User Reviews for Methotrexate
Also known as: Folex PFS, Methotrexate LPF Sodium, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Methotrexate.
Reviews for Methotrexate to treat Psoriatic Arthritis
"Second time around with the methotrexate .I use it as a bridge drug until I find one that works. I was on enbrel and humira for past 15 yrs. both worked extremely well but lost potency after about 7 yrs. Now in search of new drug now trying Otezla it's not a biological and has less side effects of all others I have researched. I don't like the methotrexate. Long term because of hair loss and the continued dosing changes. But fortunately now we have many drugs to choose from finding one that works and is safe and effective is the dilemma."
Mattcat (taken for 1 to 6 months) September 16, 2017
0 users found this comment helpful.
"Was on 20mg dose and OK for a couple of years but by then I had put on 2 stone in weight then I started getting other side effects I put up with it for another 3 years but I had to come off it as to the problems I was getting eg. not eating properly sleep problems, mouth ulcers etc. I was put on sulphasalozine and lasted for three weeks and that did make me ill,"
ALFIE 1912 March 20, 2017
2 users found this comment helpful.
"33yo male, 8 years of Psoriatic arthritis with very minimal skin involvement, was prescribed MTX in triple therapy with Sulfasalazine and Hydroxychloroquinine for Psoriatic arthritis. After several months of dose escalation, unfortunately it did not help me at all, no major side effects either but no clinical efficacy."
Aussie Beau (taken for 1 to 6 months) February 5, 2017
1 users found this comment helpful.
"After becoming sick with this disease doctor initially started me on methotrexate pills and I developed what they call "phantosmia"...I smelled horrible things that weren't there. So we switched to injections and didn't get the smells anymore. Then he started Enbrel as well. I felt good for awhile and decided to stop the methotrexate because it was making me tired and weak. Two years later, I'm back on if because my back and neck were killing me and I'm getting 60-70%r relief after one shot of .8. Pretty happy about that but the trade off of sleeping all day and being weak and nauseated all reminded me of why I stopped too. But it does help so you weigh what's important to you."
Autoimmune mom in the desert November 17, 2016
3 users found this comment helpful.
"I only tried one dose which as a disaster. It did nothing to reduce the pain, first off. I got an immediate flare-up of my psoriasis symptoms on day 1. Days 2,3,4 I was so weak and faint I couldn't stand-up for more than 5 - 10 minutes. I was essentially bed-ridden and unable to eat much for 3 days! Also, I became extremely depressed and spent those 3 days in bed researching ways to kill myself (?!?) I also got mouth sores and bleeding gums. On day 7 the medication finally wore-off and I "snapped-out" of the depression as if a light-switch were turned back on. It was eerie and frightening to think a drug reaction would actually make me want to end my own life! I am sad it didn't work for me. I know others who use it fine."
Nat Kat (taken for less than 1 month) July 29, 2016
6 users found this comment helpful.
"Terrible experience - never again! I started taking the Methotrexate on Thursday morning and felt sick for days! I'm highly sensitive to medication and was given 10mg and 5mg of Folic Acid all days except dose day. I managed to get to work the next day but was very fatigued, vague and couldn’t function too well. I have never felt so tired as I did the weekend after and had to cancel all my plans. From Friday night, I was totally wiped out, no appetite, couldn’t stay awake, tummy ache, headache and since sunday strands of hair have been falling out. My fringe / bangs thinned out & hair kept falling out - after 1 tablet. It was a terrible experience."
Cleo-foxx (taken for less than 1 month) July 26, 2016
8 users found this comment helpful.
"positive no side effects"
davega July 18, 2016
4 users found this comment helpful.
"Never felt so Ill! I take 25mg weekly via injection. Never suffered side effects with other medication. This stuff is a horrible poison. Mouth ulcers,sickness that never goes away. Too many bloodtests to count. Constant fatigue. Dull depressed headache's and joint pain which means other pills,which means other pills to counter-act the side effects of the other lot! Ad-infinitum. Depressing really. On the plus side,(there is one suprisingly),more mobility. I am a resident of the UK so our health care system will be alien to you. We all contribute via an employment tax called NATONAL HEALTH CONTRIBUTION'S. And it i's the envy of the Western world. (when it works)"
BadgerboyToo July 9, 2016
5 users found this comment helpful.
"I'm curious can methotrexate cause weight gain I rarely eat anymore except for the three days leading up to my next dose I'm fatigued, headaches, weak food causes acid so I must be very careful that I eat bland foods with little fat and since I've only been on it for 5 weeks I'm in the MORE PAIN part of getting used to the meds part of all of this. But how could I possibly feel like I'm gaining weight when I eat next to nothing 4 out of 7 days and club crackers as my only snack"
Donna Varady June 7, 2016
5 users found this comment helpful.
"Works moderately well and with few side effects for me. I take 7.5-10mg a week along side 200mg twice daily hydroxycloroquine ( plaquenil) and 1mg folic acid 6 times a week ( not on my MTX day) . It's pretty cheap with insurance and even without it. The side effect that I get is metallic taste in mouth / tingles in my tongue towards my bottom teeth and loss of appetite ( which is common to me on any arthritis medications and ever since I got arthritis in the first place ) and feeling slightly sick after I take the pills. The drug definitely has had a positive effect on my pain levels though and has even led to a reduction in my overall meds . I'm feeling much better then I used to and am able to work and have a pretty normal life again."
Cash hardy (taken for 1 to 2 years) March 20, 2016
14 users found this comment helpful.
"Been on mtx for about 18 months. Just went from pills to injections and I'm fairly pleased. The day after doesn't seem as bad. Definitely will never go back to the pills. I get about 75% relief. I'll take that any day!"
Liberty's Noni (taken for 2 to 5 years) January 1, 2016
7 users found this comment helpful.
"Methotrexate has a profound effect on my life. I have been taking it for nearly 5 months and can walk freely again after 6 long months of suffering. I have experienced no major side effects and have even lost a little weight which was surprising. Another pleasing change was not only did my arthritis clear up rapidly but my skin has cleared as well. My nails are also smoother and less pitted. Methotrexate is truly a wonder drug. It has transformed my life. It is remarkable."
Megan NZ (taken for 1 to 6 months) August 26, 2015
26 users found this comment helpful.
"I have been using 20 mg for over a year with few side effects. It didn't take away pain and stiffness 100%, so my doctor included Humira. With both meds I am virtually pain free, stiffness and inflamation gone. Before I began treatment, I couldn't tie my shoes, write a letter, or open a jar. Now all of those activities are effortless."
MoneyMan (taken for 6 months to 1 year) September 22, 2013
39 users found this comment helpful.
"I've been on methotrexate for 3 years at 8 tablets (2.5 mgs). For some reason I only have psoriasis on my hands and then only my thumbs and the center of my inside right hand. That has cleared up considerably to where it is no problem. Thank goodness I have not got it anywhere else. I noticed that my knees, which had been painful, stopped hurting entirely after about six months. Before it was quite painful... now I have no pain. I haven't been taking the folic acid like I should."
Karinttt (taken for 2 to 5 years) April 9, 2013
26 users found this comment helpful.
"Been on methotrexate for a few years, started with one pill than nine pills. Now I do injection 25mg weekly for about a year now. I know there is no cure and I am thankful this medicine has made it possible to chase grandson around daily."
Anonymous February 17, 2012
50 users found this comment helpful.
More about methotrexate
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- 169 Reviews – Add your own review/rating
- Drug class: antimetabolites
- Methotrexate Injection
- Methotrexate Injection (Subcutaneous)
- Methotrexate Tablets
- Methotrexate Oral Solution
- ... +2 more