How long does it take Sernivo to work?
Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 24, 2020.
- In patients with mild-to-moderate plaque psoriasis using Sernivo Spray (betamethasone dipropionate 0.05%), almost 75% of plaques on elbows and knees were clear or almost clear of redness and scaling after a period of 29 days.
- Itching was decreased by 50% at day 4 in some patients, and significant treatment effects with Sernivo started as early as day 8 when compared to a vehicle treatment (spray with no active drug).
- Sernivo Spray is a mid-potency topical corticosteroid approved for up to 4 weeks of use to treat plaque psoriasis in adults.
In two clinical studies, 538 adult patients who had plaque psoriasis on 10% to 20% of their body surface area received treatment with Sernivo or vehicle. Treatment success with Sernivo was defined as clear or almost clear skin (Investigator Global Assessment) and at least a 2 grade reduction from symptoms present at the start of the study.
- By day 8, 11% of patients receiving Sernivo had achieved treatment success in one study, compared to 4% with vehicle (p=0.010)
- By day 15, 20.3% of patients receiving Sernivo had achieved treatment success, compared to 5% with vehicle (p<0.001) - the primary endpoint.
- By day 29, 38.7% of patients receiving Sernivo had achieved treatment success, compared to 12.6% with vehicle - secondary endpoint (p<0.001)
What are the most common side effects with Sernivo?
Sernivo Spray was well-tolerated in clinical studies over a 28-day period and few patients experienced side effects. Side effects occurred in 6% of patients or less.
The most common side effects (>1%) that were reported during treatment with Sernivo were:
- skin thinning
Sernivo Spray may pass through your skin and cause side effects with your adrenal gland. Your doctor may do blood tests to check for adrenal gland problems. These side effects are rare and may occur more frequently if you use Sernivo Spray at larger doses or for a longer period of time than recommended. Follow your doctor's instructions exactly.
See more effects with Sernivo Spray (in more detail)
How should I use Sernivo Spray?
Sernivo Spray is a prescription corticosteroid spray used on the skin. It is approved to treat mild to moderate plaque psoriasis in adults. Do not use Sernivo Spray for longer than 4 weeks.
Sernivo is not recommended for use in patients under 18 years of age.
- Use Sernivo Spray only as directed by your doctor.
- Apply Sernivo Spray 2 times a day. Your doctor will tell you how much to use and where to apply it. Wash your hands after applying Sernivo Spray.
- Do not use Sernivo Spray on your face, scalp, underarms (armpits), groin, or areas where your skin may touch or rub together.
- Do not bandage, cover, or wrap the treated skin area, unless your doctor tells you to.
- Only use Sernivo Spray for the shortest amount of time needed to treat your plaque psoriasis.
- Tell your doctor if your skin condition is not getting better after 4 weeks of using Sernivo Spray.
See “Instructions for Use” for detailed instructions about the right way to apply Sernivo Spray.
How much does Sernivo cost?
Sernivo Spray costs around $950 for a bottle of 120 mL if you are paying with cash, but most people do not pay this price. Prices are for cash paying customers only, using the Drugs.com discount card, and are not valid with insurance plans.
The manufacturer for Sernivo also supports a $0 or $45 copay patient savings program for eligible patients in the US, depending upon if Sernivo is covered by your insurance. Contact the manufacturer for more information.
Your final cost will vary based on your insurance coverage, insurance type and any discounts or coupons you may have. Prices may also vary depending on the pharmacy you visit or the area you are in.
- In patients with mild-to-moderate plaque psoriasis, almost 75% of knee and elbow plaques were clear or almost clear of redness and scaling after a period of 29 days.
- Itching was decreased by 50% at day 4 in some patients.
- By day 15, about 20% of patients receiving Sernivo had achieved significant treatment success, compared to 5% with the vehicle.
This is not all the information you need to know about Sernivo Spray for safe and effective use. Review the full Sernivo Spray information here, and discuss this information and any questions you have with your doctor or other health care provider.
- Sidgiddi S, Pakunlu RI, Allenby K. Efficacy, Safety, and Potency of Betamethasone Dipropionate Spray 0.05%: A Treatment for Adults with Mild-to-moderate Plaque Psoriasis. J Clin Aesthet Dermatol. 2018;11(4):14-22. PMID: 29657667
- Sernivo (betamethasone dipropionate 0.05% spray). [product label]. Encore Dermatology, Inc., Scottsdale, AZ. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208079lbl.pdf
- Sernivo.com. Spray on Sernivo. http://www.sernivo.com/spray-on-sernivo/#powerful-results
- Sernivo.com. Sernivo at work. https://hcp.sernivo.com/sernivo-information/
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- Sernivo Information for Consumers
- Sernivo Information for Healthcare Professionals (includes dosage details)
- Side Effects of Sernivo (detailed)