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User Reviews for Methotrexate

Also known as: Folex PFS, Methotrexate LPF Sodium, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Methotrexate.

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User Ratings

10
   
26%(18)
9
   
19%(13)
8
   
18%(12)
7
   
10%(7)
6
   
6%(4)
5
   
12%(8)
4
   
2%(1)
3
   
5%(3)
2
   
2%(1)
1
   
5%(3)

Methotrexate Rating Summary

7.5/10 Average Rating

70 Ratings with 65 User Reviews

What next?Compare all 377 medications used in the treatment of Rheumatoid Arthritis.

Reviews for Methotrexate to treat Rheumatoid Arthritis

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"I was diagnosed with RA just under a year ago. I started with 10mg tablets with Folic Acid. Initially I suffered from a lot of nausea and bad sleep etc. I must confess though after the first diagnosis every twitch or cough made me think the worst. My Dr. upped my dosage to 12.5mg and changed me to the injection which she said should take away the nausea which worked but the pains remained. She also put me on anti inflamatory pills. Shortly after my last check-up in July, my pains have nearly completely subsided so I didn"

   
9.0

Laguiri October 25, 2016

11 users found this comment helpful. Did you?   Yes   No Report as inappropriate

"Methotrexate helps immensely with my rheumatoid arthritis pain. I know this because I became ill and couldn't get to the doctor for my blood tests so I ran out of my methotrexate and my pain increased dramatically."

   
8.0

rohise (taken for 2 to 5 years) October 25, 2016

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"I was started on Plaquenil when diagnosed with RA about two years ago at the end of summer. I told the doctor there was no way I would take MTX. By the following late spring I had what it took me a while to realize was a major flare-up. I already had one pointer finger that couldn't bend, and now the other one was stuck in the out position. I couldn't make fists. So I started on MTX once a week, along with 1 mg of folic acid/day. After about two months I began to see improvements. After a longer time my doctor said I was in remission. I take both Plaquenil and MTX, with few side effects. On my MTX day, and the day after, I'm sometimes low energy, and often slightly queasy. Not enough to keep me from eating entirely."

   
10

PearlRiver October 23, 2016

15 users found this comment helpful. Did you?   Yes   No Report as inappropriate

"I was put on Methotrexate by my specialist. I was on it for 3 months and had many side effects. I informed my Specialist who said it will pass and doubled my dose. I had 14 side effects and constantly had an upset stomach. I'm 28 so the whole not being able to get pregnant whilst on the drug is a bit of an issue. I am now on a new medication."

   
3.0

Katie-J October 23, 2016

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Otrexup (methotrexate): "I was in remission with Arava and oral methotrexate for 7 years, but stopped taking methotrexate because I didn't think I needed it anymore and I was slightly nauseated every time I took it. It was a big mistake because my feet are a hot mess. I became totally out of remission with major shoulder/neck pain and fatigue. I recently added Otrexup, in additional taking Arava. After 2 weeks I was pain free and my energy level has returned. I am paying $179 per month for Otrexup and it's a hardship. I am planning to discuss with my doctor going back on oral methotrexate which is only $10 per month."

   
9.0

karkeeki October 16, 2016

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"I have spondalopathy and My Enbrel was not as effective anymore and not long after taking my first dose of methotrexate in conjunction with the Enbrel the pain in my lower back was gone."

   
10

Historylover33 (taken for less than 1 month) October 8, 2016

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"I was diagnosed with JRA at 20, although I've had it since I was a very young age. I'm 44 now and I'm just beginning to take drugs for the disease, as my Drs only prescribed pain relievers. I've been on Methotrexate just short of a month. I'm very ill after I take it, and I have chest pain. Hopefully my body will get used to it and I'll be better. It's scary for me, and I keep checking the side effects."

   
5.0

AngB44 September 26, 2016

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"I was very ill on methotrexate for 10 weeks, nauseous,weak,pain in my chest. I was told I would get used to the side effects. After 10 weeks in ended up in ER vommiting blood requiring blood transfusions. Methotrexate was very dangerous for me and has destroyed my stomach. I found minocin very helpful until I pulled out infected root canal.... Instant relief. No pains now."

   
1.0

einyhealth (taken for 1 to 6 months) September 20, 2016

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"I have taken methotrexate for 4 years now and only when I was put on Humeria did I get any relief . the side effect I have had are depression and sweating but not hardly any stiffness and not much discomfort so for me the combination works for me ."

   
5.0

Keston (taken for 2 to 5 years) September 20, 2016

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"I had taken MTX in past but it did not work out for me due to rash proplem caused by MTX so Doctor recommended Sulfasalazine and it worked out very good for about 4 years but the end of friendship came to us...Sulfasalazine was not effective anymore. I met a Doctor who practice natrual madicine also ER Dortor at the local hospital....He recommended 3 natrual Supplements for RA and pain( Turmeric, Wobenzym N, White Willow) and they are very effective (on me) and it is better than Chemical based medications. I have been off from those deadly medications for 5 months now."

   
6.0

Turmeric September 14, 2016

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"I've been on methotrexate for 4 months now. The Rheumatoid arthritis came out of no where. I went to my primary care physician with me feet and my thumbs he basically said I was getting older to take aleve and get comfortable shoes. Well I month later I could barely walk so primary care physician did blood work. My RA factor was 1382. It took me another month to get an appointment with a rheumatologist. The rheumatologist is going to fail me on methotrexate on the 28 if this month because my levels are not coming down as expected. I am currently on 17.5mg of methotrexate. I take them on Friday night and Saturdays I am exhausted. I constantly have pain in my hands,wrists,ankles,knees and feet. I am just afraid the next med won't work either"

   
4.0

went September 11, 2016

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"I've been using Methotrexate for about a year. Haven't had any bad side effects. But when I started using the Plaquenil (generic form), the side effects where awful. My hands became red and very dry, cracking to the point of bleeding. I could not stop from scratching. I had dry, almost psoriasis' like patches on my wrist and arms. Had to stop taking it. All that went away. I'm still taking the methotrexate without any issues. Just have to keep up with the blood work. Now however, the dr. wants me to start on Humira, and I'm worried about the side effects that might cause. So, please, I need some feedback on Humira. What type of issues have any of you who take it, have had? Thanks!"

   
10

GW70 (taken for 6 months to 1 year) September 3, 2016

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"I was diagnosed with RA 2 years ago and am grateful that Methotrexate allows me to live a normal life, 20mg once a week, I have a flare every now and then which is managed by a steroid injection. i take 5mg Folic acid everyday to counteract side effects. I am tired on MTX day but generally have not experienced anything negative with the drug. However I take it last thing at night on the day I have to take it, and take it with Milk, I figure if there are any effects I would rather sleep through them, also I don't want to start taking a stomach acid medication so I tried it with milk and it was fine. It's worked for me."

Puz August 31, 2016

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"Roughly one year now and methotrexate has been working miracles. I started at 10 mg/week and eventually moved up to 12.5 mg/week. From the outset I was tapering off of 10 mg/day of prednisone but could not completely eliminate it until I moved the methotrexate up to 12.5 mg/week. Per doctors recommendation I'm also taking 5,000 mg of vitamin D daily and 1,000 mg of calcium daily (I don't eat much dairy). Side effects: None, except that I sometimes take a short nap after dinner on "methotrexate day" (I take it after lunch so as not to interfere with my pre-dinner martini(s)). Without methotrexate I could barely walk!"

   
10

WalkingAgain August 11, 2016

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"When I went to see my doctor, I couldn't even write my name. My hand hurt so badly I couldn't even hold a pen. She examined me, took blood work and gave me a steroid shot. A week later I returned and we discussed my options, and she recommended methotrexate. She went over the side effects ect, I'm into my second week, and I'm happy to say no side effects. 1 injection .06 once a week, folic acid daily. I'm at 80% better, and looking forward to 99%."

   
10

Jodiem54 August 6, 2016

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"I have been on Mtx for almost 2 yrs. I was diagnosed with JRA when I was 2 yo. I tried Plaquenil when I was about 19 and had an allergic reaction. I had a flare every 5 years or so in my adulthood and took an antibiotic that is prescribed as an off-label treatment for RA until my last flare 2 years ago when I finally gave in and decided to try the Mtx which I fought for years (I am 44). I take 17.5 mg once a week and 1 mg folic acid daily and have no side effects. It works well, but not perfectly and I do still have some pain. Right now I seem to be flaring and may have to try something more. I did try to lower my dose about 4 months ago but that was a disaster. I am glad I tried it and that it works for me."

   
8.0

Anonymous (taken for 2 to 5 years) May 31, 2016

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"Had a terrible experience with this drug. I would never take it again. This drug made me severely depressed to the point of suicidal thoughts. It also gave me a tight feeling in my throat. I Also learned that it could potentially create birth defects if your were to reproduce while on drug. I would recommend using a different option."

   
1.0

RA is not fun (taken for 1 to 6 months) May 28, 2016

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"I had taken methotrexate 21 years by the VA . plus Enbrel,Humira, folic acid and more ..well this is a warning ..I now have NASH it's a disease from the meds .cirrossis of the liver. Uncureable! Just change foods . Pray it doesn't get worse. WARNING. WARNING WARNING ,!"

   
10

Larrylorenzo May 14, 2016

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"After a severe case of Ross River Fever for which i was taking 50 mg Prednisone daily I developed chronic degenerative Polymyalgia Rheumatica, the pain in my arms, neck, hips, knees, hands and ankles was intense and never ending, i tried all the usual pain killers including Oxycontin and Methadone with varying short term success but the mind numbing daily struggle associated with taking Opiates was taking a toll on my life, my Rheum trialed me on 15 mg mtx weekly for 2 months and the result was incredible, the pain in neck and knees almost disappeared after the first week so the Rheum increased dose to 15 mg morning and night once a week, wow what a difference! few side effects and almost pain free, thank you MTX"

   
9.0

Ronnsy (taken for 10 years or more) May 12, 2016

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"I've been on Methotrexate for 9 months now 20mg once a week with 2 folic acids 2 days later my problem is that whilst the med is working its playing havoc on my liver I've had to come off it as my LFT results were constantly increasing then suddenly doubled. She asked me to have a Biopsy of my liver to work out if it is defiantly the Methotrexate or something else I guess this is what I need to do now. I've finally got myself down to 5mg Prednisone and now the Rheumo has said stop Mtx and see how you go if we need to we can up the Pred I don't want to up the Pred I eat like a horse and put so much weight on I'm hoping theres something else out there that will help me. Already tried Sulfazasaline and got a rash and other side effects."

   
7.0

Teish (taken for 6 months to 1 year) April 18, 2016

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"Been taking Methotrexate for almost 3 years now. Last fall, I felt good enough that I went off it without my Drs knowledge, because it made me feel pretty ill for a day or so after. What a mistake! I started taking it again about 2 months ago, and although it still makes me sick, it sure beats the pain I`m in without it. (on 25 mg a week, along with Hydroxychloroquin and folic acid)"

   
7.0

Macaroon5 March 6, 2016

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"I am 62, and was diagnosed with RA about 10 years ago, I have been through a battery of drugs to suppress my immune system, ending up on subcutaneous methrotrexate 10mg, I originally had a 'bad day' the day after my injections, however it seems to be getting to be a bad couple of days lately. Intense pressure head ache (I'm also a migraine sufferer), nausea, confusion, tiredness and now really troubled sleep, nightmares, and some visual disruption/ (almost hallucinations), feelings of panic, unease and claustrophobic. I know the alternatives, stop and face RA full on, but I would rather get 3/4 good days than be on the road to being completely disabled."

   
7.0

Nigel G (taken for 10 years or more) February 8, 2016

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"Been taking mtx, folic and Plaquinel for 1.5 yrs. My biggest side effect is lack of appetite. Not sure if it is the MTX or plaquinel causing this but as a result I feel I have no energy or muscle mass left. I wonder whether it is better to take the drugs or let the RA runs it's course. History of cancer in the family but not seeing any reference to that side effect here"

   
8.0

Jonseycanada February 3, 2016

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"Following treatment for acute auto-immune disease of the brain I suddenly developed RA symptoms in my hands and feet - dropping things all day, severe overnight swelling and pain. Two previous medications prescribed by my rheumatologist were ineffective. Tried Methotrexate (8 x 2.5mg once/week folic acid) two days ago and 50% of swelling and 90% of the pain are gone; can make a more-or-less painless fist with both hands, easy to type first thing in the morning (woo hoo) and happy to be alive."

   
9.0

Mister Moo (taken for less than 1 month) January 28, 2016

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"I have had rheumatoid arthritis 15 years severe & aggressive. Finding a good rheumatologist has been impossible. I take Humira, methotrexate, folic acid. Taking the prescribed dose of methotrexate10 mg once a week. I am so lethargic, still stiff hands, feet joints as well as pain. It is better than no medication because that pain is fire, this has dulled the fire. Had one surgery shoulder.. My hair has been rapidly falling out again, I can't eat normally. After reading this blog I realize I may do better with either injections or stopping completely. Planquenil, sulfa-salazine were of no benefit. Allergci to biologics. Had to find one that has been a game changer."

   
5.0

Sparks203 January 23, 2016

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