Arynta

Pronunciation: Ah-rin-tah
Generic name: lisdexamfetamine dimesylate
Dosage form: oral solution (10 mg/mL)
Drug class: CNS stimulants

Medically reviewed by Carmen Pope, BPharm. Last updated on Jun 24, 2025.

What is Arynta?

Arynta is used to treat Attention Deficit Hyperactivity Disorder (ADHD) in adults and children 6 years of age and older and Binge Eating Disorder (BED) in adults. It is an oral solution taken once a day in the morning.

The exact way Arynta works for ADHD and BED is not known, but once in the body lisdexamfetamine, the active ingredient of Arynta, is converted to dexamphetamine, which blocks dopamine and norepinephrine reuptake in the brain. This increases neurotransmitter levels in the prefrontal cortex, improving executive function, attention, and impulse control. Arynta belongs to the drug class called central nervous system (CNS) stimulants.

Arynta is a federally controlled substance (CII) because it contains lisdexamfetamine dimesylate that can be a target for people who abuse prescription medicines or street drugs. Keep Arynta in a safe place to protect it from theft. Never give your Arynta to anyone else because it may cause death or harm them. Selling or giving away Arynta may harm others and is against the law.

Arynta gained FDA approval on June 16, 2025. Lisdexamphetamine has been approved since 2007.

FDA approvals and uses

Arynta is approved for:

• Attention Deficit Hyperactivity Disorder (ADHD) in adults and children 6 years of age and older, to help increase attention and decrease impulsiveness and hyperactivity in people with ADHD.
• Moderate to severe binge eating disorder (BED) in adults, to help reduce the number of binge eating days in people with BED.

Arynta is not for use in children under 6 years of age with ADHD.

Arynta is not for weight loss. It is not known if Arynta is safe and effective for the treatment of obesity. It is not known if Arynta is safe and effective for use in children with BED.

Side effects

The most common side effects of Arynta in ADHD are:

• loss of appetite (anorexia)
• decreased appetite
• diarrhea
• dry mouth
• trouble sleeping
• stomach pain
• anxiety
• weight loss
• dizziness
• irritability
• nausea
• vomiting.

The most common side effects of Arynta in BED are:

• dry mouth
• decreased appetite
• constipation
• anxiety
• trouble sleeping
• increased heart rate
• feeling jittery.

Serious side effects and warnings

Arynta carries a Boxed Warning for abuse, misuse, and addiction.

Abuse, misuse, and addiction.

Arynta has a high chance for abuse and misuse, which may lead to substance use problems, including addiction. Misuse and abuse of Arynta, other amphetamine containing medicines, and methylphenidate containing medicines, can lead to overdose and death. The risk of overdose and death is increased with higher doses of Arynta or when it is used in ways that are not approved, such as snorting or injection.

Your healthcare provider should check you or your child's risk for abuse, misuse, and addiction before starting treatment with Arynta and will monitor you or your child during treatment.

Arynta may lead to physical dependence after prolonged use, even if taken as directed by your healthcare provider.

• Do not give Arynta to anyone else.
• Keep Arynta in a safe place and properly dispose of any unused medicine.
• Tell your healthcare provider if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Arynta may cause the following other serious side effects:

• Risks for people with serious heart disease. Sudden death has happened in people who have heart defects or other serious heart disease. Your healthcare provider should check you or your child carefully for heart problems before starting treatment with Arynta. Tell your healthcare provider if you or your child have any heart problems, heart disease, or heart defects.

Call your healthcare provider right away or go to the nearest hospital emergency room right away if you or your child have any signs of heart problems such as chest pain, shortness of breath, or fainting during treatment with Arynta.

• Increased blood pressure and heart rate. Your healthcare provider should check you or your child's blood pressure and heart rate regularly during treatment with Arynta.
• Mental (psychiatric) problems, including:
  • new or worse behavior and thought problems
  • new or worse bipolar illness
  • new psychotic symptoms (such as hearing voices, or seeing or believing things that are not real) or new manic symptoms.

Tell your healthcare provider about any mental problems you or your child have or about a family history of suicide, bipolar illness, or depression.

Call your healthcare provider right away if you or your child have any new or worsening mental symptoms or problems during treatment with Arynta, especially hearing voices, seeing or believing things that are not real, or new manic symptoms.

• Slowing of growth (height and weight) in children. Children should have their height and weight checked often during treatment with Arynta. Arynta treatment may be stopped if your child is not growing or gaining weight as expected
• Circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud's phenomenon). Signs and symptoms may include:
  • fingers or toes may feel numb, cool, or painful
  • fingers or toes may change color from pale, to blue, to red.

Tell your healthcare provider if you or your child have numbness, pain, skin color change, or sensitivity to temperature in your fingers or toes.

Call your healthcare provider right away if you or your child have any signs of unexplained wounds appearing on fingers or toes during treatment with Arynta.

• Serotonin syndrome. A potentially life-threatening problem called serotonin syndrome may happen when Arynta is taken with certain other medicines. Stop taking Arynta and call your healthcare provider or go to the nearest hospital emergency room right away if you or your child develop any of the following signs and symptoms of serotonin syndrome:
  • agitation
  • fast heartbeat
  • flushing
  • seizures
  • coma
  • sweating
  • loss of coordination
  • confusion
  • dizziness
  • tremors, stiff muscles, or muscle twitching
  • seeing or hearing things that are not real (hallucinations)
  • changes in blood pressure
  • nausea, vomiting, diarrhea
  • high body temperature (hyperthermia).
• New or worsening tics or worsening Tourette's syndrome. Tell your healthcare provider if you or your child get any new or worsening tics or worsening Tourette's syndrome during treatment with Arynta.

These are not all the possible side effects of Arynta. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Before taking

Do not take Arynta if you or your child are:

• allergic to amphetamine products or any of the ingredients in Arynta (see below)
• taking, or have stopped taking in the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI)
• being treated with the antibiotic linezolid or intravenous methylene blue.

Before taking Arynta, tell your healthcare provider about all medical conditions, including if you or your child:

• have heart problems, heart disease, heart defects, or high blood pressure, or have a family history of sudden death or heart rhythm problems
• have mental problems including psychosis, mania, bipolar illness, or depression or have a family history of suicide, bipolar illness, or depression
• have circulation problems in fingers and toes
• have kidney problems
• have or had repeated movements or sounds (tics) or Tourette's syndrome, or have a family history of tics or Tourette's syndrome
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed.

Pregnancy

Arynta may harm the unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with Arynta.

There is a pregnancy registry for women who are exposed to Arynta during pregnancy. If you become pregnant during treatment with Arynta, talk to your healthcare provider about registering with the National Pregnancy Registry for Psychostimulants at 1-866-961-2388 or visiting online at https://womensmentalhealth.org/clinical-and researchprograms/pregnancyregistry/adhdmedications/

Breastfeeding

Arynta passes into breast milk. You should not breastfeed during treatment with Arynta. Talk to your healthcare provider about the best way to feed the baby during treatment with Arynta.

How do I take Arynta?

Read the Instructions for Use for detailed instructions about how to measure and take a dose of Arynta. Take Arynta exactly as prescribed by your or your child’s healthcare provider. Your healthcare provider may change the dose if needed.

• Arynta is an oral solution that is taken 1 time a day.
• Take Arynta in the morning with or without food. Taking it in the afternoon may cause trouble sleeping.

What happens if I take too much?

If you or your child takes too much Arynta, call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Dosing information

Before treatment, assess for the presence of cardiac disease.

• In severe renal impairment, the maximum dose is 50 mg/day
• In end-stage renal disease (ESRD), the maximum dose is 30 mg/day.

Dose of Arynta for ADHD (Adults and children 6 years and older)

• Initial dose: 30 mg every morning
• Titration: 10 mg or 20 mg weekly
• Recommended dose: 30 mg to 70 mg per day
• Maximum dose: 70 mg per day

Dose of Arynta for BED (Adults)

• Initial dose: 30 mg every morning
• Titration: 20 mg weekly
• Recommended dose: 50 mg to 70 mg per day
• Maximum dose: 70 mg per day.

What other medicines will affect Arynta?

Tell your healthcare provider about all the medicines that you or your child takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Arynta can affect the way other medicines work, and other medicines may affect how Arynta works. Taking Arynta with other medicines can cause serious side effects. Sometimes the doses of other medicines will need to be changed during treatment with Arynta.

Especially tell your healthcare provider if you or your child takes:

• selective serotonin reuptake inhibitors (SSRIs)
• serotonin norepinephrine reuptake inhibitors (SNRIs)
• medicines used to treat migraine headaches, called triptans
• tricyclic antidepressants
• lithium
• fentanyl
• tramadol
• tryptophan
• buspirone
• St. John's Wort.

Keep a list of all medicines to show your healthcare provider and pharmacist when you get a new medicine. Your healthcare provider will decide if Arynta can be taken with other medicines.

Do not start any new medicine during treatment with Arynta without talking to your healthcare provider first.

Storage

Store Arynta at room temperature between 68°F to 77°F (20°C to 25°C). Keep the container tightly closed.

• Store in a safe place (like a locked cabinet).
• Throw away (discard) any remaining Arynta 30 days after first opening the bottle.

Dispose of remaining, unused, or expired Arynta by a medicine take-back program at a U.S. Drug Enforcement Administration (DEA) authorized collection site.

• If no take-back program or DEA authorized collector is available, mix Arynta with an undesirable, nontoxic substance such as dirt, cat litter, or used coffee grounds to make it less appealing to children and pets.
• Place the solution in a container such as a sealed plastic bag and throw away Arynta in the household trash.
• Visit www.fda.gov/drugdisposal for additional information on the disposal of unused medicines.

Keep out of the reach of children.

What are the ingredients in Arynta?

Active ingredient: lisdexamfetamine dimesylate

Inactive ingredients: dibasic sodium phosphate dihydrate, methylparaben sodium, monobasic sodium phosphate dihydrate, propylparaben sodium, propylene glycol, saccharin sodium, hydrochloric acid, sodium hydroxide and purified water.

Manufacturer

Arynta is manufactured by Azurity Pharmaceuticals, Inc., Woburn, MA 01801.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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