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Leucovorin Disease Interactions

There are 4 disease interactions with leucovorin:


Leucovorin (applies to leucovorin) anemia

Major Potential Hazard, High plausibility. Applicable conditions: Anemia of Unspecified Nutritional Deficiency

The use of leucovorin is inappropriate therapy for patients with undiagnosed anemia. Leucovorin can obscure the diagnosis of pernicious anemia by alleviating the hematologic conditions and allowing progression of neurologic complications.


  1. "Product Information. Wellcovorin (leucovorin)." Glaxo Wellcome, Research Triangle Park, NC.

Leucovorin (applies to leucovorin) GI toxicity

Major Potential Hazard, Moderate plausibility. Applicable conditions: Diarrhea, Vomiting

Leucovorin enhances the toxicity of 5-fluorouracil. When these drugs are administered concurrently in the palliative therapy of advanced colorectal cancer, gastrointestinal toxicities, particularly stomatitis and diarrhea are observed more commonly and may be more severe and of prolonged duration. Therapy with these agents must not be initiated or continued in patients who have symptoms of gastrointestinal toxicity of any severity until those symptoms have completely resolved. Monitor patients experiencing diarrhea and institute appropriate care.


Leucovorin (applies to leucovorin) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Leucovorin is excreted by the kidney and the risk of toxic reactions to the drug may be greater in patients with impaired renal function. Leucovorin should be used cautiously on these patients, and care should be taken in dose selection. Monitoring of renal function is recommended.


Leucovorin (applies to leucovorin) seizures

Moderate Potential Hazard, Low plausibility.

Seizures have occurred rarely during administration of leucovorin, primarily in patients receiving high dose leucovorin or leucovorin in combination with 5-fluorouracil, or in patients with a history of seizures or central nervous system abnormalities (unspecified). Folic acid in large amounts may counter the anticonvulsant effects of phenobarbital, phenytoin, and pimozide. Clinical monitoring of seizure activity is recommended and modification of anticonvulsant therapy may be necessary.


  1. "Product Information. Wellcovorin (leucovorin)." Glaxo Wellcome, Research Triangle Park, NC.

Leucovorin drug interactions

There are 27 drug interactions with leucovorin

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.