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User Reviews for Methotrexate to treat Psoriasis

Also known as: Trexall, Methotrexate LPF Sodium, Rasuvo, Otrexup, Xatmep RediTrex

Methotrexate has an average rating of 7.9 out of 10 from a total of 79 ratings for the treatment of Psoriasis. 73% of reviewers reported a positive effect, while 10% reported a negative effect.

Methotrexate Rating Summary

7.9/10 average rating

79 ratings from 84 user reviews.

Compare all 260 medications used in the treatment of Psoriasis.

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Reviews for Methotrexate

Happy mum November 2, 2019

“Our son developed psoriasis at 14 whole body out of no where. He hid it for a long time but when he finally showed me I was heartbroken. Immediately we were referred to a skin specialist who put him on weekly methotrexate and within a week the results were staggering. He has now been on this drug for 6 years with regular blood testing all good results and it has changed his life. He will continue to take it as long as it works. Changed our lives and his life and mental well being to know he can show his body with no shame. He now takes 1 or 1.5 tablets once weekly and only ever has maybe one stubborn patch maybe on his elbows here and there. No side effects have ever happened ☺️”

10 / 10
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Nicky · Taken for 1 to 6 months March 29, 2019

“For the past 40 years affected by psoriasis 20-30% of areas of my body including scalp and face. Mainly no itching. After heavy activity in sun, may be slight itching in some places. Tried so many medications. But only temporarily some methods cured my condition. Methotrexate in the form of dermatrex 10mg tablet one per week and folic acid tablets initially for the first two weeks 6 days a week and from third week onwards three days following the methotrexate. Within a months time all the skin eruptions gone. In the 2nd month Methotrexate 7.5 mg tablet once per week followed by folic acid tablet was specified. From third month on not taking any medicine. Two months gone - no problem. I will give a feed back in future.”

8 / 10
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Brad - Texas · Taken for less than 1 month May 13, 2018

“I am a 40 year old male, and I have been battling psoriasis for about 5 year. It started at the top of my scalp, moved behind my ears and patches around scalp and hairline. It then move down to my waist line, my penis and to my butt crack . For years now, I have had numerous different diagnosis, and a multitude of medications and theories. I finally met one doctor and he said simply… “You have inverse psoriasis, we will put you on methotrexate, no more guesswork“ This is literally the third day I have been on methotrexate and all remnants below the belt are almost 100% gone… Behind my ear is going away and my scalp plaques are literally disappearing already. I am so excited.”

10 / 10
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willie · Taken for 10 years or more September 25, 2019

“I'm 71 years old and have been taking Methotrexate (mtx) since I was 13 In all these years of using between 10-15 mg/ week I have never had a problem ... and yes, blood work every three months and precautionary (cya) liver biopsies over the years (all 11 of them scored a 4+ on a scale of 5 - tahdah). The results have always been positive - when I was younger and had severe psoriasis, the methotrexate (mtx) would slow it down, sometimes totally suppress it, the sun would help eliminate whatever was present and now that I'm (much) older, the mtx keeps me totally clear except during the winter months when things occasionally flare. My dermatologist has tried to get me on newer drugs but I've had such a lifelong success with the mtx, I won't change. I totally endorse trying it and I simply don't buy into it being more toxic than the newer items out there. (ps since its now generic, the price is way down ....) Good luck !”

10 / 10
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Kimmy9519 January 6, 2014

“Tried all other methods for relief of psoriasis, 80% of body. Have been on methotrexate for 5.5 weeks, belly, back, chest and forearms are all clear, very mild psoriasis that isn't red or irritated on upper arms and lower legs. My confidence and self esteem has increased heaps, excited to go for a swim 2nd time since I've had psoriasis (7 years). Only had bad fatigue for first few weeks, haven't drank any alcohol, healthy diet with minimal junk food, and nausea if I eat something really, fatty eg. pizza. Skin colour isn't yellowing nor getting black under the eyes, or anything else relating to bad liver. Would definitely recommend this medication. ”

10 / 10
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TPCDSecretary · Taken for 1 to 6 months October 18, 2015

“I was diagnosed with severe advanced plaque psoriasis in Dec, 2014. I was 60% covered when I first went to my dermatologist. By the end of Mar, 2015 after trying one ointment after another I was 95% covered, in pain (felt like 3rd degree sunburn), the itching was like a million fire ant bites 24/7. I couldn't lay down or sleep. The doctor started me on Methotrexate in May. Within 6 wks, I was totally clear and still am. (10/18/15) I take 2-2.5mg tablets Mon AM & again Mon PM then 1 Tues AM for a total of 12.5 mg a wk. I also take 1-1mg Folic Acid every day. I go in for follow ups and blood work every 3 mths but I'm fine now.... thanks to Methotrexate.”

10 / 10
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Pipeline girl January 16, 2013

“I have been on methotrexate for 2 1/2 years, I cleared up within 2 months and have stayed cleared up! Knowing you can only have so many grams in a certain amount of time makes me sad because soon I will have to stop taking it and switch to something different. I am 39 and have had psoriasis since I was 21. I can wear shorts and a t-shirt and feel normal. Methotrexate has given me my freedom back and I have had no side effects. If you have psoriasis you should give it a try, for me it's been so worth it.”

10 / 10
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Frequently asked questions

Aigoual · Taken for 6 months to 1 year August 12, 2016

“At age 66, after a very stressful phase of work over 7 months, I developed psoriasis very suddenly. With no previous skin problems & no family history of psoriasis either, I conclude that the stress was the trigger. I had the psoriasis all over but the worst was on my scalp - it felt like an iron band pressing in around my head. The dermatologist prescribed a whole range of creams and ointments over a year. Nothing worked. Finally in Nov. 2015 I was proscribed methotrexate + 1 folic acid tablet weekly. I was told it would take up to 3 months to kick in & it did, but in Aug.'16 I am virtually clear with no side-effects. The dosage has increased to 15 mg weekly & all my blood tests are normal. But will I have to stay on methotrexate for life?”

9 / 10
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AllClear May 7, 2016

“I was diagnosed with psoriasis at the age of 14. My life was hell by the time I was 18. It covered pretty much every where the sun didn't shine. I tried every thing topical, uv light and sun bathing, different diets you name it, I tried it. In my 30's I accepted that the only way I as ever going to have relief was by once every three or so months sun bath until I was so burnt it forced the psoriasis to slow down. I met a random stranger who saw my psoriasis and mentioned methotrexate. He told me his story, so I gave it a try. I hope the people who are complaining after six or even seven weeks stay the course. It took me four moths to see results. I am 40 now and have been %95 clear for the past eight years. 12mg once a week.”

9 / 10
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Mrs DT · Taken for 1 to 6 months June 9, 2014

“I have suffered with psoriasis since I was 19years old now in my 40s I have tried everything on the market, been on methotrexate since New Year's Day and I am so happy to say that it has nearly all gone. I holiday with all my friends and don't feel embarrassed, I am so happy. I would recommend, it's a slow process but five months in and pretty much clear. No side effects, tired on day of medication but that's no issue.”

9 / 10
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scaly girl · Taken for less than 1 month December 30, 2013

“I have had psoriasis on my scalp since I was a baby with "Cradle Cap.'' It was left untreated until I was about 21. I have tried every cream and t-gel out there. Nothing cleared it up fully. Since I turned 24 the condition has spread to other parts of my body, usually parts that don%u2019t get much light. Psoriasis is terrible and affects everyone so differently. This condition has kept me from getting close to people and even kept me from going to hair dressers. Finally I decided to start this medicine. I'm currently on my fourth week of 15mg oral methotrexate. I have noticed a huge decrease in itching and my patches seem to be not as scaly. I really hope this works, so far so good.”

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AndyW September 3, 2015

“I have been taking a 15 mg weekly dose (three doses of 5 mg at 12 hour intervals once a week) for five weeks now. My psoriasis -- pretty heavy scaling on all joints, and "splatter" over pretty much the whole body, which I've had for 18 years (I'm 51) -- has gone almost completely (still a little bit on elbows, knees, and ankles; hands and rest of body are completely clear). Yes, early days, but hopefully.... My only suggestion is to get empty gelatine capsules (or gelatine substitute if you are vegetarian; harder to get hold of) and put the tablets in them before taking. Helps avoid stomach upset.”

10 / 10
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abushy · Taken for 1 to 6 months February 27, 2017

“I was diagnosed with psoriasis about 1.5 years ago at the age of 24. It was severe in my scalp, ears, elbows, hands, knees, legs and feet. I've tried every single remedy out there. Every cream and ointment the derm prescribed. Finally; I stood my ground and needed a change; it was affecting my everyday life terribly. I've been on the methotrexate 15mg and folic acid 1mg for about two months now and my elbows, hands, feet are clear, my elbows and scalp have decreased dramatically! I have absolutely no side effects which was my biggest fear! Life is good! It's amazing!”

10 / 10
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Kimber321 · Taken for 1 to 2 years November 4, 2013

“This drug greatly helped my psoriatic arthritis, but not the plaque poriasis, which always came back. I've been through the scrip topicals, light treatments, Amiveve, etc. I was 98% covered. Why did not a single doctor ever tell me NOT to touch beer???? If you drink beer put it DOWN and see how quickly you begin to clear up. Pork is another culprit as it is slow to digest and effects the immune system. For topical relief? Try OTC Boudreaux's Butt Paste baby diaper rash cream, which far outshines Dovonex. Scalp treatment? Nutrogena T-Gel Shampoo works quickly. If you are severely covered add zinc or zinc supplements to your diet. I haven't gone to a derm in years and I am clear!!!!”

7 / 10
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LeopardHat · Taken for 6 months to 1 year May 6, 2014

“I live in the UK & have had plaque psoriasis for 20 yrs. After various lotions, UVB & PUVA, my knees & elbows became infected and I could hardly walk or sleep with the discomfort. As I also have depression, my dermatologist decided on prescribing methotrexate as my quality of life was so severely affected. I take 15mg tablets once a week, within a month it had all but gone, & has remained that way. It has been a year since I started, it's such a relief not to think about my knees all the time! I also take folic acid, & the skin on my face has become quite oily, but it's definitely worth it. I've recently noticed the few patches I have left are beginning to increase in size, but I hope this improves with the arrival of summer!”

9 / 10
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fluffynut · Taken for 6 months to 1 year April 5, 2013

“I've had severe psoriasis which covered me head to toe since I was 5 I'm now 30. Tried every trick in the book from lotions and potions, light therapy & homeopathic remedies. I put off taking methotrexate for fear of becoming a glow in the dark alien with the side effects! Finally gave in last year and so glad I did. It cleared within 3 weeks. I'm now on 15mg a week and only have slight patches of psoriasis dotted about. Had a few bad headaches now and then but nothing extreme. A little wobbly on the blood tests but nothing life threatening just yet. Much better quality of life at the min, and much less hoovering haha.”

9 / 10
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dw-massachusetts September 4, 2011

“I have had psorisis all my life (45 yrs). I have been a methotrexate user for 12 years. Before I started using methotrexate I was covered about 90%. Today it is about 1%. Over the years along with blood work. I have had 3 liver biopsy. I have had no side effect.”

9 / 10
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More FAQ

Anonymous · Taken for 6 months to 1 year May 26, 2012

“It works great! I have had Psoriasis all my adult life and only two things have worked. The first was the original Skin Cap spray from Spain but that disappeared after the U.S. government got involved. This was second. I have been on methrotrexate 2.5mg tablets for 6 months and was fully clear within the first month. No stomach problems and no other side effects. If you suffer from psoriasis, do yourself a favor and find a doctor that will work with you to try it.”

10 / 10
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danske May 7, 2018

“I watched a good friend (with psoriasis) deteriorate on this vile drug, taken in rotation, 3 months on, 1 month off for over 3 years. 1 month off? Yes, to give the liver a 'chance to recover'. Really?! His liver suffered so badly, he died within 3 years - from liver and pancreatic cancer. From the beginning of being on this drug my friend's digestion suffered increasingly, as did his immune function. He was always in denial about the role methotrexate played in his poor health - because it did cure his hated psoriasis.”

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evlinaa · Taken for less than 1 month August 24, 2017

“I have been with psoriasis for the past ten years. I went to 3 different doctors, specialist. I treated for an anti fungus condition, and I was also treated for ringworms too. I have tried everything apparently available on the shelves, and it cost me so much money too. Went online and found a clinic. With only positive reviews. give it a go, and I was prescribed Methotrexate- for only five days. I swear my skin has cleared 85 percent. No itchy, tiny patches. All my friends haven't stop complimenting me. Now I must say that I have been using only paraben free kinds of stuff for hairs and body and kept moisturizing with Aveeno. (no peanuts at all)it's a super trigger for psoriasis- my laundry is also washed with only baby products.”

10 / 10
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Juju a October 6, 2014

Methotrexate LPF Sodium (methotrexate): “Seeing marked improvement in little over 48 hours of receiving injection. Psoriasis is 2/3 s the coloration as before . After 54 years of having this I am pleasantly surprised. Thought it would work much slower. At this point I am thrilled. No side effects yet !”

8 / 10
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Arouran Moon · Taken for less than 1 month September 13, 2013

“Started taking methotrexate approx. 1 and a 1/2 weeks ago. Already have seen significant improvements. I have had over 75% coverage of psoriasis from head to toe since my teens and I am now 45. Minor troubling side effect include slight nausea, bad fatigue and dizziness. These clear up after I finish my three day treatment. Positive outweighs the negative. I am scheduled for my first liver test on Oct 1st. In my opinion ...worth it!”

10 / 10
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Scaly April 2, 2016

“For all the people just starting MTX for psoriasis...patience, it takes time!!!! I have had psoriasis for 20 years worse every year for the last decade, tried ointments, UV therapy, all sorts diets in vain. Started MTX 7.5mg weekly 4 months ago, feeling heart broken the first couple months as I saw no change, but it is happening... at turtle speed I am clearing. After 3 months the itch stopped now I am VERY SLOWLY clearing ( as long as I don't take any alcohol). Dermatologist said at such low dose expect best benefit around 6 months. No side effects!”

10 / 10
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Josie83 · Taken for 2 to 5 years May 30, 2017

“I've suffered with scalp psoriasis from being 8 years old but always managed with coal tar shampoos. When I was 29 I noticed plaque psoriasis forming on the trunk of my body, arms and legs, chest and face! They grew larger, became intolerable and so itchy. After many visits to the GP I was eventually referred to a dermatologist. By this point I was off work severely ill, my skin was so bad I couldn't walk, I would lie in the bath to help shed the layers of skin. Upon my visit to dermatologist he took one look and said I was critical. I was 99% covered and had erythrodermic psoriasis! I spent 11 days in hospital bandaged in ointments. I've been on MTX for 4 years now and can say they have helped me a lot (99%). Blood monitors done 3 monthly. ”

9 / 10
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NW Eire · Taken for 1 to 6 months April 9, 2015

“Age 59, F, living N W Eire. No history of psoriasis until it struck 2 yrs ago. Small plaques on scalp, left elbow, then palms of hands, fingers & soles of feet. Itchy, shredding skin, burning as if stung by nettles. Open, painful cracks. Emollients, lotions, prescription creams had no effect. Water & detergents irritated. Touch & walking agony. Latex gloves for shower/chores, cotton gloves at work. Dermatologist found 'debilitating stage 2 psoriatic arthritis' prescribed 2.5 Methotrexate x6 once wkly plus Folic Acid and bloods checked wkly. Now 7th week. Plus: using hands & walking, no irritation. Neg: tired, poor focus, urinary infections, worse in bad weather, still avoiding water/detergents. Conclusion: Highly recommend Methotrexate”

7 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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