Comparing Chloroquine vs Hydroxychloroquine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Chloroquine

Hydroxychloroquine

Prescription only

Prescribed for Malaria, Malaria Prevention, Sarcoidosis, Amebiasis. Chloroquine may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Rheumatoid Arthritis, Lupus, Lyme Disease - Arthritis, Lichen Planopilaris, Dermatomyositis, Malaria Prevention, Malaria, Sjogren's Syndrome, Undifferentiated Connective Tissue... View more

More about Chloroquine

More about Hydroxychloroquine

Ratings & Reviews

Chloroquine has an average rating of 10.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.

Hydroxychloroquine has an average rating of 6.4 out of 10 from a total of 356 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 29% reported a negative effect.

View all 2 reviews

View all 356 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Chloroquine side effects

Nausea (11.8%)
Rash (9.3%)
Pain (7.9%)
Fatigue (6.7%)
Headaches (6.7%)
Hair loss (5.6%)
Upset stomach (5.1%)

View all Hydroxychloroquine side effects

Drug Class

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	25 tablet
Strength	500 mg
Per unit^*	$7.56
Cost^*	$188.90

View all Chloroquine prices

Quantity	50 each
Strength	200 mg
Per unit^*	$1.26 - $1.48
Cost^*	$63.03 - $74.19

View all Hydroxychloroquine prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

282 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 527 drugs are known to interact with Chloroquine:

199 major drug interactions (623 brand and generic names)
314 moderate drug interactions (1262 brand and generic names)
14 minor drug interactions (48 brand and generic names)

A total of 586 drugs are known to interact with Hydroxychloroquine:

224 major drug interactions (717 brand and generic names)
346 moderate drug interactions (1289 brand and generic names)
16 minor drug interactions (50 brand and generic names)

Alcohol/Food/Lifestyle Interactions

You may want to limit your consumption of grapefruit or grapefruit juice during treatment with... View more

You may want to limit your consumption of grapefruit or grapefruit juice during treatment with... View more

Disease Interactions

First Approval Date

October 31, 1949

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Hydroxychloroquine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Chloroquine vs Hydroxychloroquine

See also:

Plaquenil

Flagyl

Ozempic

Vibramycin

Cleocin

Monodox

Malarone

Mepron

Oracea

Coartem

Further information

Comparing Chloroquine vs Hydroxychloroquine

See also:

Further information

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