Comparing Accutane vs Methotrexate
| Accutane (isotretinoin) | Methotrexate |
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| Accutane (isotretinoin) | Methotrexate |
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Prescription only
Prescribed for Rosacea, Acne, Acute Nonlymphocytic Leukemia, Granuloma Annulare. Accutane may also be used for purposes not listed in this medication guide. |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Acute Nonlymphocytic Leukemia
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| More about Accutane (isotretinoin) | More about Methotrexate | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Accutane has an average rating of 7.9 out of 10 from a total of 657 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 14% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 335 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Accutane side effects |
View all Methotrexate side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Lower cost generic approved |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Accutane prices |
View all Methotrexate prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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32 hours |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 140 drugs are known to interact with Accutane:
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A total of 722 drugs are known to interact with Methotrexate:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 07, 1982 |
December 07, 1953 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.