Comparing Accutane vs Differin
| Accutane (isotretinoin) | Differin (adapalene) |
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| Accutane (isotretinoin) | Differin (adapalene) |
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Prescription only
Prescribed for Acne, Rosacea, Acute Nonlymphocytic Leukemia, Granuloma Annulare. Accutane may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Prescribed for Acne. Differin may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Accutane (isotretinoin) | More about Differin (adapalene) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Accutane has an average rating of 7.9 out of 10 from a total of 657 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 14% reported a negative effect. |
Differin has an average rating of 6.1 out of 10 from a total of 346 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 36% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Accutane side effects |
View all Differin side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Lower cost generic approved | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Accutane prices |
View all Differin prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Other adapalene brands include: Plixda | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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32 hours |
51 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 142 drugs are known to interact with Accutane:
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A total of 12 drugs are known to interact with Differin:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 07, 1982 |
May 31, 1996 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.