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User Reviews for Hydroxychloroquine

Also known as: Plaquenil

Hydroxychloroquine has an average rating of 6.5 out of 10 from a total of 321 ratings on Drugs.com. 53% of reviewers reported a positive experience, while 27% reported a negative experience.

Condition Avg. Rating Reviews Compare
Rheumatoid Arthritis  
6.2
139 reviews 363 medications
Systemic Lupus Erythematosus  
7.1
70 reviews 101 medications
Sjogren's Syndrome  Off-label
6.4
51 reviews 3 medications
Undifferentiated Connective Tissue Disease  Off-label
6.4
43 reviews 1 medications
Lyme Disease, Arthritis  
7.2
10 reviews 36 medications
Dermatomyositis  
6.1
8 reviews 16 medications
Summary of Hydroxychloroquine reviews 6.5 321 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Hydroxychloroquine

Hot Dog · Taken for 10 years or more · May 20, 2020

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I am 76 year old female with Rheumatoid Arthritis for about 40 years. I have been on Plaquenil for about 30 years which has controlled pain and swelling of joints. X-rays have shown decrease in joint destruction. I have multiple drug reactions but have had none with Plaquenil. I do have occasional flare in rainy, cold weather which is gone in about 2 days with anti-inflammatory. I see my ophthalmologist once a year for extensive eye exam. To date no problem. Very, very pleased with Plaquenil and love my Rheumatologist.”

10 / 10
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TJT1 · January 22, 2016

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I have been on Plaquenil since 1996 when I was diagnosed with RA. When I was diagnosed I was in severe pain, unable to hold my infant child or drive. My rheumatologist injected me with steroids to get me immediate relief and started me on Plaquenil. I don't remember my initial dosage but I take 200mg once per day and have been in remission since 1996 and I have had no side effects that I am aware of. I have regular eye exams and periodic screenings by a retinologist and my eyes have had no issues at all.”

10 / 10
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Mike · Taken for 6 months to 1 year · August 4, 2019

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “It started as Palindromic Arthritis, then progressed to full fledged RA with frequent flares attacking my shoulders, elbows, wrists, knees and even my jaw. Most attacks would severely limit my physical abilities. The doctor suggested Humira, I was little reluctant - too many side effects to think about. She said we could try Plaquenil - a milder drug. I was told it takes two months before patients feel any improvement, it took little less for the drug to kick in. Now, it's been a year - I have no flares, no pain and no side effects I can think of. I take one pill in the morning, one in the evening. This drug works well for me.”

10 / 10
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Will · Taken for 1 to 6 months · December 16, 2019

For Rheumatoid Arthritis: “I welcome the chance to comment on my personal experience with Hydroxychloroquine (generic). Please keep in mind that these comments are based on my experience only. My rheumatologist prescribed two 200 mg tablets per day. After two months I discontinued the medication because I was experiencing a number of nasty side-effects, which included: dizziness, disorientation (even in familiar places and times), extreme fatigue (slept 16 hours per day), periodic shortness of breath, loss of cognitive abilities, blurred vision, headaches, metallic taste in mouth, excessive itching (but not hives), little improvement of inflamed joints, insomnia, nausea, extreme intestinal disruption, forgetfulness, and overall lack of energy. I realize some with RA praise the drug, and I am happy it works for them. But I found it a nasty, quality-of-life inhibiting drug. Thanks for reading!”

3 / 10
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Ace · Taken for 10 years or more · May 14, 2019

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “Hi, I was taking the generic form of plaquenil for over 10 years for rheumatoid arthritis. It took a few weeks to see it work but what a change for the better. Less painful joints and fatigue. Always have gotten retina checked and have been good. Then I started getting debilitating migraines. I went off my meds one by one and the GENERIC was to blame. My pharmacy switched to another foreign cheap manufacturing co. My doctor told me many generics change their fillers which cause side effects. Since I’ve been off I have declined rapidly. I’m trying to find assistance for original brand. It’s outrageous that we are forced to get generics! Especially if a person has a reaction we should be able to get brand at same or reasonable prices. Which they are not. This drug was so helpful for me and its worth a try, give it 2-6 months. Good luck!”

10 / 10
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Daughter #5 · Taken for 1 to 6 months · December 21, 2012

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “My 19 yr old daughter was diagnosed with rheumatoid arthritis this past year...her inflammation markers were off the charts. She took meloxicam for a couple of months, but it really hurt her stomach to where she couldn't eat. They put her on Plaquenil about 6 months ago...she is doing great. Recently had blood work and her inflammation is almost all gone...no side effects for her. I hope this medicine can help other people.”

10 / 10
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Anonymous · November 10, 2019

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “Hi all. Been on Plaquenil for 30 years for rheumatoid arthritis. I don’t know if I have side effect from this drug as they are intermittent... Itching - weird times not consistent Eye watering - constant Headaches - hormonal, RA related Always had thin hair - never fell out No stomach issues ever Get eyes checked 1x a year. My eye dr puts me through an hour+ battery of tests (4?) and takes a picture of my eye every year (cool machine ... don’t have to dilate). Blood work every three months to monitor kidneys. Starting to wonder if I need to increase because my shoulders starting to loose range of motion and had bursitis a few weeks ago in one. Or maybe I need to increase prednisone (also 30 years - 5 mg once a day).Been off the anti-inflammatory diet though ... will get back on it, too. Starting gym on Tuesday .... Stay healthy folks!”

10 / 10
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Frequently asked questions

Kat019 · Taken for 1 to 6 months · March 3, 2017

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I began taking Plaquenil for RA 1 month ago. Despite information from my doctor that it would be at least 3 months before I see an appreciable effect, I am feeling better than I have in the last year. Prior to Plaquenil, I tried Mobic & Medrol, both with limited improvement. But over the last few weeks I have been able to play basketball with my son again, move without thinking or a 'warm up period', return to the gym, begin Pilates & I've lost 12 pounds! I did have some GI upset over the last month, but nothing I would consider stopping this medication for. I am able to enjoy things again & live life without discomfort.”

9 / 10
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lwinslow · Taken for 5 to 10 years · May 2, 2013

Plaquenil (hydroxychloroquine) for Sjogren's Syndrome: “Before Plaquenil, I would be in bed for days at a time, unable to move, excessive pain, ice cold, migraines, the whole gamut. My body felt ancient. At first the rheumatologist thought I had leukemia, then Lupus and rheumatoid athritis and finally biopsies started giving us a more refined treatment plan. With this medicine, I am in much less pain. I can walk for an hour at a time. I can shop for groceries again. I feel like I have a life again. I have had brief periods, never more than a month without it, and I know that life without the benefit of Plaquenil is no life at all. Yes, I have to see the retina specialist but in all this time, my eyes are fine. Don't hesitate to try it even though new treatments can be scary!”

10 / 10
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geezergirl · September 5, 2016

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I've been on this drug since 2003. Before meds, I was so sick with RA symptoms. Spent 19 hours a day in bed, couldn't dress or bath myself. Seldom ate. Doctor put me on 200 mg. plaquenil twice daily and 10 mg. prednisone and I got my life back. I've since drop prednisone and am down to 200 mg. once daily plaquenil. About to go on the generic form of plaquenil. A little concerned. Is the quality the same? My specialist said no. RA drugs are so scary. I've had friends die on biologics--and some go blind. My advice as geezergirl. When you find out what works for you, hold on tight to it.”

10 / 10
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Mickey · Taken for less than 1 month · December 26, 2020

For Lyme Disease, Arthritis: “Unbelievable! I’ve suffered with Lyme Disease for several years. 2 days ago I began taking Hydroxychloroquine for treatment of Covid-19 exposure. The first morning after I had taken 400 mg I felt fantastic! Even my neck pain was completely gone and I felt awake and alive! How can I get HCQ to treat Lyme? What’s the proper dose and length of treatment? Feels so good! Glad I got exposed to Covid19 (sniffles) and decided to do the HCQ treatment! Now I know it’s treating Lyme! Wow!”

10 / 10
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Darkchief99 · June 6, 2017

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “Haven't taken this. Just wanted to read some feedback. I was on methotrexate, but stopped, because it gave me chills, fatigue and shortness of breath, I even fainted at work. The doctor suggested Plaquenil as a possible alternative, but after reading some of the comments, I don't think so. This is really frustrating and sad. The FDA should NOT be approving these crappy drugs which can cause worse problems than the one you have. I honestly don't know what to do, let the RA turn me into a cripple or take my chances with one of these death drugs?”

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Enz · Taken for 2 to 5 years · February 15, 2018

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “Well I posted once before, figured I would give another update for anyone who cares. It's been around 2 years now and I'm glad to say all side effects are long gone. So is my pain for the most part. Sometimes I forget I was even diagnosed with RA (Palindromic Rheumatism). Every once in awhile I will have a flare, my last one was in October of last year 2017, it is now Feb 2018 and still flare free. I've been seeing gaps of 6+ months without any pain. You can see why it's easy to forget lol. Again, this drug is worth it. It seems almost like a dream waking up and not being able to move, a horrible dream.”

10 / 10
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RichEsq · April 13, 2017

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “Love this drug, compared to the others. I am 55 now, and first took it 30 years ago. My RA then came on lightening fast, nodules and all. I went from totally normal to almost wheel chair in weeks. The weight of a bed sheet on my toes was too much. Two plaquenil a day and 2400 mg of ibuprofen a day ( that's 12 regular dose!) and I went into total remission. Of course my stomach is crap now. After 25 years of remission, the RA returned. Different now that I'm older (55), more subtle. Chose plaquenil again, and working wonders, but for my permanent damage. Get your eyes checked, a must. Some hair will fall out, but hey, I'm glad I still have some to fall out. WEIRD dreams. Irritability. Will lose weight! TAKE WITH FOOD to avoid cramps.”

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KittensAussiePrincess · March 26, 2017

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I've been on Plaquenil for over 3 months now. It works wonderfully! I combine my treatment with Curcumin & Magnesium baths and I feel like a new woman :-) Side effects I experienced: Nausea & dizziness for the first week or two (I found I needed to take it after a full meal to prevent the nausea). I have also noticed since starting the Plaquenil I seem to sweat profusely. It's annoying, but the benefits far outweigh this little problem. I just wear my gym gear about now... which I did mostly beforehand anyhow :-) Also, it take take a couple months for the Plaquenil to kick in & for me to feel the effects! Don't give up, just give it some time.”

7 / 10
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Ohsooz · Taken for 1 to 6 months · November 16, 2014

Plaquenil (hydroxychloroquine) for Sjogren's Syndrome: “I was diagnosed with Sjogrens Syndrome 3 months ago. I also have rheumatoid Arthritis and Hashimotos. My rheumatologist prescribed Plaquenil in hopes to control all 3 conditions. I would say that Plaquenil has basically given me my life back. I suffer from debilitating joint pain, fatigue, brain fog and extreme anxiety. I had to quit working because as a high school teacher, brain fog and anxiety, are probably 2 of the worst things you should be dealing with when dealing with teenagers. I would give Plaquenil a 10, but I haven't been on it long enough to see the full effects. I continue to have more energy every day, I'm back to walking, as exercise, again and my joint pain is very well controlled.”

8 / 10
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ShellyBeans333 · Taken for less than 1 month · September 3, 2017

Plaquenil (hydroxychloroquine) for Systemic Lupus Erythematosus: “I've been taking this medicine for 4 days. I have not experienced any negative side effects yet. No nausea or jittery feelings like others I've read about. Since starting this medicine I've noticed I've slept like a rock. No waking up at all and no problems falling asleep. I just felt I should share this observation since I was terrified to start after reading all these horror stories. Not everyone is negatively affected.”

10 / 10
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The Law · Taken for 1 to 6 months · July 2, 2013

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I was told that I have rheumatoid arthritis a few months back. I have been on Plaquenil now for almost 2 months. It has helped with the pain in my hands and feet. I still have swollen fingers but am waiting for the full affects of the drug. I do not know how common this is but the side effect that I am having is hair loss. I am guessing it wouldn't be as bad if I was a male but being a female. I am hoping this stops after my body gets used to the medicine because I am very discouraged with that aspect.”

7 / 10
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cjgriff · Taken for 10 years or more · October 27, 2015

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “This medication did wonders for my soreness and pain from Rheumatoid Arthritis but if someone would have told me I would have devastating and irreversible eye damage due to taking it, I would have chosen a different drug for sure (at least after the 5-7 year mark when it is known to cause major problems that will be with you for life!)”

3 / 10
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Enz · Taken for 1 to 6 months · July 25, 2016

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I started on Plaquenil for RA about two months ago so my experiences are fresh. I'm a large male at 6'2 250 pnd 30 years old. When I was diagnosed with RA I didn't know what to expect. I was quickly referred to a Rheumatologist who recommended this drug. The first three weeks I was having some side effects. Nose bleeds, ringing in my ears. But after the fourth week they just disappeared. As well as the excruciating pain in my feet, knee's and hands. It just poof like it never happened. I'm optimistic about now my third month as it has now been three months since my last flare up. It was too late for my feet, which now have permanent damage, but I can now walk and wear shoes almost perfectly normally.”

9 / 10
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HogFan · Taken for 1 to 2 years · December 20, 2015

For Rheumatoid Arthritis: “I was told by my doctor that plaquenil would not work for my RA because my symptoms were too severe. However I didn't want to take the other more serious drugs, so I took this. It took a month before I noticed ANYTHING, and after two months I felt MUCH better. Now, a year into the drug I have ZERO, and I mean ZERO symptoms of RA. Give it time. It works.”

10 / 10
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Holly · November 13, 2018

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I've been on a roller coaster for yrs w/Plaquenil for RA/Lupus. I take name brand to prevent side effects of red, warm, swollen, painful hands + nausea/dizziness, hair loss, etc. Each time I try going back to generic, side effects return immediately. I'm not one to comment but I read so many reviews that sounded like either my ups or downs, so I want to encourage ppl to stick w/this med & try name brand (though expensive) if having bad side effects w/generic. It could explain why some ppl have such opposite experiences. I get Plaquenil from international pharm & it's much cheaper. It works better than biologics that contributed to/sped up process leading to my cancer. I'm now "cancer-free" & refuse to go back on them. I might have to get vision checked & deal w/other mild side effects, but pain/swelling is gone on Plaquenil. Anyway, pls hang in there & give your body enough time to adjust to med before stopping it. It's a risk vs. reward scenario w/meds.”

9 / 10
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chelle1989roses · October 5, 2014

Plaquenil (hydroxychloroquine) for Systemic Lupus Erythematosus: “I am a RN and have been diagnosed with undifferentiated connective tissue disorder. I was initially very hesitant to start medication due to the side effects. I have been on the medicine for three years. I have had increased joint mobility and decreased swelling. I do have my eyes examined every six months. Glad I weighed my options and gave it a try.”

9 / 10
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pjtremblay · September 11, 2011

Plaquenil (hydroxychloroquine) for Sjogren's Syndrome: “This medicine has changed my life. I'm a nurse with primary Sjogren's Syndrome. It took 10 years for a diagnosis and another 10 years for a rheumatologist to prescribe Plaquenil. I have never felt so good. Minimal joint point, lots of energy, able to sleep at night, what could be better! I was able to complete an eye exam for the first time in 9 years. I'm enjoying life pain free and with energy!”

10 / 10
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cherired · July 9, 2015

Plaquenil (hydroxychloroquine) for Rheumatoid Arthritis: “I had very bad experiences with this medication . I now have permanent toxicity of my system and I also develop medically induced cataracts from this medication even though I have stopped taking the medication it will continue to try and rob me of my sight. eyes always swollen running very painful. every morning when I rise I look like a monster face full of fluid input all around my eyeslike a little Sacks of fluid. is there is help out there I would like some and I will like to know if there's a manufacturer lawsuit the information for this medication does not tell you about the damage that it does. now they are warning doctors to let patients know about this medication and the bad side effe and let them know if they want to take it.”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.