Generic name: methotrexate (injection) [ meth-oh-TREX-ate ]
Brand names: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, RediTrex
Drug classes: Antimetabolites, Antipsoriatics, Antirheumatics, Other immunosuppressants
What is Rasuvo?
Rasuvo is also used alone to treat squamous cell carcinoma of the head and neck in adults.
Rasuvo may also be used for purposes not listed in this medication guide.
Rasuvo side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Rasuvo can cause serious or fatal side effects. Call your doctor at once if you have:
swollen lymph glands, night sweats, weight loss;
blisters or ulcers in your mouth, red or swollen gums, trouble swallowing, feeling very thirsty;
blood in your urine or stools, skin changes such as redness, warmth, swelling, or oozing;
low blood cell counts--fever, chills, bruising or bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
kidney problems--swelling, urinating less, feeling tired or short of breath;
Common side effects of Rasuvo may include:
low blood cell counts, fever, chills, tiredness, not feeling well;
headache, dizziness, cough, chest tightness, trouble breathing;
mouth sores, nausea, vomiting, stomach pain, diarrhea, runny or stuffy nose, sneezing, sore throat;
abnormal liver function tests; or
rash, hair loss, skin lesions, eyes being more sensitive to light.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Rasuvo should not be used during pregnancy to treat arthritis or psoriasis. This medicine injection is sometimes used to treat cancer during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant.
Rasuvo can cause serious or fatal side effects. Tell your doctor if you have diarrhea, mouth sores, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizures, or skin rash that spreads and causes blistering and peeling.
Before taking this medicine
You should not use Rasuvo if you are allergic to it.
Rasuvo should not be used to treat psoriasis or arthritis if you have:
a blood cell disorder, weak immune system; or
if you are pregnant or breastfeeding.
Rasuvo is sometimes used to treat cancer in people who have a condition listed above. Your doctor will decide if this treatment is right for you.
Tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
history of neurologic problems such as seizures;
any type of infection;
Make sure you are current on all vaccines before you start using Rasuvo. Tell your doctor if you recently received a vaccine or are scheduled for a booster dose.
Rasuvo can harm an unborn baby if the mother or the father is using Rasuvo. This medicine injection may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine. Tell your doctor if you are pregnant.
If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose.
If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
How is Rasuvo given?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Rasuvo is usually given once per week. Do not use this medicine more often than prescribed. Follow your doctor's dosing instructions very carefully.
Doses are based on body surface area (height and weight). Your dose may change if you gain or lose weight or if you are still growing.
Rasuvo is injected into a muscle, under the skin, or as an infusion into a vein. A healthcare provider will give you this injection and may teach you how to properly use the medication by yourself.
Rasuvo is injected in the stomach or thigh when used for psoriasis or arthritis. Do not inject within 2 inches of your navel (belly button), arms or other areas of the body, or areas where the skin is tender, bruised, red, hard, or has scars or stretch marks.
Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.
Do not reuse a needle or syringe, especially a single-use vial (bottle) or auto-injector. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws.
You will need frequent medical tests, and your next dose may be delayed based on the results.
Using Rasuvo may increase your risk of developing other cancers. Ask your doctor about this risk.
Follow all storage instructions provided with Rasuvo. Your pharmacist can provide more information about how to store this medicine.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Rasuvo, or if you forget to use the medicine at home.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methotrexate injection can be fatal.
What should I avoid while receiving Rasuvo?
Avoid drinking alcohol. It may increase your risk of liver damage.
Avoid receiving a "live" vaccine, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).
Avoid driving or hazardous activity until you know how Rasuvo will affect you. Your reactions could be impaired.
What other drugs will affect Rasuvo?
Tell your doctor about all your other medicines, especially:
This list is not complete and many other drugs may affect Rasuvo. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
You should take folic acid with methotrexate to help prevent a folate deficiency. Taking methotrexate can lower folate levels in your body and cause symptoms like extreme tiredness, mouth sores, confusion, pale color and weakness. Continue reading
To tell if methotrexate treatment is working for your rheumatoid arthritis your doctor will conduct regular blood tests and check-ups. You can also keep a track of your symptoms and looks for signs of improvement. Imaging tests, such as x-rays and musculoskeletal ultrasound (MSUS), may be used. Continue reading
Methotrexate was shown to cause a modest amount of weight gain over 6 months, in a study measuring weight changes in people with rheumatoid arthritis. Continue reading
Methotrexate can start working for rheumatoid arthritis within 3 to 6 weeks and symptoms continue to improve over 3 months. For other people it might take a few months before they notice any improvement in their rheumatoid arthritis symptoms. Continue reading
The different brands of methotrexate are Otrexup, Rasuvo, RediTrex, Trexall, and Xatmep. Continue reading
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More about Rasuvo (methotrexate)
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- Drug class: antimetabolites
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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