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User Reviews for Methotrexate

Also known as: Trexall, Rasuvo, Methotrexate LPF Sodium, Otrexup, Xatmep, RediTrex

Methotrexate has an average rating of 6.6 out of 10 from a total of 263 ratings on Drugs.com. 54% of reviewers reported a positive experience, while 24% reported a negative experience.

Condition Avg. Rating Reviews Compare
Rheumatoid Arthritis  
6.1
119 reviews 363 medications
Psoriasis  
8.0
86 reviews 318 medications
Psoriatic Arthritis  
6.0
30 reviews 78 medications
Ectopic Pregnancy  Off-label
5.3
7 reviews 1 medications
Eczema  Off-label
8.4
5 reviews 248 medications
Systemic Sclerosis  
8.5
4 reviews 11 medications
Dermatomyositis  
4.5
2 reviews 16 medications
Lymphoma  
1.5
2 reviews 64 medications
Juvenile Idiopathic Arthritis  
4.5
2 reviews 21 medications
Scleroderma  Off-label
1.0
2 reviews 9 medications
Gastric Cancer  Off-label
1.0
1 reviews 9 medications
Uveitis  Off-label
1 reviews 82 medications
Neoplastic Diseases  
7.0
1 reviews 3 medications
Cogan's Syndrome  Off-label
4.0
1 reviews 8 medications
Summary of Methotrexate reviews 6.6 263 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Methotrexate

Ducky · January 24, 2021

For Rheumatoid Arthritis: “Im on methotrexate 2.5 mg four pills 1x a week for around 5-6 years for RA. I feel good when taking this medicine correctly and on time. I had got sick from taking too many antibiotics for urinary track infection and was told to stop taking methotrexate because I had to take a powerful medicine to get my health back to normal and methotrexate may interact with that medicine. I went off for almost 1 1/2 months and RA kicked in bad, I was finished with the other medicine so I went back on methotrexate and the RA subsided. My point is, this medication really does help and never just go off it because you don’t feel any pain anymore, and you think you are cured believe me it’s the medication that’s working, you are not cured you’ll always have RA. I take mine once a week every Saturday and I feel great, if you skip a dose or 2 believe me ,you will know you skipped it, take it every week same day same time and you’ll feel as though you are cured , and I have had no side affects what so ever.”

10 / 10
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LagWag · Taken for 1 to 6 months · July 10, 2019

For Rheumatoid Arthritis: “This is a horrible drug. I took it once a week for 5 months, 12.5 mgs of awfulness. My hair started falling out in clumps, even with taking folic acid, the headaches and nausea are debilitating, along with the fatigue and general malaise that I experienced for 2-3 days after taking it. And it did not touch the flare ups or the pain I experienced from the RA. I have now completely changed my diet and my way of thinking to combat this disease. No gluten, no dairy, stress free as much as possible, and supplements like Nordic Fish Oils, Glucosamine and Chondroitin Sulfates and Turmeric help better than the Methotrexate did any day. I called this drug "Poison" the whole time I was taking it. Now I feel way better not taking and I know why, because it is a POISON. Stay far away from this drug and try life style changes before even considering this harmful drug.”

1 / 10
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rhirhi · Taken for 1 to 6 months · November 6, 2018

For Rheumatoid Arthritis: “I have been on methotrexate for a couple of months now, I’m not certain whether we just caught my disease at a good time but this medication has been 110% effective for me. I have had no symptoms since it kicked in (took a while), the most that will happen because of the medication is the day after I take it I will feel a little tired (was worse in the beginning), anyways please make sure you don’t read reviews and judge the medication from that. I nearly scared myself silly doing that, trust in your rheumatologist and follow the process. The medicine reacts with different people in different ways, I am definitely one of the lucky ones. I am 25 and methotrexate has given me back the lifestyle of a 25 year old!”

10 / 10
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killedmymom4-16-19 · Taken for 10 years or more · August 11, 2019

For Rheumatoid Arthritis: “My mom took methotrexate for over 15 years for R.A. She ended up methotrexate induced pulmonary fibrosis. The local hospital was treating her for pneumonia but that was not the case. Mom passed away at one of the nations top 10 hospitals from Acute Respiratory Distress Syndrome or Adult Respiratory Distress Syndrome. Death Certificate says she died from ARDS and RA. If you love yourself or your loved ones do not let them take this medication. DANGEROUS. She was 52 years old. I can't believe she gone and its all from a little yellow pill she took once a week. Low dose or not doesn't matter. IT CAN KILL YOU. AVOID. Read manufacturer black box warnings and find alternatives. The medicine didn't help much anyway if any.”

1 / 10
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Bexsy · Taken for 10 years or more · April 23, 2019

For Rheumatoid Arthritis: “My mum has DIED, she had RA in hands & knees. She was given THIS DRUG 13yrs ago. NO 1 told her/us its ALSO ANTI-CANCER drug, it destroys immune system, blood cells etc. YES, it relieves RA, but in 6 months mum went from 6ft tall 10 stone lady to a wheezing, weak, 6 stone shadow of her former self, mum died April 7 2019, she was home & arrested. At hospital 10pm, 1am they said she wouldn't survive? They did EVERY test, bloods/fluids/scans, NOTHING showed. She had lines in neck, drips everywhere, they treated for lots & hoped it worked. But at 5am advised us TURN OFF her life support. Drs were baffled. When they got GP info, & we mentioned methotraxate their faces dropped, they didn't blame meds solely, but they DID explain meds have knock on effect, & with prolonged use they can cause break downs in parts of body. More info should be available, to look out for signs & symptoms about this drug. Please keep getting checked out. Mum had blood tests monthly & nothing showed, she NEVER missed appointment. I'd stay clear of these meds”

1 / 10
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Badger · Taken for 1 to 6 months · March 2, 2020

For Psoriatic Arthritis: “Didn't want to take this drug methotrexate was anxious after reading various reviews and stuff on internet but Dr advised I needed it for my arthritis (psoriatic) also said that when I felt the results I'd wished I'd taken it before now. I also like a drink he said so do I have one just don't go daft. So far bloods are ok and he was right - wished I'd tried methotrexate ages ago. Before taking it I couldn't fasten laces, walk down stairs, hands were painful found it hard to do my job and ankle pain. What a difference this drug has made virtually pain free and now I am using stairs etc as normal it took me a little while to get used to it it and it does make me tired for a day or so after I take it but after that I feel great. I hope this helps someone.”

10 / 10
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Charis · Taken for 5 to 10 years · September 22, 2019

For Rheumatoid Arthritis: “I took this medication for about 5 yrs. Dr increased the dose to 8 pills a week. While I was on this I experienced bad headaches, I would bruise easily & badly if I bumped myself somewhere. I also developed lactose intolerance. which I was not until I took this. Overall, this medicine was making me worse & in addition to this, Dr. would give me cortisone shots for my joint pain that never went away. Shots were bad too. After 5 yrs, I stopped taking this medication with out the Dr.s knowledge. I am now taking pure supplements and still fighting RA but I am methotrexate free for 6 yrs.”

1 / 10
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Frequently asked questions

Yay · December 28, 2018

For Rheumatoid Arthritis: “I am 32 year old and a mother of two boys working full-time. I was on methotrexate for 2.5 years (10 mg per week oral). It did work and I had little side effects in the beginning. However, about 1-1.5 years in I became extremely fatigued and even depressed. I did not feel like myself. I read in other blogs that people had the same feelings as I did so I was glad I wasn’t alone. I was at a point in my journey where I could try and get off the medication . After only two weeks off the medication I felt amazing! Back to my old self! Both my husband and I were amazed. Fatigue gone. No longer going to bed at 7:30 pm. No more depression feelings. And thank goodness my RA symptoms have not reappeared. I do follow a strict dairy free, gluten free, almost pescatarian diet that I believe has a huge impact on RA. So if anyone is feeling this way please talk to your doctor and try a different approach to tackling your RA if you cannot live with the frustration of the fatigue and depression.”

5 / 10
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jFr123 · December 22, 2015

For Rheumatoid Arthritis: “Methotrexate has been a miracle for me. For the past 3 years experiencing extreme tiredness, no energy to do anything, thankful to get through a day's work. Tried every combination of vitamins the world has ever made without any results. Then over last one year severe inflammation of hands, could barely make a fist, difficulty using hands. Under rheumatologist advice used 2 other medications till placed on methotrexate with a dose of 5 pills per week. Have been on this dose past 8 months with great results. Have been walking, biking around from 2 to 4 miles frequently, mowing grass, doing property maintenance 6 to 8 hrs per day and still having energy to continue working on other things! Crossing fingers, THANKS METHOTREXATE!”

10 / 10
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Anonymous · Taken for 1 to 6 months · June 5, 2015

For Rheumatoid Arthritis: “I have been on this medication for about 2 months now. I was taking prednisone before but that wouldn't help much. After the second week of taking methotrexate I can honestly say I am pain free. I can actually enjoy doing all the stuff I used to do before being diagnosed with RA. Before starting this medication I would experience horrible pain in my shoulders, hands, fingers, hips and ankles. I would have a rough time getting through the day. This medication works wonderfully.”

10 / 10
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Happy mum · November 2, 2019

For Psoriasis: “Our son developed psoriasis at 14 whole body out of no where. He hid it for a long time but when he finally showed me I was heartbroken. Immediately we were referred to a skin specialist who put him on weekly methotrexate and within a week the results were staggering. He has now been on this drug for 6 years with regular blood testing all good results and it has changed his life. He will continue to take it as long as it works. Changed our lives and his life and mental well being to know he can show his body with no shame. He now takes 1 or 1.5 tablets once weekly and only ever has maybe one stubborn patch maybe on his elbows here and there. No side effects have ever happened ☺️”

10 / 10
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Anonymous · March 29, 2009

For Rheumatoid Arthritis: “At first I was really apprehensive about taking Methotrexate (7.5mg a week), but it seems to be working well. I've been taking it since November 2008. My side effects are minimal. Once a week I get nausea, which usually occurs the day after I take my weekly dose. My tests results have come back normal too. I 'm not a medicine taker and the idea of taking such a strong medication still scares me, but I will continue with my weekly dosage because it helps with my rheumatoid arthritis a lot. One thing I'm consistent with is taking my Folic Acid since it helps prevent my side effects. I don't even get the very common mouth sores.”

9 / 10
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momsrh · Taken for less than 1 month · August 29, 2018

For Rheumatoid Arthritis: “My family doctor and Rheumatoid specialists both suggested Methotrexate for my R.A. I read several sites and decided I would find my own way without this terrible drug. I went to India for Ayurvedic treatment, and as of today, not quite 2 years later, I have no pain, I have not suffered any side effects from this drug, and I can function normally. It pains me to see the accounts of people whose lives have been ruined by Methotrexate. There is a safer easier (and less expensive in the long run) to handle arthritis. Medical doctors will cringe to read this, but I'm living proof!!”

1 / 10
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Anonymous · September 23, 2012

For Rheumatoid Arthritis: “I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!”

10 / 10
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Mel · Taken for 6 months to 1 year · January 14, 2021

For Rheumatoid Arthritis: “Started methotrexate in April for RA, pain in hands, knees, hips, fingers and toes. Started on 7.5mg injections but didn't see any difference. Slowly progressed to 15 mg and I'm now just having odd pains here and there, mainly if I've overdone things. Started on folic acid 5mg ever day but it made me feel so ill, now only take it once a week which my rheumatologist is fine with and I feel absolutely fine. No adverse side effects from methotrexate either. Yes my hair is thinner but no so anyone notices, eyelashes a bit sparse now but still there. I was so apprehensive to try this drug but at 45 I didn't want it to progress to the stage where I couldn't live a normal life. I know it's not for everyone but for me it's really helped.”

8 / 10
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Brad - Texas · Taken for less than 1 month · May 13, 2018

For Psoriasis: “I am a 40 year old male, and I have been battling psoriasis for about 5 year. It started at the top of my scalp, moved behind my ears and patches around scalp and hairline. It then move down to my waist line, my penis and to my butt crack . For years now, I have had numerous different diagnosis, and a multitude of medications and theories. I finally met one doctor and he said simply… “You have inverse psoriasis, we will put you on methotrexate, no more guesswork“ This is literally the third day I have been on methotrexate and all remnants below the belt are almost 100% gone… Behind my ear is going away and my scalp plaques are literally disappearing already. I am so excited.”

10 / 10
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211106 · September 17, 2015

For Rheumatoid Arthritis: “When I was first diagnosed my hands hurt so badly I wondered how I could convince my doctor to amputate them and give me prosthetics. Methotrexate was among the first things tried to get my RA under control. After steroids, a variety of IV therapies, and anti-inflammatories Methotrexate has been my mainstay and keeps my RA under control as well as the biologics. I take it orally with no side effects. Yeah for Methotrexate in my life.”

9 / 10
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More FAQ

Nicky · Taken for 1 to 6 months · March 29, 2019

For Psoriasis: “For the past 40 years affected by psoriasis 20-30% of areas of my body including scalp and face. Mainly no itching. After heavy activity in sun, may be slight itching in some places. Tried so many medications. But only temporarily some methods cured my condition. Methotrexate in the form of dermatrex 10mg tablet one per week and folic acid tablets initially for the first two weeks 6 days a week and from third week onwards three days following the methotrexate. Within a months time all the skin eruptions gone. In the 2nd month Methotrexate 7.5 mg tablet once per week followed by folic acid tablet was specified. From third month on not taking any medicine. Two months gone - no problem. I will give a feed back in future.”

8 / 10
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willie · Taken for 10 years or more · September 25, 2019

For Psoriasis: “I'm 71 years old and have been taking Methotrexate (mtx) since I was 13 In all these years of using between 10-15 mg/ week I have never had a problem ... and yes, blood work every three months and precautionary (cya) liver biopsies over the years (all 11 of them scored a 4+ on a scale of 5 - tahdah). The results have always been positive - when I was younger and had severe psoriasis, the methotrexate (mtx) would slow it down, sometimes totally suppress it, the sun would help eliminate whatever was present and now that I'm (much) older, the mtx keeps me totally clear except during the winter months when things occasionally flare. My dermatologist has tried to get me on newer drugs but I've had such a lifelong success with the mtx, I won't change. I totally endorse trying it and I simply don't buy into it being more toxic than the newer items out there. (ps since its now generic, the price is way down ....) Good luck !”

10 / 10
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CCEA · August 13, 2015

For Rheumatoid Arthritis: “I took Methotrexate for 17 years. Started with tablets but progressed to injections for less chance of side effects (and cheaper!). Always felt tired and nauseous for a day after, which got worse and lasted longer over the years, so that instead of just folic acid, my rheum had me take leucovorin the day after (a stronger folic acid). But 6 months ago I developed fatigue, malaise and chronic low grade fever despite normal blood tests; my rheum said he had seen that before in other patients taking Methotrexate and considered it a toxic reaction! There is no literature on this reaction, but I got better once I stopped, so just be aware.”

5 / 10
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Savannah L · Taken for 1 to 2 years · December 22, 2019

For Rheumatoid Arthritis: “When I was first diagnosed with RA six years ago, this methotrexate was the first medication that I was prescribed. I was just in so much pain at that time and being newly diagnosed, I just wanted to feel like myself again. But ... over the course of the first three months, I gained just under 15 pounds. (And to make it worse I was so bloated, even though I was barely eating). Then ... worse yet, about nine months in to my treatment my long hair began to fall out (not in large clumps), but I started noticing my hair was all over everything. Okay, so now I have joint pain, I cannot fit in to my clothes, and my hair is falling out. I was taking this mediation for 14 months before I was changed, and throughout that time I am unable to say it really did anything to help me - although my doctor said it did stop “the flare up”. Please note: even though I no longer am on this medication, I did not actually notice this helping with my joints and I do still have flare ups occasionally.”

5 / 10
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tigger · Taken for 6 months to 1 year · September 10, 2019

For Rheumatoid Arthritis: “methotrexate was totally useless and side effect far outweigh benefits, unable to eat, hair falling out, chronic stomach pains. My RA doctor completely ignores when told the adverse effects and swaps to milder dose injection to no avail. Keep well away for this medication”

1 / 10
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Kimmy9519 · January 6, 2014

For Psoriasis: “Tried all other methods for relief of psoriasis, 80% of body. Have been on methotrexate for 5.5 weeks, belly, back, chest and forearms are all clear, very mild psoriasis that isn't red or irritated on upper arms and lower legs. My confidence and self esteem has increased heaps, excited to go for a swim 2nd time since I've had psoriasis (7 years). Only had bad fatigue for first few weeks, haven't drank any alcohol, healthy diet with minimal junk food, and nausea if I eat something really, fatty eg. pizza. Skin colour isn't yellowing nor getting black under the eyes, or anything else relating to bad liver. Would definitely recommend this medication. ”

10 / 10
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Ccd · August 29, 2018

For Rheumatoid Arthritis: “Please don't take this medicine. My mother had taken this once a week for 12years, it did help her RA but not greatly, then she died suddenly. An autopsy confirmed this medicine destroyed all her blood cells.”

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Bunionette · May 25, 2009

For Rheumatoid Arthritis: “I have been taking methotrexate for about 2 years for moderate rheumatoid arthritis (22.5mg weekly) and it does control inflammation. I recently stopped taking it for 3 months because I really don't like taking drugs and symptoms returned (inflammation in ankles, hip pain, stiffness) so I started taking it again and have no pain so obviously it was working.”

9 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.