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Hydroxychloroquine Dosage

Applies to the following strength(s): 200 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Malaria Prophylaxis

Suppression: 400 mg (310 mg base) orally on the same day every week

Comments:
-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg (620 mg base) may be taken in 2 divided doses (6 hours apart).
-Suppressive therapy should continue for 8 weeks after leaving the endemic area.
-Each dose should be taken with a meal or a glass of milk.

Use: Malaria prophylaxis

Usual Adult Dose for Malaria

Acute attack: 800 mg (620 mg base) orally followed in 6 to 8 hours by 400 mg (310 mg base), then 400 mg (310 mg base) once a day for 2 consecutive days; alternatively, a single dose of 800 mg (620 mg base) has also been effective

Alternate dosing based on body weight:
A total dose representing 25 mg/kg is administered in 3 days, as follows:
First dose: 10 mg base/kg (not to exceed 620 mg base) orally
Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose
Third dose: 5 mg base/kg orally 18 hours after second dose
Fourth dose: 5 mg base/kg orally 24 hours after third dose

Comments:
-Each dose should be taken with a meal or a glass of milk.
-Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria.

Use: For the treatment of acute attacks of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum

Usual Adult Dose for Systemic Lupus Erythematosus

Initial dose: 400 mg (310 mg base) orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response
Maintenance dose: 200 to 400 mg (155 to 310 mg base) orally daily

Comments:
-Each dose should be taken with a meal or a glass of milk.
-Retinopathy has been reported to be higher when the maintenance dose is exceeded.

Use: For lupus erythematosus (chronic discoid and systemic) in patients who have not responded satisfactorily to drugs with less potential for serious side effects

Usual Adult Dose for Rheumatoid Arthritis

-Initial dose: 400 to 600 mg (310 to 465 mg base) orally once a day to optimum response (usually 4 to 12 weeks)
-Maintenance dose: 200 to 400 mg (155 to 310 mg base) orally once a day
Dose adjustment: The dose may need to be reduced temporarily if adverse side effects occur; after 5 to 10 days the dose may gradually be increased to the optimum response level

Maintenance dose: 200 to 400 mg (155 mg to 310 mg base) orally daily

Comments:
-This drug should be taken with a meal or a glass of milk.
-Side effects may require reduction in the initial dose for 5 to 10 days; the dose may then gradually be increased to the optimum response level.
-The compound is cumulative in action and will require several weeks to exert its beneficial therapeutic effects, whereas minor side effects may occur relatively early.
-Several months of therapy may be required before maximum effects can be obtained.
-If objective improvement (such as reduced joint swelling, increased mobility) does not occur within 6 months, therapy should be discontinued.
-Safe use of this drug in the treatment of juvenile rheumatoid arthritis has not been established.
-Retinopathy has been reported to be higher when the maintenance dose is exceeded.
-Should a relapse occur after medication is withdrawn, therapy may be resumed or continued on an intermittent schedule if there are no ocular contraindications.
-Corticosteroids and salicylates may be used in conjunction with this drug, and they can generally be decreased gradually in dosage or eliminated after the drug has been used for several weeks. When gradual reduction of steroid dosage is indicated, it may be done by reducing every 4 to 5 days: the dose of cortisone by no more than from 5 mg to 15 mg; of hydrocortisone from 5 mg to 10 mg; of prednisolone and prednisone from 1 mg to 2.5 mg; of methylprednisolone and triamcinolone from 1 mg to 2 mg; and of dexamethasone from 0.25 mg to 0.5 mg.

Use: For acute or chronic rheumatoid arthritis in patients who have not responded satisfactorily to drugs with less potential for serious side effects

Usual Pediatric Dose for Malaria Prophylaxis

Infants and children:
Suppression: 5 mg/kg (calculated as base) orally on exactly the same day each week; the dose should not exceed 400 mg regardless of weight

Comments:
-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 10 mg/kg (calculated as base) may be taken in 2 divided doses (6 hours apart).
-Suppressive therapy should continue for 8 weeks after leaving the endemic area.
-Each dose should be taken with a meal or a glass of milk.

Use: Malaria prophylaxis

Usual Pediatric Dose for Malaria

Infants and children:
Acute attack:
A total dose representing 25 mg/kg is administered in 3 days, as follows:
First dose: 10 mg base/kg (not to exceed 620 mg base) orally
Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose
Third dose: 5 mg base/kg orally 18 hours after second dose
Fourth dose: 5 mg base/kg orally 24 hours after third dose

Comments:
-Each dose should be taken with a meal or a glass of milk.
-Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria.

Use: For the treatment of acute attacks of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Precautions

US BOXED WARNINGS:
-Physicians should completely familiarize themselves with the product information before prescribing this drug.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Take with meals or a glass of milk.

General:
-This drug is not effective against chloroquine-resistant strains of P falciparum.
-Beneficial effects may take several weeks to manifest; however, minor side effects may appear relatively early after therapy is initiated.

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