Comparing Accutane vs Differin
Accutane (isotretinoin) | Differin (adapalene) |
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Accutane (isotretinoin) | Differin (adapalene) |
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Prescription only
Prescribed for Rosacea, Acne, Granuloma Annulare, Acute Nonlymphocytic Leukemia. Accutane may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Prescribed for Acne. Differin may also be used for purposes not listed in this medication guide. |
Related suggestions |
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More about Accutane (isotretinoin) | More about Differin (adapalene) | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Accutane has an average rating of 7.9 out of 10 from a total of 657 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 14% reported a negative effect. |
Differin has an average rating of 6.1 out of 10 from a total of 345 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 36% reported a negative effect. |
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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Accutane side effects |
View all Differin side effects |
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Drug Class | |||||||||||||||||
Generic Availability | |||||||||||||||||
Lower cost generic approved | |||||||||||||||||
Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Accutane prices |
View all Differin prices |
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Dosage Forms | |||||||||||||||||
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Brand Names | |||||||||||||||||
Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Other adapalene brands include: Plixda | ||||||||||||||||
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
32 hours |
51 hours |
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CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 142 drugs are known to interact with Accutane:
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A total of 12 drugs are known to interact with Differin:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
May 07, 1982 |
May 31, 1996 |
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WADA Class View classifications | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient Resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.