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Medications for Eczema

Other names: Atopic Eczema; Dermatitis, Atopic; Discoid Eczema; Infantile Eczema

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 18, 2024.

Eczema can be managed through a variety of treatments including moisturizers, medicated shampoos, topical corticosteroids, topical calcineurin inhibitors, topical phosphodiesterase inhibitors, topical JAK inhibitors, oral JAK inhibitors, or injectable biologics. Oral infection control and symptom relief medications, oral immunosuppressants, and ultraviolet light treatments (phototherapy) may also be used. 

  • Moisturizers. These help retain skin moisture, repair damage, and alleviate dryness, redness, and itching. Examples include Dermaced Deep Therapy Eczema and EpiCeram Skin Barrier.
  • Medicated shampoos. These may contain ingredients such as ketoconazole (such as Nizoral), coal tar, or pyrithione zinc. They can help reduce symptoms of seborrheic dermatitis on the scalp (dandruff). 
  • Topical Corticosteroids. Available in OTC preparations (such as hydrocortisone) or prescription products which range in potency from:
  • Topical calcineurin inhibitors, such as pimecrolimus (Elidel) and tacrolimus (Protopic).
  • Topical phosphodiesterase-4 (PDE4) inhibitors such as Crisaborole (Eucrisa).
  • Topical JAK Inhibitors such as ruxolitinib (Opzelura) and delgocitinib (Corectim).
  • Oral JAK inhibitors such as abrocitinib (Cibinqo) and upadacitinib (Rinvoq).
  • Injectable biologics such as dupilumab (Dupixent) and tralokinumab-ldrm (Adbry).
  • Oral infection control and symptom relief medications, such as antibiotics or antivirals to treat infections or stop them from spreading; antihistamines (such as hydroxyzine, diphenhydramine, chlorpheniramine, or levocetirizine) to relieve itching and improve sleep; or pain relievers such as acetaminophen, ibuprofen, or naproxen.
  • Oral immunosuppressants, such as methotrexate, azathioprine, and cyclosporin, which reduce the overactive immune response.
  • Phototherapy including ultraviolet B (UVB) or ultraviolet A (UVA) light.

Drugs used to treat Eczema

The following list of medications are in some way related to or used in the treatment of this condition.

Filter
Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
triamcinolone 6.8 20 reviews for triamcinolone to treat Eczema
Rx C N
Generic name:
triamcinolone topical
Brand names:
Kenalog, Aristocort A, Cinolar, DermacinRx Trizapak, Dermasorb TA, Juulissa Pharmapak, Oralone, SilaLite Pak, Treziopak, Trianex, Triasil, Triderm, Tritocin
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Dupixent 6.7 208 reviews for Dupixent to treat Eczema
Rx N
Generic name:
dupilumab systemic
Drug class:
interleukin inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
mometasone 9.1 50 reviews for mometasone to treat Eczema
Rx C N
Generic name:
mometasone topical
Brand name:
Elocon
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
clobetasol 4.6 10 reviews for clobetasol to treat Eczema
Rx C N
Generic name:
clobetasol topical
Brand names:
Clobex, Temovate, Clobevate, Clodan, Cormax, Cormax Scalp, Embeline, Embeline E, Olux, Olux-E, Tovet
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
hydrocortisone 8.9 12 reviews for hydrocortisone to treat Eczema
Rx/OTC C N
Generic name:
hydrocortisone topical
Brand names:
Cortizone-10, Locoid, Beta HC, Locoid Lipocream, Ala-Cort, Ala-Scalp, Ala-Scalp HP, Aquanil HC, Aquax-H, Caldecort, Cortizone-5, Dermtex HC, Hydroxym Gel, Itch-X Lotion, NuCort, Pandel, Sarnol-HC, Texacort, U-Cort
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
dupilumab 6.7 217 reviews for dupilumab to treat Eczema
Rx N
Generic name:
dupilumab systemic
Brand name:
Dupixent
Drug class:
interleukin inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Elidel 7.4 48 reviews for Elidel to treat Eczema
Rx C N
Generic name:
pimecrolimus topical
Drug class:
miscellaneous topical agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
fluocinonide 8.2 10 reviews for fluocinonide to treat Eczema
Rx C N
Generic name:
fluocinonide topical
Brand names:
Fluocinonide-E, Vanos
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
desonide 9.1 20 reviews for desonide to treat Eczema
Rx C N
Generic name:
desonide topical
Brand names:
DesOwen, Desonate, Verdeso, DesRx, LoKara
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
prednisone 7.5 37 reviews for prednisone to treat Eczema
Rx C N
Generic name:
prednisone systemic
Drug class:
glucocorticoids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Elocon 9.0 36 reviews for Elocon to treat Eczema
Rx C N
Generic name:
mometasone topical
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
methotrexate Off-label 8.5 6 reviews for methotrexate to treat Eczema
Rx X N X
Generic name:
methotrexate systemic
Drug class:
antimetabolites, antirheumatics, antipsoriatics, other immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
pimecrolimus 7.3 52 reviews for pimecrolimus to treat Eczema
Rx C N
Generic name:
pimecrolimus topical
Brand name:
Elidel
Drug class:
miscellaneous topical agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Cortizone-10 9.3 3 reviews for Cortizone-10 to treat Eczema
OTC C N
Generic name:
hydrocortisone topical
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
dexamethasone 10 6 reviews for dexamethasone to treat Eczema
Rx C N
Generic name:
dexamethasone systemic
Brand names:
Dexamethasone Intensol, De-Sone LA, Dxevo, HiDex
Drug class:
glucocorticoids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
halobetasol 8.4 8 reviews for halobetasol to treat Eczema
Rx C N
Generic name:
halobetasol topical
Brand names:
Ultravate, Halonate
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
desoximetasone 8.3 10 reviews for desoximetasone to treat Eczema
Rx C N
Generic name:
desoximetasone topical
Brand name:
Topicort
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Kenalog 6.0 3 reviews for Kenalog to treat Eczema
Rx C N
Generic name:
triamcinolone topical
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
Topicort 8.0 2 reviews for Topicort to treat Eczema
Rx C N
Generic name:
desoximetasone topical
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
fluocinolone Rate Add review
Rx N N
Generic name:
fluocinolone otic
Brand names:
DermOtic Oil, Flac
Drug class:
otic steroids
For consumers:
dosage, side effects
For professionals:
Prescribing Information
fluocinolone 9.0 1 review for fluocinolone to treat Eczema
Rx/OTC C N
Generic name:
fluocinolone topical
Brand names:
Capex, Derma-Smoothe / FS, Derma-Smoothe / FS (Body Oil), Derma-Smoothe / FS (Scalp), Synalar, Synalar Ointment
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
fluticasone Rate Add review
Rx C N
Generic name:
fluticasone topical
Brand names:
Beser, Cutivate
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
azathioprine Off-label 9.0 1 review for azathioprine to treat Eczema
Rx D N
Generic name:
azathioprine systemic
Drug class:
antirheumatics, other immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Cloderm 10 2 reviews for Cloderm to treat Eczema
Rx C N
Generic name:
clocortolone topical
Drug class:
topical steroids
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Dexamethasone Intensol Rate Add review
Rx C N
Generic name:
dexamethasone systemic
Drug class:
glucocorticoids
For consumers:
dosage, interactions, side effects

Frequently asked questions

View more FAQ

Alternative treatments for Eczema

The following products are considered to be alternative treatments or natural remedies for Eczema. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Eczema.

Learn more about Eczema

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.