Leucovorin Drug Interactions
A total of 25 drugs (113 brand and generic names) are known to interact with leucovorin.
- 6 major drug interactions (31 brand and generic names)
- 19 moderate drug interactions (82 brand and generic names)
Check for interactions with leucovorin
Common medications checked in combination with leucovorin
- Ativan (lorazepam)
- Avastin (bevacizumab)
- Benadryl (diphenhydramine)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Humira (adalimumab)
- Methotrexate LPF Sodium (methotrexate)
- MiraLax (polyethylene glycol 3350)
- Nexium (esomeprazole)
- OxyContin (oxycodone)
- Plaquenil (hydroxychloroquine)
- Protonix (pantoprazole)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Zofran (ondansetron)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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