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User Reviews for Hydroxychloroquine to treat Systemic Lupus Erythematosus

Also known as: Plaquenil

Hydroxychloroquine has an average rating of 7.1 out of 10 from a total of 61 ratings for the treatment of Systemic Lupus Erythematosus. 61% of reviewers reported a positive effect, while 21% reported a negative effect.

Hydroxychloroquine Rating Summary

7.1/10 average rating

61 ratings from 69 user reviews.

Compare all 39 medications used in the treatment of Systemic Lupus Erythematosus.

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34%
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16%
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10%
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8%
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5%
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3%
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2%
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Reviews for Hydroxychloroquine

ShellyBeans333 · Taken for less than 1 month September 3, 2017

Plaquenil (hydroxychloroquine): “I've been taking this medicine for 4 days. I have not experienced any negative side effects yet. No nausea or jittery feelings like others I've read about. Since starting this medicine I've noticed I've slept like a rock. No waking up at all and no problems falling asleep. I just felt I should share this observation since I was terrified to start after reading all these horror stories. Not everyone is negatively affected.”

10 / 10
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chelle1989roses October 5, 2014

Plaquenil (hydroxychloroquine): “I am a RN and have been diagnosed with undifferentiated connective tissue disorder. I was initially very hesitant to start medication due to the side effects. I have been on the medicine for three years. I have had increased joint mobility and decreased swelling. I do have my eyes examined every six months. Glad I weighed my options and gave it a try.”

9 / 10
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Ashley · Taken for less than 1 month January 15, 2020

Plaquenil (hydroxychloroquine): “I've been taking Plaquenil for 6 days now and I already notice a difference in my SLE. I almost feel normal. Before I struggled with fatigue and pain. Since its a mild stimulant it helps with my energy and my body is feeling so much better. I can't wait for a month to be up to see the results more clearly. I'll update then.”

9 / 10
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Lou Lou · Taken for 1 to 2 years February 2, 2020

Plaquenil (hydroxychloroquine): “At first it made me very sick nauseous all day but figured out for me I could take it with peanut butter it coated my stomach enough to make me not nauseous. Took about 3 months to start helping joint pain and it has continued to help more the longer I’m on it, I still get joint pain flares here and there but much shorter time frames.”

9 / 10
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osborne113 · Taken for 1 to 2 years October 29, 2014

Plaquenil (hydroxychloroquine): “I would recommend this to anyone. I was put on Plaquenil in April of 2012 for Lupus symptoms, constant pain( mostly in my legs) extreme fatigue and overall ill feeling. Within 2 months of taking Plaquenil the pain and fatigue had subsided, not completely but has greatly improved over the last year and half & my health and immune system has also improved and I went from being sick ALL the time to very rarely sick. It has been a Godsend for me. I wouldn't advise taking the medicine on an empty stomach it will make you sick & nauseous all day long.”

10 / 10
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LarryF June 11, 2015

Plaquenil (hydroxychloroquine): “I first went on Plaquenil in 2004, due to unbearable finger and wrist joint pain for 5 months, which was diagnosed as Lupus (after a sky-high ANA test and some other tests and diagnoses). I was told it would take 3-ish weeks to kick in, and it did, right on schedule. Almost overnight, I went from not able to hold a soda can or open a door to being 100 % pain free. I was on Plaquenil for 4 years, during which time I was in complete remission, so in 2008 I discontinued it. In 2015 Lupus reared its ugly head again, this time with Pleurisy. Got back on Plaquenil and after the requisite waiting time, it got the problem under control (not 100%; maybe 50 %). I love Plaquenil but my advice to others is to be very patient and give it time to work.”

10 / 10
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Mrs. Boss Ross February 19, 2012

Plaquenil (hydroxychloroquine): “For mild cases of lupus (meaning no organ involvement) I would say this works perfectly fine. Reduces fatigue and joint pain from a 10 to about a 2 depending on weather conditions. If you are active and maintain a healthy diet I would say fatigue and pain are at a nil while taking Plaquenil. It takes maybe a few months to get the dosages correct with your level of pain and fatigue.”

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Frequently asked questions

amandafromneworleans January 13, 2019

Plaquenil (hydroxychloroquine): “Plaquenil Users Beware: Drug can make you completely blind: re: toxic maculopathy I took Plaquenil for over 13 years. One retina specialist said because of the toxic maculopathy it caused. *even if you quit taking the drug, it can continue to damage the eye until blindness occurs. If you are taking it, make sure your physician is using the NEW guidelines on treatment ==I think it is no more than 5 milligrams per kilogram If you have ANY changes in your vision, friends, head to a retinal specialist--1 test I had an angiogram done. Are there any support groups or experimental therapies for toxic maculopathy? I found EyePromise Restore Vitamins that I take for retina health my Dr. says will help ”

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a new me March 6, 2008

Plaquenil (hydroxychloroquine): “This drug gave me back my life. I suffered with chronic cyclical arthritis that felt like it was in every joint. The fatigue was devastating. Even if I slept for hours I still woke up feeling no better. I was scared to take this drug but eventually I had to do something. Thankfully, I have no side effects. I only have very occasional arthritis and am no longer tired. It has given me back my life. I do have my eyes checked 2x/yr.”

10 / 10
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Mel · Taken for 1 to 6 months July 22, 2019

Plaquenil (hydroxychloroquine): “Several years ago took Plaquenil for over two years, took about 6 months before it was effective. I have now restarted again this time it has become effective in about 10 weeks, no measurable side effects and less pain....”

9 / 10
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Cass888 · Taken for less than 1 month August 27, 2017

Plaquenil (hydroxychloroquine): “I'm in Australia , only just started this medication a week ago but I feel a less fatigued already. I was stuck in bed most days, but now I can go longer without needing to go to bed or feeling like I'm going to collapse. I haven't noticed any bad side effects yet either which is good! As I get nauseated and dizzy on meds easily and haven't found that to be the case! I just wanted to point out that some people hear a lot of bad things that aren't necessarily reported or true. Like I noticed a woman on here said she needs to stop taking it because of the tinnitus side effect means she might go deaf. But deafness hasn't been reported, just tinnitus as a side effect whilst taking it. Don't be so afraid if it's going to give u your life back”

8 / 10
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Joanna · Taken for 5 to 10 years December 29, 2019

Plaquenil (hydroxychloroquine): “I have been taking for five years. My ALE is on the mild to moderate side of things thank goodness. I regularly get my vision screened and so far so good. My arthritis has gotten much worse and is affecting almost all of my small joints in hands and feet. The only thing I have noticed has been a gradual darkening of my skin. Which would be okay if it was an even darkening but alas, only in blotches. Can't really say if Plaq helps me and am considering discontinuing it.”

6 / 10
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Not impressed · Taken for less than 1 month September 20, 2019

Plaquenil (hydroxychloroquine): “Started taking Plaquenil 5 days ago for bad butterfly rash caused by dermal lupus. I’m extremely dizzy, bad stomach pain, ringing in the ears, etc... I’ll deal with the rash this is way to harsh. This is why pharma scares me so much. In bed on beautiful sunny day, can’t even walk my dogs so dizzy.”

1 / 10
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deziner June 5, 2008

Plaquenil (hydroxychloroquine): “I have been on this medication since February 2008. I have more energy and less fatigue. I still have my days, but this medication is a God send. Initially, my hair began to thin, but with supplements and proper hydration for my hair, it has levelled and is beginning to thicken again. If you are taking this medicine and have some of the side effects, please give it some time. I am glad I did.”

10 / 10
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Tjmoney · Taken for 2 to 5 years April 28, 2019

Plaquenil (hydroxychloroquine): “I am African-American 55 years of age. I developed sores on my leg, hearing loss problems, heart rate increased, dizziness all the time, balance problems while walking, mouth sores, weakness of lower legs I had to use mobile chair I became so weak, made quality of life worst.”

1 / 10
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small town mom May 28, 2014

Plaquenil (hydroxychloroquine): “I have been on this medication for about 12 years now. It seems to work very well but as the years have gone on it doesn't work quite as well as it used to. That's why I only rate it at an 8. There was a time when my insurance was messed up, and I didn't have the money to pay for my medications. I could definitely tell the difference when I was not on this medicine. I would definitely recommend it.”

8 / 10
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CTT October 13, 2015

Plaquenil (hydroxychloroquine): “I started this med as I have both RA and Systemic Lupus. It did nothing for me and we added Methotrexate, still no benefit. Added Enbrel, no better. My eyesight was beginning to fail so I stopped all of them. My weight ballooned up by 25lbs!! I have found no mainline meds to help and had to turn to Traditional Chinese Medicine for relief. Works great for me. I am still hoping to find something in the regular vein of meds to help and not hurt me. My insurance will not cover the help of the Traditional Chinese Medicine that is helping. What's up with that?”

1 / 10
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PBHi · Taken for 2 to 5 years May 29, 2014

Plaquenil (hydroxychloroquine): “I have been taking 200mg of Plaquenil daily for 2yrs now. I still have many days a wk when my entire body hurts. My eye doctor cautioned me not to go to a higher dose for the protection of my eyes. Recently, my daughter noticed a film over half of one eye, which I could not see and my vision is generally not as clear. May not be the right medicine for me.”

6 / 10
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Raye · Taken for 2 to 5 years November 16, 2020

Plaquenil (hydroxychloroquine): “I took Plaquenil for Lupus for 4 years. It causes eye pain, chest pain, stomach pain and gave my face a melasma appearance that is irreversible. It did NOT help with RA or Lupus symptoms at all, but my doctor wants me to stay on it or see a different doctor.”

1 / 10
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Bell · Taken for less than 1 month March 22, 2020

Plaquenil (hydroxychloroquine): “I started taking plaquenl about 2 weeks ago for SLE and if I had been drinking around the time I’m suppose to take my pill I just wouldn’t take it and I missed about 2 days and this has been my worst flare up. No side effects. I’m moody but that’s just a normal 21 yr old female. Don’t be hesitant to try this because anything is better than the pain of chilblains and joint pain. Will update in a few months.”

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MK · Taken for 5 to 10 years October 11, 2019

“Plaquenil is a unique drug that helps control/suppress certain autoimmune symptoms. Plaquenil will not work for everyone with autoimmune issues. But there are other drugs like Erythromycin, Azithromycin, Doxycycline, Fluconazole, Malarone, ect. that may work better for your autoimmune condition. Also, taking 100mg of Doxycycline an hour before the Plaquenil allows the Plaquenil to work more effectively, by breaking down the biofilm of the cells allowing the Plaquenil to penetrate the cell faster and more effectively. If you have fungal related issues like Pleurisy, Edema legs, circulatory issues, thickening of your blood, certain heart issues, or clotting of arteries, etc., a drug like Fluconanzole twice a day with aspirin for at least 6 weeks up to 6 months may actually help relieve those types of symptoms. Everyone is different; the key is having a physician that will help figure out what works best for you.”

10 / 10
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Rosinavos July 23, 2014

Plaquenil (hydroxychloroquine): “This medication worked great for me except for some stomach upset which was I tolerating because I wanted to stay off Prednisone. However, three weeks into taking the medication, I developed an allergy to it and broke out in hives all over my body. So I had to discontinue, sadly. Very sorry not to be able to take this medication as it seems the best one for controlling my Lupus with the least side effects.”

7 / 10
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M-Square · Taken for 1 to 2 years March 21, 2020

Plaquenil (hydroxychloroquine): “I've had SLE and a host of other related illnesses for over 30 years. After my fourth (or fifth?) battle with pericarditis, my rheumatologist put me on 200 mg of plaquenil. No real side effects however, I have always been slightly anemic and this seems to have increased quite a bit, mimicking the symptoms of narcolepsy ”

2 / 10
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Angelisback April 9, 2015

“I was diagnosed with lupus and rheumatoid arthritis four years ago. The doctor told me to take hydroxychoroquine and told me to stick to that medicine or my lupus would return. Ever since then I have been doing great. I do have a few side affects but none of that matters to me because I got my childhood back. - Angel Aguillon 14yrs old 04/08/15”

9 / 10
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Barb-Also · Taken for 1 to 6 months January 23, 2016

Plaquenil (hydroxychloroquine): “I had only had a mild SLE flare about 30 years ago. I had plenty of the discoid lupus symptoms, but they were easily controlled with avoiding the sun and using sunscreens,especially in the last 20 years. I developed another auto-immune problem about 15 years ago.(gluten intolerance or or possible CD.) I ate the "gluten-free" Cheerios when they hit the shelves about 6 months ago, and almost killed myself, as they were not gluten free. This touched off a SLE flare of unbelievable proportions! Practically every joint in my body was hurting SO badly,and I had fever and fatigue and did not respond to NSAIDs. Placquenil has been my lifesaver! Adhering to an anti-inflammatory diet for a month helped, also. The price-worth it.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Systemic Lupus Erythematosus

Symptoms and treatments

Mayo Clinic Reference