Drug interactions between leucovorin and methotrexate
Interactions between your drugs
Applies to: methotrexate and leucovorin
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site.
MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.
- "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Drug and food interactions
Applies to: methotrexate
Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and medications. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.