Fluocinonide topical Side Effects

For the Consumer

Applies to fluocinonide topical: topical application cream, topical application emollient cream, topical application gel/jelly, topical application ointment, topical application solution

Along with its needed effects, fluocinonide topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluocinonide topical:

• Blistering, burning, crusting, dryness, or flaking of the skin
• irritation
• itching, scaling, severe redness, soreness, or swelling of the skin
• redness and scaling around the mouth
• thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)
• thinning, weakness, or wasting away of the skin

Some side effects of fluocinonide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Fever
• headache
• muscle aches
• sore throat
• stuffy or runny nose
• unusual tiredness or weakness

• Acne or pimples
• burning and itching of the skin with pinhead-sized red blisters
• burning, itching, and pain in hairy areas, or pus at the root of the hair
• increased hair growth on the forehead, back, arms, and legs
• lightening of normal skin color
• lightening of treated areas of dark skin
• reddish purple lines on the arms, face, legs, trunk, or groin
• softening of the skin

For Healthcare Professionals

Applies to fluocinonide topical: compounding powder, topical cream, topical gel, topical ointment, topical solution

General

The most commonly reported side effects were burning, itching, irritation, and dryness.

Hypersensitivity

Postmarketing reports: Hypersensitivity^[Ref]

Endocrine

Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome^[Ref]

Local

Common (1% to 10%): Application site burning
Frequency not reported: Itching, dryness
Postmarketing reports: Discoloration, erythema, pruritus, swelling, pain, condition aggravated^[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Intracranial hypertension (including bulging fontanelles, bilateral papilledema)
Postmarketing reports: Dizziness^[Ref]

Dermatologic

Frequency not reported: Irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria
Postmarketing reports: Acne, dry skin, rash, skin exfoliation, skin tightness^[Ref]

Metabolic

Frequency not reported: Hyperglycemia, glucosuria^[Ref]

Respiratory

Common (1% to 10%) Nasopharyngitis, nasal congestion^[Ref]

Some side effects of fluocinonide topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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