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How should I use Sernivo Spray?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 14, 2023.

Official answer


Sernivo Spray is a prescription corticosteroid spray used on the skin. It is approved to treat mild to moderate plaque psoriasis in adults.

It is not recommended for use in patients under 18 years of age. Use only as directed by your doctor.

  • Your doctor will tell you how much to use and where to apply it.
  • Apply Sernivo Spray 2 times a day.
  • Do not use Sernivo Spray for longer than 4 weeks.
  • Wash your hands after applying.
  • Do not use on your face, scalp, underarms (armpits), groin, or areas where your skin may touch or rub together.
  • Do not bandage, cover, or wrap the treated skin area, unless your doctor tells you to.
  • Only use Sernivo Spray for the shortest amount of time needed to treat your plaque psoriasis.
  • Tell your doctor if your skin condition is not getting better after 4 weeks of using Sernivo Spray.

See “Instructions for Use” for detailed instructions about the right way to apply Sernivo Spray.

What are the most common side effects with Sernivo?

Sernivo Spray was well-tolerated in clinical studies over a 28-day period and few patients experienced side effects. Side effects occurred in 6% of patients or less.

The most common side effects (>1%) that were reported during treatment with Sernivo were:

  • itching
  • burning
  • stinging
  • pain
  • skin thinning

Sernivo Spray may pass through your skin and cause side effects with your adrenal gland. Your doctor may do blood tests to check for adrenal gland problems. These side effects are rare and may occur more frequently if you use Sernivo Spray at larger doses or for a longer period of time than recommended. Follow your doctor's instructions exactly.

See more side effects of Sernivo Spray (in more detail)

This is not all the information you need to know about Sernivo Spray for safe and effective use. Review the full Sernivo Spray information here, and discuss this information and any questions you have with your doctor or other health care provider.

  • Sidgiddi S, Pakunlu RI, Allenby K. Efficacy, Safety, and Potency of Betamethasone Dipropionate Spray 0.05%: A Treatment for Adults with Mild-to-moderate Plaque Psoriasis. J Clin Aesthet Dermatol. 2018;11(4):14-22. PMID: 29657667
  • Sernivo (betamethasone dipropionate 0.05% spray). [product label]. Encore Dermatology, Inc., Scottsdale, AZ.
  • Sernivo at work.

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