Leucovorin (folinic acid; 5-formyltetrahydrofolic acid) and its levo- isomer, levoleucovorin, are folic acid derivatives that are normal components of breastmilk.[1,2] Because leucovorin and levoleucovorin are used as therapeutic agents with potentially toxic drugs such as fluorouracil or methotrexate, the LactMed record of the drug it is used with should be consulted.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
1.
Page R, Robichaud A, Arbuckle TE, et al. Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women. Am J Clin Nutr 2017;105:1101-9. [PubMed: 28298392]
2.
Su Y, Mao Y, Tian F, et al. Profile of folate in breast milk from Chinese women over 1-400 days postpartum. Nutrients 2022;14:2962. [PMC free article: PMC9319857] [PubMed: 35889919]
Substance Identification
Substance Name
Leucovorin
CAS Registry Number
58-05-9
Drug Class
Breast Feeding
Lactation
Milk, Human
Antidotes
Vitamin B Complex
Vitamins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
