Comparing Accutane vs Differin
| Accutane (isotretinoin) | Differin (adapalene) |
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| Accutane (isotretinoin) | Differin (adapalene) |
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Prescription only
Prescribed for Rosacea, Acne, Acute Nonlymphocytic Leukemia, Granuloma Annulare. Accutane may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Prescribed for Acne. Differin may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Accutane (isotretinoin) | More about Differin (adapalene) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Accutane has an average rating of 7.9 out of 10 from a total of 657 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 14% reported a negative effect. |
Differin has an average rating of 6.1 out of 10 from a total of 344 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 36% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Accutane side effects |
View all Differin side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Lower cost generic approved | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Accutane prices |
View all Differin prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Other adapalene brands include: Plixda | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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32 hours |
51 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 140 drugs are known to interact with Accutane:
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A total of 12 drugs are known to interact with Differin:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 07, 1982 |
May 31, 1996 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.