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User Reviews for Methotrexate to treat Rheumatoid Arthritis

Also known as: Rasuvo, Methotrexate LPF Sodium, Trexall, Otrexup, Xatmep, RediTrex

Methotrexate has an average rating of 6.1 out of 10 from a total of 111 ratings for the treatment of Rheumatoid Arthritis. 48% of reviewers reported a positive effect, while 29% reported a negative effect.

Methotrexate Rating Summary

6.1/10 average rating

111 ratings from 119 user reviews.

Compare all 305 medications used in the treatment of Rheumatoid Arthritis.

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Reviews for Methotrexate

Ducky January 24, 2021

“Im on methotrexate 2.5 mg four pills 1x a week for around 5-6 years for RA. I feel good when taking this medicine correctly and on time. I had got sick from taking too many antibiotics for urinary track infection and was told to stop taking methotrexate because I had to take a powerful medicine to get my health back to normal and methotrexate may interact with that medicine. I went off for almost 1 1/2 months and RA kicked in bad, I was finished with the other medicine so I went back on methotrexate and the RA subsided. My point is, this medication really does help and never just go off it because you don’t feel any pain anymore, and you think you are cured believe me it’s the medication that’s working, you are not cured you’ll always have RA. I take mine once a week every Saturday and I feel great, if you skip a dose or 2 believe me ,you will know you skipped it, take it every week same day same time and you’ll feel as though you are cured , and I have had no side affects what so ever.”

10 / 10
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LagWag · Taken for 1 to 6 months July 10, 2019

“This is a horrible drug. I took it once a week for 5 months, 12.5 mgs of awfulness. My hair started falling out in clumps, even with taking folic acid, the headaches and nausea are debilitating, along with the fatigue and general malaise that I experienced for 2-3 days after taking it. And it did not touch the flare ups or the pain I experienced from the RA. I have now completely changed my diet and my way of thinking to combat this disease. No gluten, no dairy, stress free as much as possible, and supplements like Nordic Fish Oils, Glucosamine and Chondroitin Sulfates and Turmeric help better than the Methotrexate did any day. I called this drug "Poison" the whole time I was taking it. Now I feel way better not taking and I know why, because it is a POISON. Stay far away from this drug and try life style changes before even considering this harmful drug.”

1 / 10
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rhirhi · Taken for 1 to 6 months November 6, 2018

“I have been on methotrexate for a couple of months now, I’m not certain whether we just caught my disease at a good time but this medication has been 110% effective for me. I have had no symptoms since it kicked in (took a while), the most that will happen because of the medication is the day after I take it I will feel a little tired (was worse in the beginning), anyways please make sure you don’t read reviews and judge the medication from that. I nearly scared myself silly doing that, trust in your rheumatologist and follow the process. The medicine reacts with different people in different ways, I am definitely one of the lucky ones. I am 25 and methotrexate has given me back the lifestyle of a 25 year old!”

10 / 10
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killedmymom4-16-19 · Taken for 10 years or more August 11, 2019

“My mom took methotrexate for over 15 years for R.A. She ended up methotrexate induced pulmonary fibrosis. The local hospital was treating her for pneumonia but that was not the case. Mom passed away at one of the nations top 10 hospitals from Acute Respiratory Distress Syndrome or Adult Respiratory Distress Syndrome. Death Certificate says she died from ARDS and RA. If you love yourself or your loved ones do not let them take this medication. DANGEROUS. She was 52 years old. I can't believe she gone and its all from a little yellow pill she took once a week. Low dose or not doesn't matter. IT CAN KILL YOU. AVOID. Read manufacturer black box warnings and find alternatives. The medicine didn't help much anyway if any.”

1 / 10
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Bexsy · Taken for 10 years or more April 23, 2019

“My mum has DIED, she had RA in hands & knees. She was given THIS DRUG 13yrs ago. NO 1 told her/us its ALSO ANTI-CANCER drug, it destroys immune system, blood cells etc. YES, it relieves RA, but in 6 months mum went from 6ft tall 10 stone lady to a wheezing, weak, 6 stone shadow of her former self, mum died April 7 2019, she was home & arrested. At hospital 10pm, 1am they said she wouldn't survive? They did EVERY test, bloods/fluids/scans, NOTHING showed. She had lines in neck, drips everywhere, they treated for lots & hoped it worked. But at 5am advised us TURN OFF her life support. Drs were baffled. When they got GP info, & we mentioned methotraxate their faces dropped, they didn't blame meds solely, but they DID explain meds have knock on effect, & with prolonged use they can cause break downs in parts of body. More info should be available, to look out for signs & symptoms about this drug. Please keep getting checked out. Mum had blood tests monthly & nothing showed, she NEVER missed appointment. I'd stay clear of these meds”

1 / 10
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Charis · Taken for 5 to 10 years September 22, 2019

“I took this medication for about 5 yrs. Dr increased the dose to 8 pills a week. While I was on this I experienced bad headaches, I would bruise easily & badly if I bumped myself somewhere. I also developed lactose intolerance. which I was not until I took this. Overall, this medicine was making me worse & in addition to this, Dr. would give me cortisone shots for my joint pain that never went away. Shots were bad too. After 5 yrs, I stopped taking this medication with out the Dr.s knowledge. I am now taking pure supplements and still fighting RA but I am methotrexate free for 6 yrs.”

1 / 10
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Yay December 28, 2018

“I am 32 year old and a mother of two boys working full-time. I was on methotrexate for 2.5 years (10 mg per week oral). It did work and I had little side effects in the beginning. However, about 1-1.5 years in I became extremely fatigued and even depressed. I did not feel like myself. I read in other blogs that people had the same feelings as I did so I was glad I wasn’t alone. I was at a point in my journey where I could try and get off the medication . After only two weeks off the medication I felt amazing! Back to my old self! Both my husband and I were amazed. Fatigue gone. No longer going to bed at 7:30 pm. No more depression feelings. And thank goodness my RA symptoms have not reappeared. I do follow a strict dairy free, gluten free, almost pescatarian diet that I believe has a huge impact on RA. So if anyone is feeling this way please talk to your doctor and try a different approach to tackling your RA if you cannot live with the frustration of the fatigue and depression.”

5 / 10
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Frequently asked questions

Anonymous March 29, 2009

“At first I was really apprehensive about taking Methotrexate (7.5mg a week), but it seems to be working well. I've been taking it since November 2008. My side effects are minimal. Once a week I get nausea, which usually occurs the day after I take my weekly dose. My tests results have come back normal too. I 'm not a medicine taker and the idea of taking such a strong medication still scares me, but I will continue with my weekly dosage because it helps with my rheumatoid arthritis a lot. One thing I'm consistent with is taking my Folic Acid since it helps prevent my side effects. I don't even get the very common mouth sores.”

9 / 10
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Mel · Taken for 6 months to 1 year January 14, 2021

“Started methotrexate in April for RA, pain in hands, knees, hips, fingers and toes. Started on 7.5mg injections but didn't see any difference. Slowly progressed to 15 mg and I'm now just having odd pains here and there, mainly if I've overdone things. Started on folic acid 5mg ever day but it made me feel so ill, now only take it once a week which my rheumatologist is fine with and I feel absolutely fine. No adverse side effects from methotrexate either. Yes my hair is thinner but no so anyone notices, eyelashes a bit sparse now but still there. I was so apprehensive to try this drug but at 45 I didn't want it to progress to the stage where I couldn't live a normal life. I know it's not for everyone but for me it's really helped.”

8 / 10
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jFr123 December 22, 2015

“Methotrexate has been a miracle for me. For the past 3 years experiencing extreme tiredness, no energy to do anything, thankful to get through a day's work. Tried every combination of vitamins the world has ever made without any results. Then over last one year severe inflammation of hands, could barely make a fist, difficulty using hands. Under rheumatologist advice used 2 other medications till placed on methotrexate with a dose of 5 pills per week. Have been on this dose past 8 months with great results. Have been walking, biking around from 2 to 4 miles frequently, mowing grass, doing property maintenance 6 to 8 hrs per day and still having energy to continue working on other things! Crossing fingers, THANKS METHOTREXATE!”

10 / 10
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Anonymous · Taken for 1 to 6 months June 5, 2015

“I have been on this medication for about 2 months now. I was taking prednisone before but that wouldn't help much. After the second week of taking methotrexate I can honestly say I am pain free. I can actually enjoy doing all the stuff I used to do before being diagnosed with RA. Before starting this medication I would experience horrible pain in my shoulders, hands, fingers, hips and ankles. I would have a rough time getting through the day. This medication works wonderfully.”

10 / 10
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momsrh · Taken for less than 1 month August 29, 2018

“My family doctor and Rheumatoid specialists both suggested Methotrexate for my R.A. I read several sites and decided I would find my own way without this terrible drug. I went to India for Ayurvedic treatment, and as of today, not quite 2 years later, I have no pain, I have not suffered any side effects from this drug, and I can function normally. It pains me to see the accounts of people whose lives have been ruined by Methotrexate. There is a safer easier (and less expensive in the long run) to handle arthritis. Medical doctors will cringe to read this, but I'm living proof!!”

1 / 10
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Anonymous September 23, 2012

“I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!”

10 / 10
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211106 September 17, 2015

“When I was first diagnosed my hands hurt so badly I wondered how I could convince my doctor to amputate them and give me prosthetics. Methotrexate was among the first things tried to get my RA under control. After steroids, a variety of IV therapies, and anti-inflammatories Methotrexate has been my mainstay and keeps my RA under control as well as the biologics. I take it orally with no side effects. Yeah for Methotrexate in my life.”

9 / 10
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Savannah L · Taken for 1 to 2 years December 22, 2019

“When I was first diagnosed with RA six years ago, this methotrexate was the first medication that I was prescribed. I was just in so much pain at that time and being newly diagnosed, I just wanted to feel like myself again. But ... over the course of the first three months, I gained just under 15 pounds. (And to make it worse I was so bloated, even though I was barely eating). Then ... worse yet, about nine months in to my treatment my long hair began to fall out (not in large clumps), but I started noticing my hair was all over everything. Okay, so now I have joint pain, I cannot fit in to my clothes, and my hair is falling out. I was taking this mediation for 14 months before I was changed, and throughout that time I am unable to say it really did anything to help me - although my doctor said it did stop “the flare up”. Please note: even though I no longer am on this medication, I did not actually notice this helping with my joints and I do still have flare ups occasionally.”

5 / 10
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tigger · Taken for 6 months to 1 year September 10, 2019

“methotrexate was totally useless and side effect far outweigh benefits, unable to eat, hair falling out, chronic stomach pains. My RA doctor completely ignores when told the adverse effects and swaps to milder dose injection to no avail. Keep well away for this medication”

1 / 10
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CCEA August 13, 2015

“I took Methotrexate for 17 years. Started with tablets but progressed to injections for less chance of side effects (and cheaper!). Always felt tired and nauseous for a day after, which got worse and lasted longer over the years, so that instead of just folic acid, my rheum had me take leucovorin the day after (a stronger folic acid). But 6 months ago I developed fatigue, malaise and chronic low grade fever despite normal blood tests; my rheum said he had seen that before in other patients taking Methotrexate and considered it a toxic reaction! There is no literature on this reaction, but I got better once I stopped, so just be aware.”

5 / 10
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More FAQ

Bunionette May 25, 2009

“I have been taking methotrexate for about 2 years for moderate rheumatoid arthritis (22.5mg weekly) and it does control inflammation. I recently stopped taking it for 3 months because I really don't like taking drugs and symptoms returned (inflammation in ankles, hip pain, stiffness) so I started taking it again and have no pain so obviously it was working.”

9 / 10
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Nana · Taken for 1 to 6 months February 18, 2020

“Been on methotrexate for five months now. It still makes me nauseous, and I hate continuing with these injections. I see my doctor in March. If I have to continue with them, I'm going to ask for oral instead. I still have a lot of pain in my hands, hips, back knees. Everywhere. Is this medication helping anybody?”

5 / 10
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Ccd August 29, 2018

“Please don't take this medicine. My mother had taken this once a week for 12years, it did help her RA but not greatly, then she died suddenly. An autopsy confirmed this medicine destroyed all her blood cells.”

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Gooddogs2 · Taken for 1 to 6 months November 2, 2018

“I have been on methotrexate for 6 weeks and have had no side effects. Has greatly reduced my RA symptoms along with 5mg daily dose of prednisone. I can walk again and no pain in hands. It’s worked well for me.”

9 / 10
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mamabear · Taken for 1 to 6 months February 27, 2019

“I was on 12.5 mg of methotrexate/week for 6 weeks. Gradually got more tired and more brain fog as each week went by. My hair was falling out at an alarming rate. By week 6 I was having heart palpitations. Joints felt good but everything else not so much. I stopped using and after 3 days felt much better.”

2 / 10
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Cocacolababy · Taken for 1 to 6 months November 22, 2014

“I have only been taking the Methotrexate since the end of September and I am on 25mg per week. I was also prescribed the Folic Acid but can't take that as it causes such an upset stomach that I stopped it all together. So far the only symptoms I have had were in the beginning and that was feeling nausea, and very tired the day after taking it. It has helped with the swelling and pain and I have no pain in my knees anymore and just a bit in the hands, wrists and my one foot.”

8 / 10
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Mister Moo · Taken for less than 1 month January 28, 2016

“Following treatment for acute auto-immune disease of the brain I suddenly developed RA symptoms in my hands and feet - dropping things all day, severe overnight swelling and pain. Two previous medications prescribed by my rheumatologist were ineffective. Tried Methotrexate (8 x 2.5mg once/week folic acid) two days ago and 50% of swelling and 90% of the pain are gone; can make a more-or-less painless fist with both hands, easy to type first thing in the morning (woo hoo) and happy to be alive.”

9 / 10
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JJ · Taken for 2 to 5 years January 3, 2020

“I was on methotrexate for 5 years, I started with pills then injections as I couldn’t handle the taste and it felt like it poisoned me made my brain feel awful - I couldn’t eat - it was the worse. I had 4 car crashes from poor judgement either on the day or day after using it. I developed a bleeding disorder and explode through my skin they have called it abnormal platelet dysfunction. They don’t know what the cause is but I think it was from methotrexate. I have had heart surgery and diagnosed with angina had a stent. Added to this I have ulcerative colitis. As well as Raynards syndrome and SLE. I don’t work or even look sick but I know one thing methotrexate was a nightmare compared to all heart issues I have had and are having. I’m still looking for a job I’m not disabled but have no energy to even type this ....”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.