Fluocinonide topical Side Effects

For the Consumer

Applies to fluocinonide topical: topical application cream, topical application emollient cream, topical application gel/jelly, topical application ointment, topical application solution

In addition to its needed effects, some unwanted effects may be caused by fluocinonide topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking fluocinonide topical:

• Blistering, burning, crusting, dryness, or flaking of the skin
• irritation
• itching, scaling, severe redness, soreness, or swelling of the skin
• redness and scaling around the mouth
• thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)
• thinning, weakness, or wasting away of the skin

Minor Side Effects

Some of the side effects that can occur with fluocinonide topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Fever
• headache
• muscle aches
• sore throat
• stuffy or runny nose
• unusual tiredness or weakness

• Acne or pimples
• burning and itching of the skin with pinhead-sized red blisters
• burning, itching, and pain in hairy areas, or pus at the root of the hair
• increased hair growth on the forehead, back, arms, and legs
• lightening of normal skin color
• lightening of treated areas of dark skin
• reddish purple lines on the arms, face, legs, trunk, or groin
• softening of the skin

For Healthcare Professionals

Applies to fluocinonide topical: compounding powder, topical cream, topical gel, topical ointment, topical solution

General

The most commonly reported side effects were burning, itching, irritation, and dryness.

Hypersensitivity

Postmarketing reports: Hypersensitivity^[Ref]

Endocrine

Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome^[Ref]

Local

Common (1% to 10%): Application site burning
Frequency not reported: Itching, dryness
Postmarketing reports: Discoloration, erythema, pruritus, swelling, pain, condition aggravated^[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Intracranial hypertension (including bulging fontanelles, bilateral papilledema)
Postmarketing reports: Dizziness^[Ref]

Dermatologic

Frequency not reported: Irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria
Postmarketing reports: Acne, dry skin, rash, skin exfoliation, skin tightness^[Ref]

Metabolic

Frequency not reported: Hyperglycemia, glucosuria^[Ref]

Respiratory

Common (1% to 10%) Nasopharyngitis, nasal congestion^[Ref]

Not all side effects for fluocinonide topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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