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Sernivo Spray

Pronunciation: ser-ne-vo
Generic name: betamethasone diproprionate 0.05%
Brand name: Sernivo
Dosage form: topical spray
Drug class: Topical steroids

Medically reviewed by Carmen Pope, BPharm. Last updated on Oct 26, 2023.

What is Sernivo Spray?

Sernivo Spray is a moderate to high potency corticosteroid that can be sprayed directly onto the skin to treat inflammation and itching caused by mild to moderate plaque psoriasis in adults aged 18 years and older. Although it is a spray, it feels like a lotion. Sernivo Spray contains betamethasone diproprionate 0.05% and should not be used for longer than 4 consecutive weeks.

Betamethasone dipropionate contains two esters - this makes it more fat soluble and increases its ability to penetrate the skin better. This makes it more potent than betamethasone valerate, which only contains one ester. Potency can also be increased by augmentation – this is when a substance, such as propylene glycol, is added to allow the active ingredient to penetrate the skin more quickly and work faster. Sernivo is a non-augmented betamethasone dipropionate cream.

Sernivo was FDA-approved on February 5, 2016.

Warnings

Do not use it for longer than 4 consecutive weeks. Use care when using on a large part of the skin. Talk with your doctor.

Sernivo Spray contains betamethasone diproprionate which can be absorbed through the skin into the bloodstream and cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency, including Cushing’s syndrome, hyperglycemia, and glucosuria. Do not use for longer than 4 weeks and do not exceed the recommended dose. Periodic monitoring for HPA suppression may be required.

Occlusive dressings should not be used unless under the advice of the doctor because these increase the risk of side effects.

Before taking this medicine

You should not use Sernivo Spray if you are allergic to it or any of the inactive ingredients contained in the spray.

Tell your doctor if you have ever had:

Topical corticosteroids can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.

Children are more susceptible to systemic absorption of topical corticosteroids and Sernivo Spray is not for use in children or young adults under the age of 18.

It is not known whether Sernivo Spray will harm an unborn baby. Tell your doctor if you are pregnant. If you are instructed to use the spray, use only a small amount and for the shortest time possible.

It may not be safe to breastfeed while using this medicine. If you are instructed to use Sernivo Spray, use only a small amount and for the shortest time possible. Do not apply to the breasts.

How do I use Sernivo Spray?

Spray Sernivo onto the affected areas twice daily. Rub in gently, then wash your hands after use, unless you have psoriasis on your hands.

Otezla, Cimzia, methotrexate, Humira, cyclosporine, adalimumab, Stelara, Enbrel, Tremfya, Remicade

What are the side effects of Sernivo Spray?

The most common side effects of Sernivo Spray include itching, burning, stinging, pain, and thinning of the skin (atrophy) at the treated site.

Topical corticosteroids can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency.

Other side effects reported with topical corticosteroids include:

Possible signs that you may be absorbing this medicine through your skin include weight gain in your face and shoulders, increased body hair, tiredness, mood changes, menstrual changes, and sexual changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Sernivo Spray?

Sprays applied to the skin such as Sernivo are not likely to be affected by other drugs you use. But you should not use Sernivo with other topical or oral corticosteroids, because they may have an additive effect.

Tell your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Does Sernivo interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Ingredients

Active ingredients: Each gram of spray contains 0.643 mg betamethasone dipropionate USP (equivalent to 0.5 mg betamethasone).

Inactive ingredients:  butylated hydroxytoluene, cetostearyl alcohol, hydroxyethyl cellulose, methylparaben, mineral oil, oleyl alcohol, polyoxyl 20 cetostearyl ether, propylparaben, purified water, and sorbitan monostearate.

Co-packaged with a manual spray pump for installation by the pharmacist before dispensing.

Supplied in 60 mL and 120 mL polyethylene bottles.

Storage

Store at room temperature 20°C – 25°C (68°F – 77°F). Do not freeze.

Manufacturer

Primus Pharmaceuticals, Inc.

Popular FAQ

How long does it take Sernivo to work?

In patients with mild-to-moderate plaque psoriasis using Sernivo (betamethasone dipropionate spray 0.05%), almost 75% of plaques on elbows and knees were clear or almost clear of redness and scaling after a period of 29 days. Treatment results, such as reduced itching, may begin as early as day 4. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.