rating of 5.4 out of 10 from a total of 36 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 33% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 336 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 36 reviews

View all 336 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Acitretin side effects

Nausea (14.6%)
Tiredness (14.0%)
Fatigue (11.3%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.4%)
Itching (4.5%)

View all Methotrexate side effects

Drug Class

Antipsoriatics

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 capsule
Strength	10 mg
Per unit^*	$9.69
Cost^*	$290.82

View all Acitretin prices

Quantity	20 each
Strength	2.5 mg
Per unit^*	$1.52
Cost^*	$30.31

View all Methotrexate prices

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Dosage Forms

Oral capsule

Injectable powder for injection
Injectable solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

96 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 67 drugs are known to interact with Acitretin:

30 major drug interactions (184 brand and generic names)
37 moderate drug interactions (97 brand and generic names)

A total of 723 drugs are known to interact with Methotrexate:

144 major drug interactions (666 brand and generic names)
564 moderate drug interactions (2732 brand and generic names)
15 minor drug interactions (47 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Take acitretin with food. Women must avoid all drinks, food, and medicines (including... View more

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

Disease Interactions

First Approval Date

October 28, 1996

December 07, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Methotrexate uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Acitretin vs Methotrexate

See also:

Stelara

Taltz

Skyrizi

Humira

Remicade

Inflectra

Amjevita

Hyrimoz

Avsola

Hadlima

Further information

Comparing Acitretin vs Methotrexate

See also:

Further information

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