Hydroxychloroquine Alternatives Compared
| Hydroxychloroquine | Methotrexate | Enbrel |
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| Hydroxychloroquine | Methotrexate | Enbrel etanercept |
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Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria, Rheumatoid Arthritis, Systemic Lupus Erythematosus. May also be prescribed off label for Lichen Planopilaris... View more |
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more |
Choose a suggestion below Rheumatoid Arthritis
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| More about Hydroxychloroquine | More about Methotrexate | More about Enbrel (etanercept) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Hydroxychloroquine has an average rating of 6.5 out of 10 from a total of 321 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 27% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 263 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
Enbrel has an average rating of 7.8 out of 10 from a total of 261 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full hydroxychloroquine side effects document. |
Commonly reported side effects include: increased liver enzymes. See the full methotrexate side effects document. |
Common side effects include: infection, injection site reaction. See the full Enbrel side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all hydroxychloroquine prices |
View all methotrexate prices |
View all Enbrel prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Plaquenil | Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | Other etanercept brands include: Erelzi, Eticovo | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
15 hours |
300 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category N
Not classified
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 441 drugs are known to interact with hydroxychloroquine:
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A total of 625 drugs are known to interact with methotrexate:
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A total of 420 drugs are known to interact with Enbrel:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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N/A |
December 07, 1953 |
November 02, 1998 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.