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Lupus (Systemic Lupus Erythematosus)

Medically reviewed by Last updated on Feb 14, 2022.

What is Lupus (Systemic Lupus Erythematosus)?

Harvard Health Publishing

Lupus is thought to develop when your body's immune system mistakenly attacks the body's own tissues.  Immune proteins called autoantibodies attack many different parts of the body causing inflammation and tissue damage.  This may include the joints, skin, kidney, nervous system (brain, spinal cord and nerves), blood, heart, lungs, digestive system and eyes. Autoantibodies also can attach themselves to body chemicals, forming abnormal molecules called immune complexes that trigger additional inflammation and injury when they are deposited in various organs and tissues.

The exact cause of lupus remains a mystery, although scientists are investigating many different possibilities and believe several factors may play a role in the development of the disease. Since 90% of all lupus patients are women, usually of childbearing age, researchers think hormones may be involved. Lupus tends to run in families, so genetic factors may play a role. In the U.S., lupus is more common among African Americans, African Caribbeans, Asian Americans and Hispanic Americans than Caucasians.  Some researchers think lupus may be triggered by a virus or another type of infection in people who are genetically susceptible to the disease.

Lupus is relatively rare, affecting less than one in 2,000 people. The scientific name of the disease is systemic lupus erythematosus, or SLE.


Your doctor will begin by reviewing your symptoms, your medical history and your exposure to factors that can trigger lupus flares. Next, he or she will examine you, looking for skin rashes on your face or on sun-exposed skin, tenderness or swelling of the joints and ulcers inside your mouth or nose. Your doctor will listen to your heart and lungs with a stethoscope, checking for signs of inflammation of the membrane covering the heart (pericarditis) or inflammation of the membranes covering the lungs (pleuritis).

If your doctor suspects you have lupus, he or she will order a blood test to look for a type of antibody, called the antinuclear antibody (ANA), that almost all people with lupus have in their blood. However, since the ANA test is often positive in people who do not have lupus, your doctor may order follow-up blood tests to look for other types of antibodies. Lupus cannot be diagnosed only on the basis of the ANA test.

Your doctor may evaluate your condition using the criteria established by the American College of Rheumatology. Your doctor may diagnose lupus even if you don't meet all of these criteria, which were developed for research studies. If you have had 4 of the 17 lupus criteria at some time during your illness, even if fewer than four are active at the time of diagnosis, the diagnosis is more certain and you may be eligible for entry into a research study of lupus. 

At least one of the positive criteria must be "clinical" (causing symptoms or affecting a particular part of the body) and one must be a laboratory abnormality (such as an abnormal blood test). The diagnosis can be established without meeting 4 criteria if a kidney biopsy shows evidence of lupus kidney disease along with certain antibodies (including antinuclear antibodies or anti-ds-DNA) present in the blood).The lupus criteria include the following:

  • Certain types of rashes (called acute or chronic cutaneous lupus)
  • Discoid rash
  • Hair loss
  • Ulcers in the mouth or nose
  • Arthritis
  • Pericarditis, confirmed by physical exam or electrocardiogram (EKG), or pleuritis, confirmed by physical findings or chest X-ray
  • Kidney disorder, confirmed by finding high levels of protein in the urine or other specific urine abnormalities, especially red cells suggesting inflammation in the kidney
  • Neurological disorder, including seizures or psychosis (a serious psychiatric illness)
  • Blood disorder, including evidence of red blood cell destruction (hemolytic anemia), low white blood cells (leukopenia) or low platelets (thrombocytopenia)
  • Immune disorder — This is established by the finding of certain antibodies in the blood, which may include a positive anti-ds-DNA test, a positive anti-Smith antibody test, a positive test for syphilis even though you don't have syphilis or a positive antiphospholipid antibody test (an antibody associated with miscarriage or blood clots).
  • A positive ANA test result
  • Low complement levels (proteins involved in inflammation)
  • Antibodies linked with red blood cell destruction, called a positive Coombs’ test

Other tests that may be done to help diagnose lupus include:

  • Erythrocyte sedimentation rate (ESR), a blood test that indicates the presence of inflammation
  • A blood test to check levels of proteins involved in immune function
  • A skin or kidney biopsy (taking a small tissue sample for laboratory examination)
  • Additional blood tests for autoantibodies

Expected Duration

Lupus is a long-lasting (chronic) condition, although there may be periods in which the illness is relatively inactive or even completely quiet.


Since doctors haven't determined the cause of lupus, there's no way to prevent it. You may be able to prevent flare-ups of the illness by avoiding exposure to the sun as much as possible and using sunscreen when you are in the sun.


Lupus may be treated with several different types of medication, including:

  • Nonsteroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen (Advil, Motrin and other brand names) or naproxen (Aleve, Naprosyn and others)
  • Antimalarials, such as hydroxychloroquine (Plaquenil), chloroquine (Aralen), or quinacrine. Recent studies suggest that lupus patients treated with antimalarial medications have less active disease and less organ damage over time. Therefore, many experts now recommend antimalarial treatment for all patients with systemic lupus unless they cannot tolerate the medication.
  • Corticosteroids, such as prednisone (Deltasone and others), hydrocortisone, methylprednisolone (Medrol and others), or dexamethasone (Decadron and others)
  • Immunosuppressives, such as azathioprine (Imuran), methotrexate (Rheumatrex, Folex, Methotrexate LPF), cyclophosphamide (Cytoxan, Neosar), mycophenolate mofetil (CellCept), or belimumab (Benlysta)

Treatment options

The following list of medications are in some way related to or used in the treatment of this condition.

View more treatment options

When To Call a Professional

Call your doctor if you have any of the symptoms of lupus, especially if you develop skin symptoms (malar or discoid rash, photosensitivity, ulcers in your mouth or nose), together with fatigue, fever, joint pain, poor appetite and weight loss.


Most people with lupus have a normal life span. However, life expectancy and quality of life vary widely depending on severity of illness. Cardiovascular disease, including heart attack, is more common among people with lupus. The presence of cardiovascular disease worsens prognosis. The outlook is also worse if the disease has seriously affected the kidneys or brain.

Learn more about Lupus

Treatment options

Care guides

External resources

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Lupus Foundation of America

American College of Rheumatology


Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.